Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01431:Rsad2'

84120

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Rsad2

Ensembl Gene

ENSMUSG00000020641

Gene Name

radical S-adenosyl methionine domain containing 2

Synonyms

viperin, cig5, Vig1, 2510004L01Rik

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01431

Quality Score

Status

Chromosome

Chromosomal Location

26442746-26456452 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 26448667 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Serine at position 269 (R269S)

Ref Sequence

ENSEMBL: ENSMUSP00000020970 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000020970] [ENSMUST00000137792]

AlphaFold

Q8CBB9

Predicted Effect

probably benign
Transcript: ENSMUST00000020970
AA Change: R269S

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)

SMART Domains

Protein: ENSMUSP00000020970
Gene: ENSMUSG00000020641
AA Change: R269S

Domain	Start	End	E-Value	Type
low complexity region	13	28	N/A	INTRINSIC
Elp3	74	282	8.55e-12	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000137792

SMART Domains

Protein: ENSMUSP00000121791
Gene: ENSMUSG00000020641

Domain	Start	End	E-Value	Type
low complexity region	13	28	N/A	INTRINSIC
Pfam:Fer4_12	69	174	1.3e-10	PFAM
Pfam:Fer4_14	78	172	7.7e-11	PFAM
Pfam:Radical_SAM	78	178	9.5e-12	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000142732

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a null allele exhibit impaired T-helper 2 differentitation. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930430A15Rik	A	T	2: 111,225,395		probably benign	Het
Adamts7	A	G	9: 90,207,785	I897T	possibly damaging	Het
Aqp2	G	A	15: 99,579,420	V90M	possibly damaging	Het
Atf6	T	C	1: 170,853,002		probably benign	Het
Cdh3	T	C	8: 106,547,669	Y607H	probably damaging	Het
Cer1	T	A	4: 82,882,831	E198D	probably benign	Het
Dscam	A	G	16: 96,652,078		probably null	Het
Ecel1	C	T	1: 87,151,504	R484H	probably damaging	Het
Entpd7	C	A	19: 43,729,839	H575Q	probably benign	Het
F11r	T	C	1: 171,462,909	V279A	probably damaging	Het
Gm17093	T	A	14: 44,521,665		probably benign	Het
Got1	T	A	19: 43,503,049	K321*	probably null	Het
Gpn1	T	C	5: 31,507,538	V302A	probably benign	Het
Hivep1	G	T	13: 42,158,017	K1244N	probably damaging	Het
Idh3b	T	C	2: 130,281,897	T116A	possibly damaging	Het
Itgb4	C	A	11: 116,006,457		probably benign	Het
Mybl1	G	T	1: 9,672,647	L579I	probably damaging	Het
Myh14	T	A	7: 44,614,358	T1694S	probably null	Het
Mylk3	T	C	8: 85,336,401	D537G	probably damaging	Het
Myo1d	A	C	11: 80,674,839	F387V	probably damaging	Het
Nek9	T	C	12: 85,314,587	Y448C	probably benign	Het
Olfr1090	A	T	2: 86,754,164	H191Q	probably benign	Het
Paxbp1	T	C	16: 91,035,916		probably benign	Het
Retreg2	T	A	1: 75,145,105		probably null	Het
Ripply3	G	A	16: 94,328,543	C16Y	possibly damaging	Het
Robo3	G	A	9: 37,419,111		probably benign	Het
Rrm1	C	A	7: 102,457,552		probably benign	Het
Sbp	A	T	17: 23,945,348		probably benign	Het
Schip1	A	T	3: 68,617,777	Q162L	probably damaging	Het
Senp1	T	C	15: 98,082,263	Y67C	probably damaging	Het
Slc25a25	C	T	2: 32,419,091	R233K	probably damaging	Het
Smoc1	C	A	12: 81,152,751	S220*	probably null	Het
Stab1	C	A	14: 31,148,995	R1299I	probably benign	Het
Stk17b	A	G	1: 53,765,915		probably benign	Het
Tmc7	T	G	7: 118,552,762	D312A	probably damaging	Het
Vmn1r79	T	C	7: 12,176,400	S70P	possibly damaging	Het
Zfc3h1	C	A	10: 115,423,223	T1591K	possibly damaging	Het

Other mutations in Rsad2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02237:Rsad2	APN	12	26456187	missense	probably damaging	1.00
R0077:Rsad2	UTSW	12	26456377	missense	probably damaging	0.96
R0472:Rsad2	UTSW	12	26454168	missense	possibly damaging	0.87
R1368:Rsad2	UTSW	12	26447148	splice site	probably null
R1392:Rsad2	UTSW	12	26445440	missense	probably benign	0.00
R1392:Rsad2	UTSW	12	26445440	missense	probably benign	0.00
R1393:Rsad2	UTSW	12	26456377	missense	probably damaging	0.96
R1860:Rsad2	UTSW	12	26450617	missense	probably damaging	1.00
R2286:Rsad2	UTSW	12	26450676	missense	probably benign	0.20
R3430:Rsad2	UTSW	12	26456419	start codon destroyed	probably null	0.98
R5304:Rsad2	UTSW	12	26450682	missense	probably damaging	1.00
R6000:Rsad2	UTSW	12	26447151	critical splice donor site	probably null
R6052:Rsad2	UTSW	12	26450578	missense	probably benign	0.02
R6084:Rsad2	UTSW	12	26454123	missense	probably damaging	1.00
R6193:Rsad2	UTSW	12	26456187	missense	probably damaging	1.00
R7019:Rsad2	UTSW	12	26456419	start codon destroyed	possibly damaging	0.89
R7158:Rsad2	UTSW	12	26450780	splice site	probably null
R7229:Rsad2	UTSW	12	26454123	missense	probably damaging	1.00
R8330:Rsad2	UTSW	12	26456406	missense	probably benign
R9557:Rsad2	UTSW	12	26445522	missense	probably damaging	0.98

Posted On

2013-11-11