Incidental Mutation 'IGL01431:Vmn1r79'
ID84105
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r79
Ensembl Gene ENSMUSG00000096735
Gene Namevomeronasal 1 receptor 79
SynonymsGm9807
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.066) question?
Stock #IGL01431
Quality Score
Status
Chromosome7
Chromosomal Location12171279-12181533 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 12176400 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 70 (S70P)
Ref Sequence ENSEMBL: ENSMUSP00000154092 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062811] [ENSMUST00000210112] [ENSMUST00000226953] [ENSMUST00000227530]
Predicted Effect possibly damaging
Transcript: ENSMUST00000062811
AA Change: S70P

PolyPhen 2 Score 0.876 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000056232
Gene: ENSMUSG00000096735
AA Change: S70P

DomainStartEndE-ValueType
Pfam:TAS2R 7 302 4.9e-9 PFAM
Pfam:7tm_1 27 292 2.8e-7 PFAM
Pfam:V1R 34 298 1.7e-35 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210112
Predicted Effect possibly damaging
Transcript: ENSMUST00000226953
AA Change: S70P

PolyPhen 2 Score 0.876 (Sensitivity: 0.83; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000227530
AA Change: S70P

PolyPhen 2 Score 0.876 (Sensitivity: 0.83; Specificity: 0.93)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930430A15Rik A T 2: 111,225,395 probably benign Het
Adamts7 A G 9: 90,207,785 I897T possibly damaging Het
Aqp2 G A 15: 99,579,420 V90M possibly damaging Het
Atf6 T C 1: 170,853,002 probably benign Het
Cdh3 T C 8: 106,547,669 Y607H probably damaging Het
Cer1 T A 4: 82,882,831 E198D probably benign Het
Dscam A G 16: 96,652,078 probably null Het
Ecel1 C T 1: 87,151,504 R484H probably damaging Het
Entpd7 C A 19: 43,729,839 H575Q probably benign Het
F11r T C 1: 171,462,909 V279A probably damaging Het
Gm17093 T A 14: 44,521,665 probably benign Het
Got1 T A 19: 43,503,049 K321* probably null Het
Gpn1 T C 5: 31,507,538 V302A probably benign Het
Hivep1 G T 13: 42,158,017 K1244N probably damaging Het
Idh3b T C 2: 130,281,897 T116A possibly damaging Het
Itgb4 C A 11: 116,006,457 probably benign Het
Mybl1 G T 1: 9,672,647 L579I probably damaging Het
Myh14 T A 7: 44,614,358 T1694S probably null Het
Mylk3 T C 8: 85,336,401 D537G probably damaging Het
Myo1d A C 11: 80,674,839 F387V probably damaging Het
Nek9 T C 12: 85,314,587 Y448C probably benign Het
Olfr1090 A T 2: 86,754,164 H191Q probably benign Het
Paxbp1 T C 16: 91,035,916 probably benign Het
Retreg2 T A 1: 75,145,105 probably null Het
Ripply3 G A 16: 94,328,543 C16Y possibly damaging Het
Robo3 G A 9: 37,419,111 probably benign Het
Rrm1 C A 7: 102,457,552 probably benign Het
Rsad2 T A 12: 26,448,667 R269S probably benign Het
Sbp A T 17: 23,945,348 probably benign Het
Schip1 A T 3: 68,617,777 Q162L probably damaging Het
Senp1 T C 15: 98,082,263 Y67C probably damaging Het
Slc25a25 C T 2: 32,419,091 R233K probably damaging Het
Smoc1 C A 12: 81,152,751 S220* probably null Het
Stab1 C A 14: 31,148,995 R1299I probably benign Het
Stk17b A G 1: 53,765,915 probably benign Het
Tmc7 T G 7: 118,552,762 D312A probably damaging Het
Zfc3h1 C A 10: 115,423,223 T1591K possibly damaging Het
Other mutations in Vmn1r79
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00592:Vmn1r79 APN 7 12177007 missense probably benign 0.05
IGL01953:Vmn1r79 APN 7 12176455 missense probably damaging 1.00
PIT4418001:Vmn1r79 UTSW 7 12176839 missense probably damaging 1.00
R0831:Vmn1r79 UTSW 7 12177063 missense probably damaging 0.98
R1791:Vmn1r79 UTSW 7 12176431 missense probably damaging 1.00
R1869:Vmn1r79 UTSW 7 12176647 missense probably benign 0.00
R3713:Vmn1r79 UTSW 7 12176212 missense possibly damaging 0.66
R4210:Vmn1r79 UTSW 7 12176488 missense possibly damaging 0.46
R4243:Vmn1r79 UTSW 7 12177044 nonsense probably null
R4244:Vmn1r79 UTSW 7 12177044 nonsense probably null
R4839:Vmn1r79 UTSW 7 12176434 missense probably benign 0.30
R5677:Vmn1r79 UTSW 7 12177001 missense possibly damaging 0.77
R6048:Vmn1r79 UTSW 7 12176521 missense probably damaging 0.99
R7388:Vmn1r79 UTSW 7 12176741 nonsense probably null
R7751:Vmn1r79 UTSW 7 12176835 nonsense probably null
R8207:Vmn1r79 UTSW 7 12176488 missense possibly damaging 0.46
Posted On2013-11-11