Incidental Mutation 'R0891:Or6z6'
ID 83503
Institutional Source Beutler Lab
Gene Symbol Or6z6
Ensembl Gene ENSMUSG00000034583
Gene Name olfactory receptor family 6 subfamily Z member 6
Synonyms Olfr1347, GA_x6K02T2QGBW-3218686-3217748, MOR103-11, MOR103-19_i
MMRRC Submission 039054-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.131) question?
Stock # R0891 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 6490912-6491871 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 6491471 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 134 (Y134F)
Ref Sequence ENSEMBL: ENSMUSP00000152024 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036357] [ENSMUST00000086318] [ENSMUST00000207339] [ENSMUST00000209055] [ENSMUST00000209866] [ENSMUST00000220413]
AlphaFold Q8VF33
Predicted Effect probably damaging
Transcript: ENSMUST00000036357
AA Change: Y127F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000046590
Gene: ENSMUSG00000034583
AA Change: Y127F

DomainStartEndE-ValueType
Pfam:7tm_4 42 318 2.5e-50 PFAM
Pfam:7tm_1 52 301 2.3e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000086318
SMART Domains Protein: ENSMUSP00000083498
Gene: ENSMUSG00000096228

DomainStartEndE-ValueType
Pfam:7tm_4 35 311 2.1e-50 PFAM
Pfam:7tm_1 45 294 6.9e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000207339
AA Change: Y127F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably benign
Transcript: ENSMUST00000209055
Predicted Effect probably benign
Transcript: ENSMUST00000209866
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218572
Predicted Effect probably damaging
Transcript: ENSMUST00000220413
AA Change: Y134F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.2316 question?
Coding Region Coverage
  • 1x: 99.7%
  • 3x: 98.9%
  • 10x: 96.7%
  • 20x: 92.2%
Validation Efficiency 100% (41/41)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930522L14Rik A T 5: 109,884,156 (GRCm39) N567K possibly damaging Het
Afap1 G A 5: 36,119,196 (GRCm39) probably null Het
Angel2 G T 1: 190,677,270 (GRCm39) K517N possibly damaging Het
Ankrd36 A G 11: 5,637,316 (GRCm39) E1295G possibly damaging Het
Ankrd45 A G 1: 160,982,906 (GRCm39) N139S possibly damaging Het
Ano3 T C 2: 110,528,321 (GRCm39) T498A probably benign Het
Arhgap12 T C 18: 6,026,699 (GRCm39) T720A probably damaging Het
Brd10 G A 19: 29,695,053 (GRCm39) T1547I probably damaging Het
Brsk1 A G 7: 4,707,226 (GRCm39) S260G possibly damaging Het
Calml3 A G 13: 3,853,926 (GRCm39) F93S probably damaging Het
Ccnf G T 17: 24,445,751 (GRCm39) H498Q possibly damaging Het
Col27a1 A C 4: 63,223,420 (GRCm39) probably null Het
Cpne5 A G 17: 29,421,893 (GRCm39) probably benign Het
Dcst1 G A 3: 89,260,584 (GRCm39) T560I probably benign Het
Fndc7 A G 3: 108,777,904 (GRCm39) Y351H possibly damaging Het
Gen1 A G 12: 11,298,355 (GRCm39) probably benign Het
Kcnh8 A T 17: 53,212,242 (GRCm39) D680V probably damaging Het
Kmt2d A G 15: 98,750,572 (GRCm39) probably benign Het
Lrrfip1 T A 1: 90,996,337 (GRCm39) I50N probably damaging Het
Mbip A T 12: 56,387,242 (GRCm39) D132E possibly damaging Het
Nipal3 A T 4: 135,195,898 (GRCm39) I235N possibly damaging Het
Nup93 T A 8: 95,007,891 (GRCm39) probably benign Het
Or6b13 A G 7: 139,782,372 (GRCm39) Y104H probably damaging Het
Pgbd1 T C 13: 21,606,970 (GRCm39) Y408C probably damaging Het
Pigo G A 4: 43,020,519 (GRCm39) Q808* probably null Het
Pik3r1 A T 13: 101,837,974 (GRCm39) N299K probably benign Het
Pip5k1a A G 3: 94,972,831 (GRCm39) probably benign Het
Semp2l1 T A 1: 32,585,442 (GRCm39) H156L possibly damaging Het
Septin5 G C 16: 18,443,595 (GRCm39) T118R probably damaging Het
Smarcal1 T C 1: 72,638,015 (GRCm39) V483A probably damaging Het
Togaram1 A G 12: 65,029,421 (GRCm39) D948G probably benign Het
Vmn2r75 A T 7: 85,813,476 (GRCm39) V442E possibly damaging Het
Zfp57 A G 17: 37,317,068 (GRCm39) K46E probably damaging Het
Other mutations in Or6z6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02395:Or6z6 APN 7 6,491,802 (GRCm39) missense possibly damaging 0.83
R0277:Or6z6 UTSW 7 6,491,433 (GRCm39) missense probably benign 0.00
R1394:Or6z6 UTSW 7 6,491,361 (GRCm39) missense probably damaging 1.00
R1395:Or6z6 UTSW 7 6,491,361 (GRCm39) missense probably damaging 1.00
R1503:Or6z6 UTSW 7 6,491,178 (GRCm39) missense probably damaging 1.00
R3014:Or6z6 UTSW 7 6,491,470 (GRCm39) nonsense probably null
R5194:Or6z6 UTSW 7 6,491,519 (GRCm39) missense probably damaging 1.00
R5477:Or6z6 UTSW 7 6,491,570 (GRCm39) missense probably benign 0.00
R6137:Or6z6 UTSW 7 6,491,844 (GRCm39) missense probably benign 0.02
R6212:Or6z6 UTSW 7 6,491,367 (GRCm39) splice site probably null
R6706:Or6z6 UTSW 7 6,491,049 (GRCm39) missense probably damaging 1.00
R7444:Or6z6 UTSW 7 6,490,919 (GRCm39) missense probably benign 0.00
Z1176:Or6z6 UTSW 7 6,491,697 (GRCm39) missense probably damaging 0.98
Z1176:Or6z6 UTSW 7 6,491,691 (GRCm39) missense probably benign 0.00
Z1177:Or6z6 UTSW 7 6,491,203 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- GGACACCAAGAGTGTTCCACAGAAG -3'
(R):5'- GAGATGTGCTATGTGTCAGCCACC -3'

Sequencing Primer
(F):5'- CTGAGATGAAGTCTACCAGCTCTG -3'
(R):5'- ATGTGTCAGCCACCATGCC -3'
Posted On 2013-11-08