Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01373:Tex9'

84090

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tex9

Ensembl Gene

ENSMUSG00000090626

Gene Name

testis expressed gene 9

Synonyms

tsec-1

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.071) question?

Stock #

IGL01373

Quality Score

Status

Chromosome

Chromosomal Location

72450394-72492212 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 72480754 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glutamic Acid at position 134 (D134E)

Ref Sequence

ENSEMBL: ENSMUSP00000139026 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000085358] [ENSMUST00000183574] [ENSMUST00000183856] [ENSMUST00000184125] [ENSMUST00000184312] [ENSMUST00000184557] [ENSMUST00000184831] [ENSMUST00000185151]

AlphaFold

Q9D845

Predicted Effect

probably benign
Transcript: ENSMUST00000085358

SMART Domains

Protein: ENSMUSP00000082467
Gene: ENSMUSG00000090626

Domain	Start	End	E-Value	Type
coiled coil region	23	63	N/A	INTRINSIC
coiled coil region	186	344	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000183428

Predicted Effect

unknown
Transcript: ENSMUST00000183501
AA Change: D53E

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000183551

Predicted Effect

probably benign
Transcript: ENSMUST00000183574
AA Change: D134E

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000139386
Gene: ENSMUSG00000090626
AA Change: D134E

Domain	Start	End	E-Value	Type
coiled coil region	23	63	N/A	INTRINSIC
coiled coil region	186	208	N/A	INTRINSIC
coiled coil region	231	286	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000183856
AA Change: D134E

PolyPhen 2 Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000139247
Gene: ENSMUSG00000090626
AA Change: D134E

Domain	Start	End	E-Value	Type
coiled coil region	23	63	N/A	INTRINSIC
coiled coil region	186	328	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000184066

Predicted Effect

possibly damaging
Transcript: ENSMUST00000184125
AA Change: D134E

PolyPhen 2 Score 0.782 (Sensitivity: 0.85; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000139026
Gene: ENSMUSG00000090626
AA Change: D134E

Domain	Start	End	E-Value	Type
coiled coil region	23	63	N/A	INTRINSIC
coiled coil region	186	344	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000184312

SMART Domains

Protein: ENSMUSP00000138844
Gene: ENSMUSG00000090626

Domain	Start	End	E-Value	Type
coiled coil region	23	63	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000184557
AA Change: D134E

PolyPhen 2 Score 0.725 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000139212
Gene: ENSMUSG00000090626
AA Change: D134E

Domain	Start	End	E-Value	Type
coiled coil region	23	63	N/A	INTRINSIC
coiled coil region	186	280	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000184624

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000185106

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000184734

Predicted Effect

probably benign
Transcript: ENSMUST00000184831

SMART Domains

Protein: ENSMUSP00000138999
Gene: ENSMUSG00000090626

Domain	Start	End	E-Value	Type
coiled coil region	1	159	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000185151

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsm4	C	T	7: 119,711,419	R510*	probably null	Het
Adamts12	A	T	15: 11,310,730	E1024D	probably benign	Het
Aff2	T	A	X: 69,867,729	D1239E	possibly damaging	Het
Agps	T	C	2: 75,852,784	V151A	probably benign	Het
Cables1	A	T	18: 11,888,764	R276S	probably damaging	Het
Cep72	A	G	13: 74,059,459	S64P	probably damaging	Het
Cmah	A	T	13: 24,430,549	D159V	probably damaging	Het
Cox6a1	C	A	5: 115,345,839		probably benign	Het
Cpxm1	T	C	2: 130,394,135	E369G	probably damaging	Het
Dnah6	A	G	6: 73,074,748	L3021P	probably benign	Het
Esyt1	T	C	10: 128,518,941	E530G	possibly damaging	Het
Fancd2	A	G	6: 113,553,752	I449V	probably benign	Het
Fbxw24	C	T	9: 109,623,633	G98D	probably damaging	Het
Folh1	T	C	7: 86,746,142	I361V	probably benign	Het
Gm12666	A	G	4: 92,191,625	V42A	probably damaging	Het
Gpr19	T	A	6: 134,870,321	H41L	possibly damaging	Het
Kcnq4	A	G	4: 120,717,032	V143A	probably damaging	Het
Lmcd1	A	G	6: 112,310,625	I91V	probably benign	Het
Lpin3	G	T	2: 160,903,729	D651Y	probably damaging	Het
Ms4a6b	A	T	19: 11,529,507	H220L	possibly damaging	Het
Mxd4	G	A	5: 34,184,346		probably benign	Het
Nxnl2	T	C	13: 51,171,452	F44L	probably damaging	Het
Olfr698	T	C	7: 106,752,446		probably benign	Het
Olfr744	T	A	14: 50,618,612	I130N	probably damaging	Het
Pcdhb20	A	T	18: 37,506,568	R716W	probably benign	Het
Pcx	T	A	19: 4,620,235		probably null	Het
Plekhf1	T	C	7: 38,221,797	T116A	probably benign	Het
Psmb2	G	T	4: 126,687,092	R93L	probably damaging	Het
Pstpip2	T	A	18: 77,835,216	L42*	probably null	Het
Ptpn22	A	T	3: 103,886,204	D557V	probably damaging	Het
Rbbp5	G	A	1: 132,492,601	V191I	probably benign	Het
Rgs1	T	A	1: 144,245,378	D185V	probably damaging	Het
Selenoh	A	G	2: 84,670,594		probably benign	Het
Slc6a5	C	T	7: 49,917,733	P312S	probably benign	Het
Snapc1	T	A	12: 73,964,680	M40K	probably benign	Het
Sptbn2	T	G	19: 4,745,972	Y1726*	probably null	Het
Syne2	T	C	12: 75,987,107	I3710T	probably damaging	Het
Tdrd9	G	A	12: 112,040,434	V911M	probably damaging	Het
Ttc41	G	T	10: 86,775,957	C1063F	possibly damaging	Het
Usp38	C	A	8: 80,990,018	A496S	possibly damaging	Het
Vmn2r13	T	A	5: 109,156,702	Y621F	probably damaging	Het
Vmn2r67	T	A	7: 85,136,626	M724L	probably benign	Het

Other mutations in Tex9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00467:Tex9	APN	9	72477835	missense	probably benign	0.32
IGL01109:Tex9	APN	9	72488067	missense	probably damaging	1.00
IGL02496:Tex9	APN	9	72482492	missense	probably benign	0.25
IGL02569:Tex9	APN	9	72478363	missense	probably damaging	1.00
barbacoa	UTSW	9	72486778	critical splice donor site	probably null
R0068:Tex9	UTSW	9	72486769	splice site	probably benign
R0481:Tex9	UTSW	9	72478396	nonsense	probably null
R0628:Tex9	UTSW	9	72491951	start codon destroyed	probably null	0.99
R0962:Tex9	UTSW	9	72484092	missense	probably benign
R2212:Tex9	UTSW	9	72477758	missense	possibly damaging	0.89
R3412:Tex9	UTSW	9	72477758	missense	possibly damaging	0.89
R4373:Tex9	UTSW	9	72480595	critical splice donor site	probably null
R4972:Tex9	UTSW	9	72478338	critical splice donor site	probably null
R5323:Tex9	UTSW	9	72477905	missense	probably damaging	1.00
R5401:Tex9	UTSW	9	72486778	critical splice donor site	probably null
R6149:Tex9	UTSW	9	72462000	splice site	probably null
R7396:Tex9	UTSW	9	72480790	splice site	probably null
R7412:Tex9	UTSW	9	72486778	critical splice donor site	probably null
R8198:Tex9	UTSW	9	72480658	start gained	probably benign
R8745:Tex9	UTSW	9	72482496	missense	probably benign	0.00
R9767:Tex9	UTSW	9	72461236	nonsense	probably null
X0024:Tex9	UTSW	9	72480674	missense	probably damaging	1.00

Posted On

2013-11-11