Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01373:Vmn2r13'

84071

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r13

Ensembl Gene

ENSMUSG00000091635

Gene Name

vomeronasal 2, receptor 13

Synonyms

Gm4867

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.075) question?

Stock #

IGL01373

Quality Score

Status

Chromosome

Chromosomal Location

109303889-109339973 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 109304568 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Phenylalanine at position 621 (Y621F)

Ref Sequence

ENSEMBL: ENSMUSP00000052977 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000053253]

AlphaFold

L7N1X2

Predicted Effect

probably damaging
Transcript: ENSMUST00000053253
AA Change: Y621F

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000052977
Gene: ENSMUSG00000091635
AA Change: Y621F

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	76	463	2.8e-29	PFAM
Pfam:NCD3G	506	560	1.3e-18	PFAM
Pfam:7tm_3	593	828	1.8e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsm4	C	T	7: 119,310,642 (GRCm39)	R510*	probably null	Het
Adamts12	A	T	15: 11,310,816 (GRCm39)	E1024D	probably benign	Het
Aff2	T	A	X: 68,911,335 (GRCm39)	D1239E	possibly damaging	Het
Agps	T	C	2: 75,683,128 (GRCm39)	V151A	probably benign	Het
Cables1	A	T	18: 12,021,821 (GRCm39)	R276S	probably damaging	Het
Cep72	A	G	13: 74,207,578 (GRCm39)	S64P	probably damaging	Het
Cmah	A	T	13: 24,614,532 (GRCm39)	D159V	probably damaging	Het
Cox6a1	C	A	5: 115,483,898 (GRCm39)		probably benign	Het
Cpxm1	T	C	2: 130,236,055 (GRCm39)	E369G	probably damaging	Het
Dnah6	A	G	6: 73,051,731 (GRCm39)	L3021P	probably benign	Het
Esyt1	T	C	10: 128,354,810 (GRCm39)	E530G	possibly damaging	Het
Fancd2	A	G	6: 113,530,713 (GRCm39)	I449V	probably benign	Het
Fbxw24	C	T	9: 109,452,701 (GRCm39)	G98D	probably damaging	Het
Folh1	T	C	7: 86,395,350 (GRCm39)	I361V	probably benign	Het
Gpr19	T	A	6: 134,847,284 (GRCm39)	H41L	possibly damaging	Het
Kcnq4	A	G	4: 120,574,229 (GRCm39)	V143A	probably damaging	Het
Larp7-ps	A	G	4: 92,079,862 (GRCm39)	V42A	probably damaging	Het
Lmcd1	A	G	6: 112,287,586 (GRCm39)	I91V	probably benign	Het
Lpin3	G	T	2: 160,745,649 (GRCm39)	D651Y	probably damaging	Het
Ms4a6b	A	T	19: 11,506,871 (GRCm39)	H220L	possibly damaging	Het
Mxd4	G	A	5: 34,341,690 (GRCm39)		probably benign	Het
Nxnl2	T	C	13: 51,325,488 (GRCm39)	F44L	probably damaging	Het
Or11g2	T	A	14: 50,856,069 (GRCm39)	I130N	probably damaging	Het
Or2ag16	T	C	7: 106,351,653 (GRCm39)		probably benign	Het
Pcdhb20	A	T	18: 37,639,621 (GRCm39)	R716W	probably benign	Het
Pcx	T	A	19: 4,670,263 (GRCm39)		probably null	Het
Plekhf1	T	C	7: 37,921,221 (GRCm39)	T116A	probably benign	Het
Psmb2	G	T	4: 126,580,885 (GRCm39)	R93L	probably damaging	Het
Pstpip2	T	A	18: 77,922,916 (GRCm39)	L42*	probably null	Het
Ptpn22	A	T	3: 103,793,520 (GRCm39)	D557V	probably damaging	Het
Rbbp5	G	A	1: 132,420,339 (GRCm39)	V191I	probably benign	Het
Rgs1	T	A	1: 144,121,116 (GRCm39)	D185V	probably damaging	Het
Selenoh	A	G	2: 84,500,938 (GRCm39)		probably benign	Het
Slc6a5	C	T	7: 49,567,481 (GRCm39)	P312S	probably benign	Het
Snapc1	T	A	12: 74,011,454 (GRCm39)	M40K	probably benign	Het
Sptbn2	T	G	19: 4,796,000 (GRCm39)	Y1726*	probably null	Het
Syne2	T	C	12: 76,033,881 (GRCm39)	I3710T	probably damaging	Het
Tdrd9	G	A	12: 112,006,868 (GRCm39)	V911M	probably damaging	Het
Tex9	A	T	9: 72,388,036 (GRCm39)	D134E	possibly damaging	Het
Ttc41	G	T	10: 86,611,821 (GRCm39)	C1063F	possibly damaging	Het
Usp38	C	A	8: 81,716,647 (GRCm39)	A496S	possibly damaging	Het
Vmn2r67	T	A	7: 84,785,834 (GRCm39)	M724L	probably benign	Het

Other mutations in Vmn2r13

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00965:Vmn2r13	APN	5	109,303,964 (GRCm39)	missense	probably damaging	1.00
IGL01946:Vmn2r13	APN	5	109,322,085 (GRCm39)	missense	probably benign	0.01
IGL01971:Vmn2r13	APN	5	109,321,981 (GRCm39)	missense	probably benign	0.01
IGL02636:Vmn2r13	APN	5	109,339,883 (GRCm39)	missense	probably damaging	0.98
IGL03062:Vmn2r13	APN	5	109,304,148 (GRCm39)	missense	probably damaging	1.00
IGL03173:Vmn2r13	APN	5	109,319,645 (GRCm39)	missense	possibly damaging	0.95
IGL03301:Vmn2r13	APN	5	109,305,955 (GRCm39)	missense	probably damaging	0.99
IGL03383:Vmn2r13	APN	5	109,304,398 (GRCm39)	missense	probably damaging	0.98
IGL03048:Vmn2r13	UTSW	5	109,304,151 (GRCm39)	missense	probably damaging	1.00
R0123:Vmn2r13	UTSW	5	109,322,915 (GRCm39)	missense	probably benign	0.00
R0134:Vmn2r13	UTSW	5	109,322,915 (GRCm39)	missense	probably benign	0.00
R0220:Vmn2r13	UTSW	5	109,304,332 (GRCm39)	missense	probably damaging	1.00
R0225:Vmn2r13	UTSW	5	109,322,915 (GRCm39)	missense	probably benign	0.00
R0393:Vmn2r13	UTSW	5	109,304,395 (GRCm39)	missense	probably benign	0.01
R0410:Vmn2r13	UTSW	5	109,321,679 (GRCm39)	missense	probably benign	0.35
R0787:Vmn2r13	UTSW	5	109,304,713 (GRCm39)	missense	probably damaging	0.99
R1200:Vmn2r13	UTSW	5	109,322,068 (GRCm39)	missense	probably damaging	1.00
R1448:Vmn2r13	UTSW	5	109,322,001 (GRCm39)	missense	probably damaging	1.00
R1782:Vmn2r13	UTSW	5	109,306,040 (GRCm39)	missense	probably benign	0.08
R1939:Vmn2r13	UTSW	5	109,339,852 (GRCm39)	missense	possibly damaging	0.88
R2029:Vmn2r13	UTSW	5	109,339,943 (GRCm39)	missense	probably benign	0.13
R2125:Vmn2r13	UTSW	5	109,306,058 (GRCm39)	missense	probably benign	0.00
R2126:Vmn2r13	UTSW	5	109,306,058 (GRCm39)	missense	probably benign	0.00
R2379:Vmn2r13	UTSW	5	109,319,644 (GRCm39)	missense	probably benign	0.05
R2680:Vmn2r13	UTSW	5	109,322,178 (GRCm39)	missense	possibly damaging	0.66
R2888:Vmn2r13	UTSW	5	109,339,840 (GRCm39)	missense	possibly damaging	0.88
R2889:Vmn2r13	UTSW	5	109,339,840 (GRCm39)	missense	possibly damaging	0.88
R2890:Vmn2r13	UTSW	5	109,339,840 (GRCm39)	missense	possibly damaging	0.88
R3014:Vmn2r13	UTSW	5	109,319,627 (GRCm39)	missense	possibly damaging	0.81
R3683:Vmn2r13	UTSW	5	109,304,721 (GRCm39)	missense	probably damaging	1.00
R4074:Vmn2r13	UTSW	5	109,304,566 (GRCm39)	missense	probably damaging	1.00
R4599:Vmn2r13	UTSW	5	109,304,322 (GRCm39)	missense	probably damaging	1.00
R4614:Vmn2r13	UTSW	5	109,323,065 (GRCm39)	missense	probably benign	0.01
R4805:Vmn2r13	UTSW	5	109,304,331 (GRCm39)	missense	probably damaging	1.00
R4822:Vmn2r13	UTSW	5	109,321,938 (GRCm39)	missense	probably damaging	0.99
R4943:Vmn2r13	UTSW	5	109,322,915 (GRCm39)	missense	probably benign	0.00
R5263:Vmn2r13	UTSW	5	109,321,841 (GRCm39)	missense	probably benign	0.00
R5297:Vmn2r13	UTSW	5	109,339,805 (GRCm39)	missense	probably benign	0.00
R5502:Vmn2r13	UTSW	5	109,321,580 (GRCm39)	missense	probably damaging	1.00
R5554:Vmn2r13	UTSW	5	109,339,860 (GRCm39)	missense	possibly damaging	0.49
R5563:Vmn2r13	UTSW	5	109,321,846 (GRCm39)	missense	probably benign	0.00
R5819:Vmn2r13	UTSW	5	109,321,966 (GRCm39)	missense	possibly damaging	0.79
R6074:Vmn2r13	UTSW	5	109,322,167 (GRCm39)	missense	probably benign	0.04
R6416:Vmn2r13	UTSW	5	109,321,982 (GRCm39)	missense	probably damaging	0.99
R6419:Vmn2r13	UTSW	5	109,323,085 (GRCm39)	missense	possibly damaging	0.87
R6484:Vmn2r13	UTSW	5	109,304,540 (GRCm39)	nonsense	probably null
R6486:Vmn2r13	UTSW	5	109,304,425 (GRCm39)	missense	probably benign	0.05
R6545:Vmn2r13	UTSW	5	109,304,806 (GRCm39)	splice site	probably null
R6700:Vmn2r13	UTSW	5	109,322,938 (GRCm39)	missense	probably benign	0.00
R6897:Vmn2r13	UTSW	5	109,306,015 (GRCm39)	missense	possibly damaging	0.90
R6957:Vmn2r13	UTSW	5	109,304,753 (GRCm39)	nonsense	probably null
R7276:Vmn2r13	UTSW	5	109,321,645 (GRCm39)	missense	probably damaging	1.00
R7363:Vmn2r13	UTSW	5	109,339,909 (GRCm39)	missense	probably benign	0.03
R7443:Vmn2r13	UTSW	5	109,339,909 (GRCm39)	missense	probably benign	0.03
R7555:Vmn2r13	UTSW	5	109,319,557 (GRCm39)	splice site	probably null
R7607:Vmn2r13	UTSW	5	109,321,506 (GRCm39)	missense	probably damaging	0.98
R7719:Vmn2r13	UTSW	5	109,319,618 (GRCm39)	missense	probably benign	0.00
R8116:Vmn2r13	UTSW	5	109,322,926 (GRCm39)	missense	probably benign	0.12
R8242:Vmn2r13	UTSW	5	109,322,872 (GRCm39)	missense	possibly damaging	0.65
R8294:Vmn2r13	UTSW	5	109,322,978 (GRCm39)	missense	probably benign	0.02
R8340:Vmn2r13	UTSW	5	109,322,006 (GRCm39)	missense	probably benign	0.00
R8692:Vmn2r13	UTSW	5	109,319,514 (GRCm39)	missense	probably benign	0.03
R8742:Vmn2r13	UTSW	5	109,304,263 (GRCm39)	missense	probably benign	0.02
R9022:Vmn2r13	UTSW	5	109,304,242 (GRCm39)	missense	possibly damaging	0.94
R9281:Vmn2r13	UTSW	5	109,303,953 (GRCm39)	missense	probably damaging	1.00
R9529:Vmn2r13	UTSW	5	109,304,064 (GRCm39)	missense	probably damaging	1.00
R9708:Vmn2r13	UTSW	5	109,322,007 (GRCm39)	missense	probably benign	0.00
R9746:Vmn2r13	UTSW	5	109,339,773 (GRCm39)	critical splice donor site	probably null
X0066:Vmn2r13	UTSW	5	109,304,085 (GRCm39)	missense	probably benign	0.44

Posted On

2013-11-11