Incidental Mutation 'IGL01373:Tex9'
ID 84090
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tex9
Ensembl Gene ENSMUSG00000090626
Gene Name testis expressed gene 9
Synonyms tsec-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.071) question?
Stock # IGL01373
Quality Score
Status
Chromosome 9
Chromosomal Location 72450394-72492212 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 72480754 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 134 (D134E)
Ref Sequence ENSEMBL: ENSMUSP00000139026 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085358] [ENSMUST00000183574] [ENSMUST00000183856] [ENSMUST00000184125] [ENSMUST00000184312] [ENSMUST00000184557] [ENSMUST00000184831] [ENSMUST00000185151]
AlphaFold Q9D845
Predicted Effect probably benign
Transcript: ENSMUST00000085358
SMART Domains Protein: ENSMUSP00000082467
Gene: ENSMUSG00000090626

DomainStartEndE-ValueType
coiled coil region 23 63 N/A INTRINSIC
coiled coil region 186 344 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000183428
Predicted Effect unknown
Transcript: ENSMUST00000183501
AA Change: D53E
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183551
Predicted Effect probably benign
Transcript: ENSMUST00000183574
AA Change: D134E

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000139386
Gene: ENSMUSG00000090626
AA Change: D134E

DomainStartEndE-ValueType
coiled coil region 23 63 N/A INTRINSIC
coiled coil region 186 208 N/A INTRINSIC
coiled coil region 231 286 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000183856
AA Change: D134E

PolyPhen 2 Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000139247
Gene: ENSMUSG00000090626
AA Change: D134E

DomainStartEndE-ValueType
coiled coil region 23 63 N/A INTRINSIC
coiled coil region 186 328 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184066
Predicted Effect possibly damaging
Transcript: ENSMUST00000184125
AA Change: D134E

PolyPhen 2 Score 0.782 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000139026
Gene: ENSMUSG00000090626
AA Change: D134E

DomainStartEndE-ValueType
coiled coil region 23 63 N/A INTRINSIC
coiled coil region 186 344 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000184312
SMART Domains Protein: ENSMUSP00000138844
Gene: ENSMUSG00000090626

DomainStartEndE-ValueType
coiled coil region 23 63 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000184557
AA Change: D134E

PolyPhen 2 Score 0.725 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000139212
Gene: ENSMUSG00000090626
AA Change: D134E

DomainStartEndE-ValueType
coiled coil region 23 63 N/A INTRINSIC
coiled coil region 186 280 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184624
Predicted Effect noncoding transcript
Transcript: ENSMUST00000185106
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184734
Predicted Effect probably benign
Transcript: ENSMUST00000184831
SMART Domains Protein: ENSMUSP00000138999
Gene: ENSMUSG00000090626

DomainStartEndE-ValueType
coiled coil region 1 159 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000185151
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsm4 C T 7: 119,711,419 R510* probably null Het
Adamts12 A T 15: 11,310,730 E1024D probably benign Het
Aff2 T A X: 69,867,729 D1239E possibly damaging Het
Agps T C 2: 75,852,784 V151A probably benign Het
Cables1 A T 18: 11,888,764 R276S probably damaging Het
Cep72 A G 13: 74,059,459 S64P probably damaging Het
Cmah A T 13: 24,430,549 D159V probably damaging Het
Cox6a1 C A 5: 115,345,839 probably benign Het
Cpxm1 T C 2: 130,394,135 E369G probably damaging Het
Dnah6 A G 6: 73,074,748 L3021P probably benign Het
Esyt1 T C 10: 128,518,941 E530G possibly damaging Het
Fancd2 A G 6: 113,553,752 I449V probably benign Het
Fbxw24 C T 9: 109,623,633 G98D probably damaging Het
Folh1 T C 7: 86,746,142 I361V probably benign Het
Gm12666 A G 4: 92,191,625 V42A probably damaging Het
Gpr19 T A 6: 134,870,321 H41L possibly damaging Het
Kcnq4 A G 4: 120,717,032 V143A probably damaging Het
Lmcd1 A G 6: 112,310,625 I91V probably benign Het
Lpin3 G T 2: 160,903,729 D651Y probably damaging Het
Ms4a6b A T 19: 11,529,507 H220L possibly damaging Het
Mxd4 G A 5: 34,184,346 probably benign Het
Nxnl2 T C 13: 51,171,452 F44L probably damaging Het
Olfr698 T C 7: 106,752,446 probably benign Het
Olfr744 T A 14: 50,618,612 I130N probably damaging Het
Pcdhb20 A T 18: 37,506,568 R716W probably benign Het
Pcx T A 19: 4,620,235 probably null Het
Plekhf1 T C 7: 38,221,797 T116A probably benign Het
Psmb2 G T 4: 126,687,092 R93L probably damaging Het
Pstpip2 T A 18: 77,835,216 L42* probably null Het
Ptpn22 A T 3: 103,886,204 D557V probably damaging Het
Rbbp5 G A 1: 132,492,601 V191I probably benign Het
Rgs1 T A 1: 144,245,378 D185V probably damaging Het
Selenoh A G 2: 84,670,594 probably benign Het
Slc6a5 C T 7: 49,917,733 P312S probably benign Het
Snapc1 T A 12: 73,964,680 M40K probably benign Het
Sptbn2 T G 19: 4,745,972 Y1726* probably null Het
Syne2 T C 12: 75,987,107 I3710T probably damaging Het
Tdrd9 G A 12: 112,040,434 V911M probably damaging Het
Ttc41 G T 10: 86,775,957 C1063F possibly damaging Het
Usp38 C A 8: 80,990,018 A496S possibly damaging Het
Vmn2r13 T A 5: 109,156,702 Y621F probably damaging Het
Vmn2r67 T A 7: 85,136,626 M724L probably benign Het
Other mutations in Tex9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00467:Tex9 APN 9 72477835 missense probably benign 0.32
IGL01109:Tex9 APN 9 72488067 missense probably damaging 1.00
IGL02496:Tex9 APN 9 72482492 missense probably benign 0.25
IGL02569:Tex9 APN 9 72478363 missense probably damaging 1.00
barbacoa UTSW 9 72486778 critical splice donor site probably null
R0068:Tex9 UTSW 9 72486769 splice site probably benign
R0481:Tex9 UTSW 9 72478396 nonsense probably null
R0628:Tex9 UTSW 9 72491951 start codon destroyed probably null 0.99
R0962:Tex9 UTSW 9 72484092 missense probably benign
R2212:Tex9 UTSW 9 72477758 missense possibly damaging 0.89
R3412:Tex9 UTSW 9 72477758 missense possibly damaging 0.89
R4373:Tex9 UTSW 9 72480595 critical splice donor site probably null
R4972:Tex9 UTSW 9 72478338 critical splice donor site probably null
R5323:Tex9 UTSW 9 72477905 missense probably damaging 1.00
R5401:Tex9 UTSW 9 72486778 critical splice donor site probably null
R6149:Tex9 UTSW 9 72462000 splice site probably null
R7396:Tex9 UTSW 9 72480790 splice site probably null
R7412:Tex9 UTSW 9 72486778 critical splice donor site probably null
R8198:Tex9 UTSW 9 72480658 start gained probably benign
R8745:Tex9 UTSW 9 72482496 missense probably benign 0.00
R9767:Tex9 UTSW 9 72461236 nonsense probably null
X0024:Tex9 UTSW 9 72480674 missense probably damaging 1.00
Posted On 2013-11-11