|Institutional Source||Beutler Lab|
|Gene Name||phospholipase C, beta 2|
|Essential gene?||Non essential (E-score: 0.000)|
|Stock #||R0893 (G1)|
|Chromosomal Location||118707517-118728438 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||A to G at 118725105 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000124364 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000102524] [ENSMUST00000159756]|
|Coding Region Coverage||
|Validation Efficiency||99% (77/78)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses. [provided by RefSeq, Jan 2017]
PHENOTYPE: Homozygous mutant mice showed an increased sensitivity to both bacterial and viral infections and exhibited abnormal taste perception in which sweet, umami, and bitter stimuli could not be sensed. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Plcb2||
(F):5'- TCCTATACCACCAGGGTTCTAGCG -3'
(R):5'- TCGGGGCACACTTTCCAAGATG -3'
(F):5'- TCATTGGATCCCTTGGAGCT -3'
(R):5'- CTTTCCAAGATGGCAGCAAG -3'