Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01373:Vmn2r13'

84071

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r13

Ensembl Gene

ENSMUSG00000091635

Gene Name

vomeronasal 2, receptor 13

Synonyms

Gm4867

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.079) question?

Stock #

IGL01373

Quality Score

Status

Chromosome

Chromosomal Location

109156068-109192107 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 109156702 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Phenylalanine at position 621 (Y621F)

Ref Sequence

ENSEMBL: ENSMUSP00000052977 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000053253]

AlphaFold

L7N1X2

Predicted Effect

probably damaging
Transcript: ENSMUST00000053253
AA Change: Y621F

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000052977
Gene: ENSMUSG00000091635
AA Change: Y621F

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	76	463	2.8e-29	PFAM
Pfam:NCD3G	506	560	1.3e-18	PFAM
Pfam:7tm_3	593	828	1.8e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsm4	C	T	7: 119,711,419	R510*	probably null	Het
Adamts12	A	T	15: 11,310,730	E1024D	probably benign	Het
Aff2	T	A	X: 69,867,729	D1239E	possibly damaging	Het
Agps	T	C	2: 75,852,784	V151A	probably benign	Het
Cables1	A	T	18: 11,888,764	R276S	probably damaging	Het
Cep72	A	G	13: 74,059,459	S64P	probably damaging	Het
Cmah	A	T	13: 24,430,549	D159V	probably damaging	Het
Cox6a1	C	A	5: 115,345,839		probably benign	Het
Cpxm1	T	C	2: 130,394,135	E369G	probably damaging	Het
Dnah6	A	G	6: 73,074,748	L3021P	probably benign	Het
Esyt1	T	C	10: 128,518,941	E530G	possibly damaging	Het
Fancd2	A	G	6: 113,553,752	I449V	probably benign	Het
Fbxw24	C	T	9: 109,623,633	G98D	probably damaging	Het
Folh1	T	C	7: 86,746,142	I361V	probably benign	Het
Gm12666	A	G	4: 92,191,625	V42A	probably damaging	Het
Gpr19	T	A	6: 134,870,321	H41L	possibly damaging	Het
Kcnq4	A	G	4: 120,717,032	V143A	probably damaging	Het
Lmcd1	A	G	6: 112,310,625	I91V	probably benign	Het
Lpin3	G	T	2: 160,903,729	D651Y	probably damaging	Het
Ms4a6b	A	T	19: 11,529,507	H220L	possibly damaging	Het
Mxd4	G	A	5: 34,184,346		probably benign	Het
Nxnl2	T	C	13: 51,171,452	F44L	probably damaging	Het
Olfr698	T	C	7: 106,752,446		probably benign	Het
Olfr744	T	A	14: 50,618,612	I130N	probably damaging	Het
Pcdhb20	A	T	18: 37,506,568	R716W	probably benign	Het
Pcx	T	A	19: 4,620,235		probably null	Het
Plekhf1	T	C	7: 38,221,797	T116A	probably benign	Het
Psmb2	G	T	4: 126,687,092	R93L	probably damaging	Het
Pstpip2	T	A	18: 77,835,216	L42*	probably null	Het
Ptpn22	A	T	3: 103,886,204	D557V	probably damaging	Het
Rbbp5	G	A	1: 132,492,601	V191I	probably benign	Het
Rgs1	T	A	1: 144,245,378	D185V	probably damaging	Het
Selenoh	A	G	2: 84,670,594		probably benign	Het
Slc6a5	C	T	7: 49,917,733	P312S	probably benign	Het
Snapc1	T	A	12: 73,964,680	M40K	probably benign	Het
Sptbn2	T	G	19: 4,745,972	Y1726*	probably null	Het
Syne2	T	C	12: 75,987,107	I3710T	probably damaging	Het
Tdrd9	G	A	12: 112,040,434	V911M	probably damaging	Het
Tex9	A	T	9: 72,480,754	D134E	possibly damaging	Het
Ttc41	G	T	10: 86,775,957	C1063F	possibly damaging	Het
Usp38	C	A	8: 80,990,018	A496S	possibly damaging	Het
Vmn2r67	T	A	7: 85,136,626	M724L	probably benign	Het

Other mutations in Vmn2r13

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00965:Vmn2r13	APN	5	109156098	missense	probably damaging	1.00
IGL01946:Vmn2r13	APN	5	109174219	missense	probably benign	0.01
IGL01971:Vmn2r13	APN	5	109174115	missense	probably benign	0.01
IGL02636:Vmn2r13	APN	5	109192017	missense	probably damaging	0.98
IGL03062:Vmn2r13	APN	5	109156282	missense	probably damaging	1.00
IGL03173:Vmn2r13	APN	5	109171779	missense	possibly damaging	0.95
IGL03301:Vmn2r13	APN	5	109158089	missense	probably damaging	0.99
IGL03383:Vmn2r13	APN	5	109156532	missense	probably damaging	0.98
IGL03048:Vmn2r13	UTSW	5	109156285	missense	probably damaging	1.00
R0123:Vmn2r13	UTSW	5	109175049	missense	probably benign	0.00
R0134:Vmn2r13	UTSW	5	109175049	missense	probably benign	0.00
R0220:Vmn2r13	UTSW	5	109156466	missense	probably damaging	1.00
R0225:Vmn2r13	UTSW	5	109175049	missense	probably benign	0.00
R0393:Vmn2r13	UTSW	5	109156529	missense	probably benign	0.01
R0410:Vmn2r13	UTSW	5	109173813	missense	probably benign	0.35
R0787:Vmn2r13	UTSW	5	109156847	missense	probably damaging	0.99
R1200:Vmn2r13	UTSW	5	109174202	missense	probably damaging	1.00
R1448:Vmn2r13	UTSW	5	109174135	missense	probably damaging	1.00
R1782:Vmn2r13	UTSW	5	109158174	missense	probably benign	0.08
R1939:Vmn2r13	UTSW	5	109191986	missense	possibly damaging	0.88
R2029:Vmn2r13	UTSW	5	109192077	missense	probably benign	0.13
R2125:Vmn2r13	UTSW	5	109158192	missense	probably benign	0.00
R2126:Vmn2r13	UTSW	5	109158192	missense	probably benign	0.00
R2379:Vmn2r13	UTSW	5	109171778	missense	probably benign	0.05
R2680:Vmn2r13	UTSW	5	109174312	missense	possibly damaging	0.66
R2888:Vmn2r13	UTSW	5	109191974	missense	possibly damaging	0.88
R2889:Vmn2r13	UTSW	5	109191974	missense	possibly damaging	0.88
R2890:Vmn2r13	UTSW	5	109191974	missense	possibly damaging	0.88
R3014:Vmn2r13	UTSW	5	109171761	missense	possibly damaging	0.81
R3683:Vmn2r13	UTSW	5	109156855	missense	probably damaging	1.00
R4074:Vmn2r13	UTSW	5	109156700	missense	probably damaging	1.00
R4599:Vmn2r13	UTSW	5	109156456	missense	probably damaging	1.00
R4614:Vmn2r13	UTSW	5	109175199	missense	probably benign	0.01
R4805:Vmn2r13	UTSW	5	109156465	missense	probably damaging	1.00
R4822:Vmn2r13	UTSW	5	109174072	missense	probably damaging	0.99
R4943:Vmn2r13	UTSW	5	109175049	missense	probably benign	0.00
R5263:Vmn2r13	UTSW	5	109173975	missense	probably benign	0.00
R5297:Vmn2r13	UTSW	5	109191939	missense	probably benign	0.00
R5502:Vmn2r13	UTSW	5	109173714	missense	probably damaging	1.00
R5554:Vmn2r13	UTSW	5	109191994	missense	possibly damaging	0.49
R5563:Vmn2r13	UTSW	5	109173980	missense	probably benign	0.00
R5819:Vmn2r13	UTSW	5	109174100	missense	possibly damaging	0.79
R6074:Vmn2r13	UTSW	5	109174301	missense	probably benign	0.04
R6416:Vmn2r13	UTSW	5	109174116	missense	probably damaging	0.99
R6419:Vmn2r13	UTSW	5	109175219	missense	possibly damaging	0.87
R6484:Vmn2r13	UTSW	5	109156674	nonsense	probably null
R6486:Vmn2r13	UTSW	5	109156559	missense	probably benign	0.05
R6545:Vmn2r13	UTSW	5	109156940	splice site	probably null
R6700:Vmn2r13	UTSW	5	109175072	missense	probably benign	0.00
R6897:Vmn2r13	UTSW	5	109158149	missense	possibly damaging	0.90
R6957:Vmn2r13	UTSW	5	109156887	nonsense	probably null
R7276:Vmn2r13	UTSW	5	109173779	missense	probably damaging	1.00
R7363:Vmn2r13	UTSW	5	109192043	missense	probably benign	0.03
R7443:Vmn2r13	UTSW	5	109192043	missense	probably benign	0.03
R7555:Vmn2r13	UTSW	5	109171691	splice site	probably null
R7607:Vmn2r13	UTSW	5	109173640	missense	probably damaging	0.98
R7719:Vmn2r13	UTSW	5	109171752	missense	probably benign	0.00
R8116:Vmn2r13	UTSW	5	109175060	missense	probably benign	0.12
R8242:Vmn2r13	UTSW	5	109175006	missense	possibly damaging	0.65
R8294:Vmn2r13	UTSW	5	109175112	missense	probably benign	0.02
R8340:Vmn2r13	UTSW	5	109174140	missense	probably benign	0.00
R8692:Vmn2r13	UTSW	5	109171648	missense	probably benign	0.03
R8742:Vmn2r13	UTSW	5	109156397	missense	probably benign	0.02
R9022:Vmn2r13	UTSW	5	109156376	missense	possibly damaging	0.94
R9281:Vmn2r13	UTSW	5	109156087	missense	probably damaging	1.00
R9529:Vmn2r13	UTSW	5	109156198	missense	probably damaging	1.00
R9708:Vmn2r13	UTSW	5	109174141	missense	probably benign	0.00
R9746:Vmn2r13	UTSW	5	109191907	critical splice donor site	probably null
X0066:Vmn2r13	UTSW	5	109156219	missense	probably benign	0.44

Posted On

2013-11-11