Incidental Mutation 'R0894:Abcc1'
| ID |
83713 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Abcc1
|
| Ensembl Gene |
ENSMUSG00000023088 |
| Gene Name |
ATP-binding cassette, sub-family C member 1 |
| Synonyms |
Mdrap, Mrp1, MRP, Abcc1b, Abcc1a |
| MMRRC Submission |
039057-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.164)
|
| Stock # |
R0894 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
16 |
| Chromosomal Location |
14179317-14292743 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 14283001 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 1159
(V1159A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000097743
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000100167]
[ENSMUST00000130671]
[ENSMUST00000133454]
[ENSMUST00000147759]
|
| AlphaFold |
O35379 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000100167
AA Change: V1159A
PolyPhen 2
Score 0.638 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000097743
Gene: ENSMUSG00000023088
AA Change: V1159A
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
38 |
57 |
N/A |
INTRINSIC |
|
transmembrane domain
|
77 |
94 |
N/A |
INTRINSIC |
|
transmembrane domain
|
104 |
126 |
N/A |
INTRINSIC |
|
transmembrane domain
|
139 |
161 |
N/A |
INTRINSIC |
|
transmembrane domain
|
176 |
198 |
N/A |
INTRINSIC |
|
low complexity region
|
279 |
290 |
N/A |
INTRINSIC |
|
Pfam:ABC_membrane
|
326 |
597 |
7.8e-44 |
PFAM |
|
AAA
|
670 |
845 |
4.07e-8 |
SMART |
|
Pfam:ABC_membrane
|
971 |
1243 |
3e-52 |
PFAM |
|
AAA
|
1316 |
1501 |
5.8e-13 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000130671
|
| SMART Domains |
Protein: ENSMUSP00000116714
Gene: ENSMUSG00000023088
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
38 |
57 |
N/A |
INTRINSIC |
|
transmembrane domain
|
77 |
94 |
N/A |
INTRINSIC |
|
transmembrane domain
|
104 |
126 |
N/A |
INTRINSIC |
|
transmembrane domain
|
139 |
161 |
N/A |
INTRINSIC |
|
transmembrane domain
|
176 |
198 |
N/A |
INTRINSIC |
|
low complexity region
|
279 |
290 |
N/A |
INTRINSIC |
|
Pfam:ABC_membrane
|
326 |
597 |
1.6e-48 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000133454
|
| SMART Domains |
Protein: ENSMUSP00000122656
Gene: ENSMUSG00000023088
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
38 |
57 |
N/A |
INTRINSIC |
|
transmembrane domain
|
77 |
94 |
N/A |
INTRINSIC |
|
transmembrane domain
|
104 |
126 |
N/A |
INTRINSIC |
|
transmembrane domain
|
139 |
161 |
N/A |
INTRINSIC |
|
transmembrane domain
|
176 |
198 |
N/A |
INTRINSIC |
|
low complexity region
|
279 |
290 |
N/A |
INTRINSIC |
|
Pfam:ABC_membrane
|
326 |
597 |
1.6e-48 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000134960
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000146032
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000147759
|
| SMART Domains |
Protein: ENSMUSP00000115627
Gene: ENSMUSG00000023088
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
38 |
57 |
N/A |
INTRINSIC |
|
transmembrane domain
|
77 |
94 |
N/A |
INTRINSIC |
|
transmembrane domain
|
104 |
126 |
N/A |
INTRINSIC |
|
transmembrane domain
|
139 |
161 |
N/A |
INTRINSIC |
|
transmembrane domain
|
176 |
198 |
N/A |
INTRINSIC |
|
low complexity region
|
279 |
290 |
N/A |
INTRINSIC |
|
Pfam:ABC_membrane
|
326 |
597 |
1.6e-48 |
PFAM |
|
| Meta Mutation Damage Score |
0.1983 |
| Coding Region Coverage |
- 1x: 99.5%
- 3x: 99.0%
- 10x: 97.7%
- 20x: 95.8%
|
| Validation Efficiency |
97% (102/105) |
| MGI Phenotype |
FUNCTION: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein plays an essential role in the defense against toxic compounds and serves as the major high-affinity transporter of leukotriene C4. The encoded protein may also play an essential role in steroid hormone homeostasis as a transporter for steroid hormones and their metabolites. [provided by RefSeq, Nov 2011]
PHENOTYPE: Mice homozygous for targeted mutations that inactivate the gene have a reduced response to inflammatory stimulus, increased levels of glutathione due to impaired metabolism, and are hypersensitive to the anticancer drug etoposide. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 104 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2210408I21Rik |
A |
G |
13: 77,471,726 (GRCm39) |
S1044G |
probably benign |
Het |
| Aanat |
A |
G |
11: 116,487,730 (GRCm39) |
H143R |
probably benign |
Het |
| Abca8a |
A |
G |
11: 109,941,792 (GRCm39) |
I1159T |
probably benign |
Het |
| Abcb1a |
G |
T |
5: 8,724,856 (GRCm39) |
|
probably benign |
Het |
| Akr1e1 |
T |
A |
13: 4,645,071 (GRCm39) |
Q204L |
probably damaging |
Het |
| Alk |
T |
C |
17: 72,202,930 (GRCm39) |
Y1135C |
probably damaging |
Het |
| Atad2b |
C |
T |
12: 5,015,915 (GRCm39) |
T547I |
probably damaging |
Het |
| Brd10 |
T |
C |
19: 29,697,974 (GRCm39) |
|
probably benign |
Het |
| C030005K15Rik |
A |
T |
10: 97,561,648 (GRCm39) |
S28T |
unknown |
Het |
| Cdk5rap3 |
A |
G |
11: 96,799,654 (GRCm39) |
L387P |
probably damaging |
Het |
| Cfap95 |
T |
C |
19: 23,630,062 (GRCm39) |
E10G |
unknown |
Het |
| Cfap96 |
A |
G |
8: 46,409,497 (GRCm39) |
F274S |
probably damaging |
Het |
| Clec4f |
T |
A |
6: 83,629,979 (GRCm39) |
N193I |
probably damaging |
Het |
| Col4a4 |
A |
T |
1: 82,507,377 (GRCm39) |
|
probably null |
Het |
| Cplx4 |
T |
G |
18: 66,090,116 (GRCm39) |
D101A |
possibly damaging |
Het |
| Cpne8 |
A |
T |
15: 90,533,474 (GRCm39) |
D50E |
probably damaging |
Het |
| Csmd3 |
G |
T |
15: 47,721,316 (GRCm39) |
D1542E |
possibly damaging |
Het |
| Ctdp1 |
A |
G |
18: 80,512,736 (GRCm39) |
V9A |
probably benign |
Het |
| Ctnnd2 |
A |
T |
15: 30,332,301 (GRCm39) |
|
probably benign |
Het |
| Cyp7b1 |
C |
T |
3: 18,151,674 (GRCm39) |
A180T |
probably benign |
Het |
| Dcun1d5 |
C |
T |
9: 7,203,379 (GRCm39) |
|
probably benign |
Het |
| Dgat1 |
G |
T |
15: 76,387,199 (GRCm39) |
L363I |
possibly damaging |
Het |
| Dipk2b |
T |
A |
X: 18,289,791 (GRCm39) |
I224F |
possibly damaging |
Het |
| Dlg1 |
T |
A |
16: 31,561,965 (GRCm39) |
H120Q |
probably benign |
Het |
| Dnah6 |
T |
C |
6: 73,101,740 (GRCm39) |
N1928S |
probably benign |
Het |
| Dnai4 |
T |
C |
4: 102,906,583 (GRCm39) |
|
probably benign |
Het |
| Dync2h1 |
A |
T |
9: 7,041,734 (GRCm39) |
|
probably benign |
Het |
| Ednra |
T |
G |
8: 78,446,649 (GRCm39) |
|
probably benign |
Het |
| Efcab6 |
A |
T |
15: 83,802,493 (GRCm39) |
C845S |
probably benign |
Het |
| Egln1 |
A |
T |
8: 125,642,435 (GRCm39) |
C303S |
probably damaging |
Het |
| Eomes |
T |
C |
9: 118,311,368 (GRCm39) |
|
probably null |
Het |
| Epha1 |
A |
G |
6: 42,340,756 (GRCm39) |
V568A |
probably benign |
Het |
| Ercc6 |
T |
A |
14: 32,238,985 (GRCm39) |
N24K |
probably benign |
Het |
| Esco2 |
T |
C |
14: 66,064,726 (GRCm39) |
Q338R |
probably benign |
Het |
| Fbxo46 |
T |
C |
7: 18,869,654 (GRCm39) |
V91A |
probably damaging |
Het |
| Fryl |
A |
T |
5: 73,198,675 (GRCm39) |
|
probably benign |
Het |
| Gab3 |
A |
C |
X: 74,077,024 (GRCm39) |
D43E |
probably damaging |
Het |
| Gltpd2 |
T |
A |
11: 70,410,535 (GRCm39) |
|
probably benign |
Het |
| Gm17333 |
G |
T |
16: 77,649,711 (GRCm39) |
|
noncoding transcript |
Het |
| Gm7353 |
T |
C |
7: 3,160,570 (GRCm39) |
|
noncoding transcript |
Het |
| Grik4 |
T |
C |
9: 42,599,405 (GRCm39) |
|
probably benign |
Het |
| Gtpbp2 |
G |
T |
17: 46,476,895 (GRCm39) |
A358S |
possibly damaging |
Het |
| Hyls1 |
C |
T |
9: 35,472,528 (GRCm39) |
C296Y |
probably damaging |
Het |
| Igf2r |
C |
T |
17: 12,910,988 (GRCm39) |
M1943I |
probably benign |
Het |
| Iqca1l |
T |
C |
5: 24,755,731 (GRCm39) |
|
probably null |
Het |
| Ireb2 |
T |
A |
9: 54,803,861 (GRCm39) |
N517K |
probably damaging |
Het |
| Itga10 |
A |
G |
3: 96,560,976 (GRCm39) |
S614G |
possibly damaging |
Het |
| Kdm2b |
A |
G |
5: 123,122,523 (GRCm39) |
|
probably null |
Het |
| Kif17 |
T |
C |
4: 138,025,542 (GRCm39) |
M948T |
possibly damaging |
Het |
| Klhl33 |
A |
T |
14: 51,129,583 (GRCm39) |
N347K |
probably damaging |
Het |
| Llph |
T |
A |
10: 120,064,086 (GRCm39) |
C67* |
probably null |
Het |
| Lrrn3 |
T |
C |
12: 41,504,033 (GRCm39) |
T95A |
probably damaging |
Het |
| Map3k12 |
C |
A |
15: 102,410,613 (GRCm39) |
A455S |
probably damaging |
Het |
| Mex3d |
T |
C |
10: 80,217,376 (GRCm39) |
T149A |
probably benign |
Het |
| Myo7b |
A |
G |
18: 32,133,123 (GRCm39) |
W409R |
probably damaging |
Het |
| Nbea |
A |
G |
3: 55,916,761 (GRCm39) |
M833T |
possibly damaging |
Het |
| Ncapg |
A |
G |
5: 45,837,236 (GRCm39) |
T436A |
probably null |
Het |
| Nkx1-2 |
C |
A |
7: 132,201,042 (GRCm39) |
D72Y |
probably null |
Het |
| Or11g27 |
T |
C |
14: 50,771,159 (GRCm39) |
S97P |
possibly damaging |
Het |
| Or2d3b |
T |
A |
7: 106,514,317 (GRCm39) |
I304K |
probably benign |
Het |
| Or6c217 |
T |
A |
10: 129,737,751 (GRCm39) |
N276I |
probably damaging |
Het |
| Pcdh15 |
A |
G |
10: 74,460,087 (GRCm39) |
Y1308C |
probably damaging |
Het |
| Pcnx2 |
A |
G |
8: 126,613,665 (GRCm39) |
|
probably benign |
Het |
| Pcsk1 |
G |
A |
13: 75,246,096 (GRCm39) |
G158D |
probably damaging |
Het |
| Phkb |
A |
T |
8: 86,744,070 (GRCm39) |
D573V |
probably damaging |
Het |
| Pik3r4 |
A |
G |
9: 105,544,970 (GRCm39) |
K150E |
possibly damaging |
Het |
| Ppp2r5e |
C |
G |
12: 75,516,341 (GRCm39) |
A239P |
probably damaging |
Het |
| Ppp4r4 |
C |
T |
12: 103,566,754 (GRCm39) |
A67V |
probably damaging |
Het |
| Prex2 |
A |
G |
1: 11,252,122 (GRCm39) |
T1056A |
probably benign |
Het |
| Prkca |
A |
T |
11: 107,903,518 (GRCm39) |
Y285N |
possibly damaging |
Het |
| Psd |
T |
C |
19: 46,301,880 (GRCm39) |
E903G |
probably damaging |
Het |
| Psg19 |
T |
C |
7: 18,527,987 (GRCm39) |
E252G |
probably benign |
Het |
| Psg20 |
T |
A |
7: 18,414,969 (GRCm39) |
K306* |
probably null |
Het |
| Pygl |
T |
G |
12: 70,241,148 (GRCm39) |
|
probably benign |
Het |
| Rasgrf2 |
A |
G |
13: 92,130,890 (GRCm39) |
S724P |
probably damaging |
Het |
| Reck |
C |
A |
4: 43,922,967 (GRCm39) |
A414D |
probably damaging |
Het |
| Scn10a |
C |
A |
9: 119,459,213 (GRCm39) |
V1150L |
probably damaging |
Het |
| Shc2 |
A |
T |
10: 79,465,751 (GRCm39) |
I187N |
probably damaging |
Het |
| Sipa1l3 |
T |
A |
7: 29,086,716 (GRCm39) |
K625* |
probably null |
Het |
| Slc44a4 |
T |
C |
17: 35,147,466 (GRCm39) |
L583P |
possibly damaging |
Het |
| Slc5a11 |
G |
C |
7: 122,857,643 (GRCm39) |
R244P |
possibly damaging |
Het |
| Slfn8 |
T |
A |
11: 82,894,407 (GRCm39) |
Q744L |
probably benign |
Het |
| Snx2 |
G |
T |
18: 53,309,488 (GRCm39) |
V13L |
probably benign |
Het |
| Spmip5 |
A |
T |
19: 58,776,015 (GRCm39) |
L138Q |
probably damaging |
Het |
| Spsb1 |
C |
T |
4: 149,990,872 (GRCm39) |
|
probably null |
Het |
| Stfa2l1 |
A |
T |
16: 35,977,228 (GRCm39) |
I8L |
probably benign |
Het |
| Svil |
G |
T |
18: 5,097,494 (GRCm39) |
R1659L |
probably damaging |
Het |
| Tbccd1 |
A |
T |
16: 22,640,995 (GRCm39) |
L461M |
probably benign |
Het |
| Tmem9 |
A |
T |
1: 135,961,926 (GRCm39) |
T174S |
possibly damaging |
Het |
| Tnks2 |
T |
C |
19: 36,867,450 (GRCm39) |
|
probably null |
Het |
| Tnrc18 |
C |
A |
5: 142,800,869 (GRCm39) |
V30L |
probably benign |
Het |
| Tomm7 |
A |
G |
5: 24,049,025 (GRCm39) |
F16S |
probably damaging |
Het |
| Ttf2 |
A |
G |
3: 100,876,865 (GRCm39) |
|
probably benign |
Het |
| Ubr7 |
C |
A |
12: 102,735,450 (GRCm39) |
T303N |
probably damaging |
Het |
| Ushbp1 |
A |
T |
8: 71,842,868 (GRCm39) |
|
probably null |
Het |
| Vmn1r177 |
C |
A |
7: 23,565,475 (GRCm39) |
V134F |
probably benign |
Het |
| Vmn2r12 |
A |
G |
5: 109,235,716 (GRCm39) |
|
probably null |
Het |
| Vmn2r53 |
T |
G |
7: 12,335,141 (GRCm39) |
H173P |
probably benign |
Het |
| Yars1 |
A |
T |
4: 129,090,948 (GRCm39) |
M119L |
probably damaging |
Het |
| Zcrb1 |
A |
T |
15: 93,295,038 (GRCm39) |
|
probably benign |
Het |
| Zfp267 |
T |
A |
3: 36,218,935 (GRCm39) |
Y319* |
probably null |
Het |
| Zfp319 |
C |
A |
8: 96,056,250 (GRCm39) |
|
probably benign |
Het |
| Zfp783 |
C |
G |
6: 47,920,320 (GRCm39) |
|
noncoding transcript |
Het |
| Zfyve26 |
A |
G |
12: 79,320,372 (GRCm39) |
I1024T |
possibly damaging |
Het |
|
| Other mutations in Abcc1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00089:Abcc1
|
APN |
16 |
14,278,847 (GRCm39) |
missense |
probably benign |
0.34 |
|
IGL00094:Abcc1
|
APN |
16 |
14,288,398 (GRCm39) |
missense |
probably null |
0.00 |
|
IGL00475:Abcc1
|
APN |
16 |
14,254,437 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00516:Abcc1
|
APN |
16 |
14,231,176 (GRCm39) |
nonsense |
probably null |
|
|
IGL00765:Abcc1
|
APN |
16 |
14,229,372 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00792:Abcc1
|
APN |
16 |
14,228,790 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01678:Abcc1
|
APN |
16 |
14,222,883 (GRCm39) |
missense |
probably null |
0.96 |
|
IGL01683:Abcc1
|
APN |
16 |
14,214,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01955:Abcc1
|
APN |
16 |
14,228,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02048:Abcc1
|
APN |
16 |
14,229,383 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02345:Abcc1
|
APN |
16 |
14,214,215 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02366:Abcc1
|
APN |
16 |
14,285,843 (GRCm39) |
splice site |
probably benign |
|
|
IGL02431:Abcc1
|
APN |
16 |
14,237,598 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02480:Abcc1
|
APN |
16 |
14,221,869 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL02651:Abcc1
|
APN |
16 |
14,283,990 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02902:Abcc1
|
APN |
16 |
14,240,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03101:Abcc1
|
APN |
16 |
14,207,732 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03230:Abcc1
|
APN |
16 |
14,275,811 (GRCm39) |
missense |
probably benign |
|
|
IGL03308:Abcc1
|
APN |
16 |
14,288,475 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
gloom
|
UTSW |
16 |
14,229,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
loom
|
UTSW |
16 |
14,290,794 (GRCm39) |
missense |
probably damaging |
0.96 |
|
PIT4544001:Abcc1
|
UTSW |
16 |
14,222,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0310:Abcc1
|
UTSW |
16 |
14,228,791 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0594:Abcc1
|
UTSW |
16 |
14,207,744 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0928:Abcc1
|
UTSW |
16 |
14,207,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1367:Abcc1
|
UTSW |
16 |
14,261,250 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1496:Abcc1
|
UTSW |
16 |
14,266,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1643:Abcc1
|
UTSW |
16 |
14,231,232 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1795:Abcc1
|
UTSW |
16 |
14,283,001 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R1834:Abcc1
|
UTSW |
16 |
14,240,981 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1847:Abcc1
|
UTSW |
16 |
14,263,313 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1959:Abcc1
|
UTSW |
16 |
14,214,257 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1961:Abcc1
|
UTSW |
16 |
14,214,257 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2017:Abcc1
|
UTSW |
16 |
14,279,068 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2224:Abcc1
|
UTSW |
16 |
14,289,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2377:Abcc1
|
UTSW |
16 |
14,285,787 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2513:Abcc1
|
UTSW |
16 |
14,290,873 (GRCm39) |
splice site |
probably null |
|
|
R2876:Abcc1
|
UTSW |
16 |
14,275,824 (GRCm39) |
missense |
probably benign |
|
|
R3003:Abcc1
|
UTSW |
16 |
14,254,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3941:Abcc1
|
UTSW |
16 |
14,214,263 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4119:Abcc1
|
UTSW |
16 |
14,211,877 (GRCm39) |
missense |
probably benign |
0.43 |
|
R4191:Abcc1
|
UTSW |
16 |
14,207,728 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4369:Abcc1
|
UTSW |
16 |
14,278,857 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4428:Abcc1
|
UTSW |
16 |
14,263,164 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4589:Abcc1
|
UTSW |
16 |
14,211,895 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4779:Abcc1
|
UTSW |
16 |
14,228,635 (GRCm39) |
missense |
probably benign |
0.35 |
|
R5027:Abcc1
|
UTSW |
16 |
14,221,917 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5275:Abcc1
|
UTSW |
16 |
14,284,050 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5418:Abcc1
|
UTSW |
16 |
14,278,996 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5490:Abcc1
|
UTSW |
16 |
14,228,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5527:Abcc1
|
UTSW |
16 |
14,278,842 (GRCm39) |
missense |
probably benign |
0.18 |
|
R5641:Abcc1
|
UTSW |
16 |
14,289,877 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5642:Abcc1
|
UTSW |
16 |
14,261,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5875:Abcc1
|
UTSW |
16 |
14,284,901 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5916:Abcc1
|
UTSW |
16 |
14,283,006 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6112:Abcc1
|
UTSW |
16 |
14,278,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6331:Abcc1
|
UTSW |
16 |
14,282,920 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6464:Abcc1
|
UTSW |
16 |
14,265,354 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6950:Abcc1
|
UTSW |
16 |
14,229,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7024:Abcc1
|
UTSW |
16 |
14,231,247 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7115:Abcc1
|
UTSW |
16 |
14,255,589 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7187:Abcc1
|
UTSW |
16 |
14,284,861 (GRCm39) |
missense |
probably benign |
|
|
R7298:Abcc1
|
UTSW |
16 |
14,214,336 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7342:Abcc1
|
UTSW |
16 |
14,283,033 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7474:Abcc1
|
UTSW |
16 |
14,290,850 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7488:Abcc1
|
UTSW |
16 |
14,207,763 (GRCm39) |
nonsense |
probably null |
|
|
R7583:Abcc1
|
UTSW |
16 |
14,221,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7619:Abcc1
|
UTSW |
16 |
14,263,283 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7971:Abcc1
|
UTSW |
16 |
14,266,443 (GRCm39) |
missense |
probably benign |
|
|
R8048:Abcc1
|
UTSW |
16 |
14,228,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8138:Abcc1
|
UTSW |
16 |
14,290,751 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8159:Abcc1
|
UTSW |
16 |
14,290,794 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8319:Abcc1
|
UTSW |
16 |
14,214,315 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8859:Abcc1
|
UTSW |
16 |
14,214,225 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8980:Abcc1
|
UTSW |
16 |
14,278,961 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9480:Abcc1
|
UTSW |
16 |
14,211,889 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9519:Abcc1
|
UTSW |
16 |
14,207,681 (GRCm39) |
missense |
probably benign |
|
|
R9653:Abcc1
|
UTSW |
16 |
14,214,257 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9708:Abcc1
|
UTSW |
16 |
14,254,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9725:Abcc1
|
UTSW |
16 |
14,290,797 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R9786:Abcc1
|
UTSW |
16 |
14,222,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0026:Abcc1
|
UTSW |
16 |
14,277,766 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Z1088:Abcc1
|
UTSW |
16 |
14,228,673 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Abcc1
|
UTSW |
16 |
14,229,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGCCTTGTTGTCTCCACCTAAACAC -3'
(R):5'- GCCACCAAGCTATCTTTCCAGATCC -3'
Sequencing Primer
(F):5'- TTTATAGATGGCACACAGGACAC -3'
(R):5'- ctgcaatttgctaagtaatcaagg -3'
|
| Posted On |
2013-11-08 |
Incidental Mutation