Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01373:Gpr19'

84094

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpr19

Ensembl Gene

ENSMUSG00000032641

Gene Name

G protein-coupled receptor 19

Synonyms

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01373

Quality Score

Status

Chromosome

Chromosomal Location

134846055-134875157 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 134847284 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Leucine at position 41 (H41L)

Ref Sequence

ENSEMBL: ENSMUSP00000144918 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000046255] [ENSMUST00000066107] [ENSMUST00000111932] [ENSMUST00000116515] [ENSMUST00000165392] [ENSMUST00000203409] [ENSMUST00000203762] [ENSMUST00000204880] [ENSMUST00000215088]

AlphaFold

Q61121

Predicted Effect

probably benign
Transcript: ENSMUST00000046255
AA Change: H47L

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)

SMART Domains

Protein: ENSMUSP00000047630
Gene: ENSMUSG00000032641
AA Change: H47L

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	76	345	1.7e-12	PFAM
Pfam:7tm_1	82	330	1.8e-50	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000066107
AA Change: H133L

PolyPhen 2 Score 0.203 (Sensitivity: 0.92; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000066287
Gene: ENSMUSG00000032641
AA Change: H133L

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	76	345	1.7e-12	PFAM
Pfam:7tm_1	82	330	5.3e-45	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000111932
AA Change: H41L

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)

SMART Domains

Protein: ENSMUSP00000107563
Gene: ENSMUSG00000032641
AA Change: H41L

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	70	339	2.6e-12	PFAM
Pfam:7tm_1	76	324	3.5e-50	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000116515
AA Change: H41L

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)

SMART Domains

Protein: ENSMUSP00000112214
Gene: ENSMUSG00000032641
AA Change: H41L

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	70	339	2.6e-12	PFAM
Pfam:7tm_1	76	324	3.5e-50	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000165392
AA Change: H41L

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)

SMART Domains

Protein: ENSMUSP00000127876
Gene: ENSMUSG00000032641
AA Change: H41L

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	70	339	2.6e-12	PFAM
Pfam:7tm_1	76	324	3.5e-50	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000203409
AA Change: H41L

PolyPhen 2 Score 0.237 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000145128
Gene: ENSMUSG00000032641
AA Change: H41L

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	70	132	9e-5	PFAM
Pfam:7tm_1	76	135	2.6e-16	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000203762

Predicted Effect

possibly damaging
Transcript: ENSMUST00000204880
AA Change: H41L

PolyPhen 2 Score 0.810 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000144918
Gene: ENSMUSG00000032641
AA Change: H41L

Domain	Start	End	E-Value	Type
transmembrane domain	59	76	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000215088
AA Change: H96L

PolyPhen 2 Score 0.203 (Sensitivity: 0.92; Specificity: 0.88)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous mutation of this gene results in increased anxiety-like behavior. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsm4	C	T	7: 119,310,642 (GRCm39)	R510*	probably null	Het
Adamts12	A	T	15: 11,310,816 (GRCm39)	E1024D	probably benign	Het
Aff2	T	A	X: 68,911,335 (GRCm39)	D1239E	possibly damaging	Het
Agps	T	C	2: 75,683,128 (GRCm39)	V151A	probably benign	Het
Cables1	A	T	18: 12,021,821 (GRCm39)	R276S	probably damaging	Het
Cep72	A	G	13: 74,207,578 (GRCm39)	S64P	probably damaging	Het
Cmah	A	T	13: 24,614,532 (GRCm39)	D159V	probably damaging	Het
Cox6a1	C	A	5: 115,483,898 (GRCm39)		probably benign	Het
Cpxm1	T	C	2: 130,236,055 (GRCm39)	E369G	probably damaging	Het
Dnah6	A	G	6: 73,051,731 (GRCm39)	L3021P	probably benign	Het
Esyt1	T	C	10: 128,354,810 (GRCm39)	E530G	possibly damaging	Het
Fancd2	A	G	6: 113,530,713 (GRCm39)	I449V	probably benign	Het
Fbxw24	C	T	9: 109,452,701 (GRCm39)	G98D	probably damaging	Het
Folh1	T	C	7: 86,395,350 (GRCm39)	I361V	probably benign	Het
Kcnq4	A	G	4: 120,574,229 (GRCm39)	V143A	probably damaging	Het
Larp7-ps	A	G	4: 92,079,862 (GRCm39)	V42A	probably damaging	Het
Lmcd1	A	G	6: 112,287,586 (GRCm39)	I91V	probably benign	Het
Lpin3	G	T	2: 160,745,649 (GRCm39)	D651Y	probably damaging	Het
Ms4a6b	A	T	19: 11,506,871 (GRCm39)	H220L	possibly damaging	Het
Mxd4	G	A	5: 34,341,690 (GRCm39)		probably benign	Het
Nxnl2	T	C	13: 51,325,488 (GRCm39)	F44L	probably damaging	Het
Or11g2	T	A	14: 50,856,069 (GRCm39)	I130N	probably damaging	Het
Or2ag16	T	C	7: 106,351,653 (GRCm39)		probably benign	Het
Pcdhb20	A	T	18: 37,639,621 (GRCm39)	R716W	probably benign	Het
Pcx	T	A	19: 4,670,263 (GRCm39)		probably null	Het
Plekhf1	T	C	7: 37,921,221 (GRCm39)	T116A	probably benign	Het
Psmb2	G	T	4: 126,580,885 (GRCm39)	R93L	probably damaging	Het
Pstpip2	T	A	18: 77,922,916 (GRCm39)	L42*	probably null	Het
Ptpn22	A	T	3: 103,793,520 (GRCm39)	D557V	probably damaging	Het
Rbbp5	G	A	1: 132,420,339 (GRCm39)	V191I	probably benign	Het
Rgs1	T	A	1: 144,121,116 (GRCm39)	D185V	probably damaging	Het
Selenoh	A	G	2: 84,500,938 (GRCm39)		probably benign	Het
Slc6a5	C	T	7: 49,567,481 (GRCm39)	P312S	probably benign	Het
Snapc1	T	A	12: 74,011,454 (GRCm39)	M40K	probably benign	Het
Sptbn2	T	G	19: 4,796,000 (GRCm39)	Y1726*	probably null	Het
Syne2	T	C	12: 76,033,881 (GRCm39)	I3710T	probably damaging	Het
Tdrd9	G	A	12: 112,006,868 (GRCm39)	V911M	probably damaging	Het
Tex9	A	T	9: 72,388,036 (GRCm39)	D134E	possibly damaging	Het
Ttc41	G	T	10: 86,611,821 (GRCm39)	C1063F	possibly damaging	Het
Usp38	C	A	8: 81,716,647 (GRCm39)	A496S	possibly damaging	Het
Vmn2r13	T	A	5: 109,304,568 (GRCm39)	Y621F	probably damaging	Het
Vmn2r67	T	A	7: 84,785,834 (GRCm39)	M724L	probably benign	Het

Other mutations in Gpr19

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01310:Gpr19	APN	6	134,846,705 (GRCm39)	missense	probably damaging	0.99
IGL01988:Gpr19	APN	6	134,846,247 (GRCm39)	missense	probably damaging	1.00
R1530:Gpr19	UTSW	6	134,846,961 (GRCm39)	missense	probably damaging	0.97
R1548:Gpr19	UTSW	6	134,847,047 (GRCm39)	missense	possibly damaging	0.92
R1699:Gpr19	UTSW	6	134,847,192 (GRCm39)	missense	possibly damaging	0.93
R2131:Gpr19	UTSW	6	134,847,405 (GRCm39)	start codon destroyed	probably null	0.99
R5016:Gpr19	UTSW	6	134,846,880 (GRCm39)	nonsense	probably null
R6605:Gpr19	UTSW	6	134,847,398 (GRCm39)	missense	probably benign	0.02
R7080:Gpr19	UTSW	6	134,847,419 (GRCm39)	missense	probably damaging	0.99
R7746:Gpr19	UTSW	6	134,846,355 (GRCm39)	missense	probably damaging	1.00
R8014:Gpr19	UTSW	6	134,846,436 (GRCm39)	missense	probably damaging	1.00
R9176:Gpr19	UTSW	6	134,846,718 (GRCm39)	missense	probably damaging	0.99
R9408:Gpr19	UTSW	6	134,864,704 (GRCm39)	missense	unknown

Posted On

2013-11-11