Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01432:Fbxw26'

84142

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fbxw26

Ensembl Gene

ENSMUSG00000059547

Gene Name

F-box and WD-40 domain protein 26

Synonyms

Gm5163

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01432

Quality Score

Status

Chromosome

Chromosomal Location

109717566-109746089 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 109717975 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 461 (T461S)

Ref Sequence

ENSEMBL: ENSMUSP00000071811 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071917]

AlphaFold

Q8BI58

Predicted Effect

probably benign
Transcript: ENSMUST00000071917
AA Change: T461S

PolyPhen 2 Score 0.325 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000071811
Gene: ENSMUSG00000059547
AA Change: T461S

Domain	Start	End	E-Value	Type
FBOX	5	45	2.54e-6	SMART
SCOP:d1tbga_	128	249	1e-5	SMART
Blast:WD40	137	176	4e-7	BLAST

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 74 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438A13Rik	T	A	3: 37,003,759 (GRCm38)	V3166E	possibly damaging	Het
Aldh9a1	T	C	1: 167,355,785 (GRCm38)	S191P	probably damaging	Het
Aldoart2	A	T	12: 55,565,781 (GRCm38)	I164F	probably damaging	Het
Anapc1	C	A	2: 128,633,408 (GRCm38)	A1384S	probably damaging	Het
Arid5a	T	G	1: 36,319,433 (GRCm38)	S429A	possibly damaging	Het
Asxl1	A	G	2: 153,400,205 (GRCm38)	K892E	probably benign	Het
Bpnt1	G	A	1: 185,354,021 (GRCm38)	W261*	probably null	Het
Calu	A	G	6: 29,356,553 (GRCm38)	D26G	possibly damaging	Het
Ccdc113	C	T	8: 95,538,257 (GRCm38)		probably benign	Het
Cd109	T	C	9: 78,698,123 (GRCm38)	Y1003H	probably benign	Het
Cdh9	A	G	15: 16,830,947 (GRCm38)	K290R	probably damaging	Het
Cep131	G	A	11: 120,077,009 (GRCm38)	A140V	possibly damaging	Het
Chn1	A	T	2: 73,631,752 (GRCm38)	C236S	probably damaging	Het
Cntn4	T	A	6: 106,678,334 (GRCm38)		probably benign	Het
Crispld1	A	T	1: 17,746,801 (GRCm38)	Q194L	probably benign	Het
Csmd3	A	G	15: 47,733,499 (GRCm38)	V1981A	probably damaging	Het
Cttn	A	G	7: 144,461,306 (GRCm38)	I55T	probably damaging	Het
Ddx46	G	T	13: 55,638,022 (GRCm38)		probably benign	Het
Diaph1	A	T	18: 37,897,504 (GRCm38)	I299N	unknown	Het
Dll1	A	G	17: 15,368,506 (GRCm38)	Y636H	probably damaging	Het
Eng	A	T	2: 32,669,532 (GRCm38)	Q111L	possibly damaging	Het
Exoc6	T	C	19: 37,589,876 (GRCm38)	V389A	possibly damaging	Het
Gbf1	T	C	19: 46,279,995 (GRCm38)	Y1269H	probably damaging	Het
Gm10436	T	C	12: 88,176,432 (GRCm38)	K139E	probably benign	Het
Gm5852	A	G	3: 93,727,779 (GRCm38)	Y90H	possibly damaging	Het
Gnrhr	C	T	5: 86,182,193 (GRCm38)	G323R	probably damaging	Het
Gpr155	T	A	2: 73,351,885 (GRCm38)	E661D	possibly damaging	Het
Grik4	A	T	9: 42,521,176 (GRCm38)	C842S	probably damaging	Het
Iws1	A	G	18: 32,083,466 (GRCm38)		probably benign	Het
Kif5c	A	G	2: 49,701,077 (GRCm38)	T314A	probably damaging	Het
Klhdc1	A	C	12: 69,251,977 (GRCm38)	K112T	probably damaging	Het
Kmt2a	T	C	9: 44,809,096 (GRCm38)	T3865A	unknown	Het
Lgr5	T	C	10: 115,453,092 (GRCm38)	K477R	probably damaging	Het
Ly75	A	T	2: 60,376,007 (GRCm38)	L106Q	probably damaging	Het
Mcph1	T	A	8: 18,625,639 (GRCm38)	M26K	probably damaging	Het
Mettl2	T	C	11: 105,126,522 (GRCm38)	V9A	probably benign	Het
Mgat5b	A	G	11: 116,973,376 (GRCm38)	D456G	probably benign	Het
Mstn	A	G	1: 53,066,530 (GRCm38)	T344A	possibly damaging	Het
Npr1	T	A	3: 90,463,236 (GRCm38)	I308F	possibly damaging	Het
Oasl1	G	A	5: 114,937,407 (GRCm38)	V509M	probably benign	Het
Obscn	T	C	11: 59,033,757 (GRCm38)	M5727V	probably benign	Het
Olfr1219	T	A	2: 89,074,201 (GRCm38)	I297F	probably benign	Het
Olfr262	A	G	19: 12,241,527 (GRCm38)	S45P	probably damaging	Het
Olfr710	T	C	7: 106,944,541 (GRCm38)	I153M	possibly damaging	Het
Olfr726	T	A	14: 50,083,947 (GRCm38)	T245S	probably benign	Het
Pcgf1	T	C	6: 83,078,417 (GRCm38)	I11T	possibly damaging	Het
Phactr3	T	C	2: 178,283,100 (GRCm38)	V276A	probably benign	Het
Pla2g6	A	T	15: 79,317,968 (GRCm38)	M1K	probably null	Het
Plec	T	C	15: 76,190,528 (GRCm38)	E413G	probably damaging	Het
Plxna2	G	T	1: 194,644,318 (GRCm38)	A187S	possibly damaging	Het
Polq	A	T	16: 37,071,822 (GRCm38)		probably benign	Het
Prss39	A	G	1: 34,502,135 (GRCm38)	D240G	probably benign	Het
Ptpn12	A	T	5: 20,998,555 (GRCm38)	Y408*	probably null	Het
Ptprt	A	G	2: 162,268,079 (GRCm38)		probably benign	Het
Rnf6	A	T	5: 146,216,121 (GRCm38)	S95T	possibly damaging	Het
Ryr2	T	C	13: 11,851,204 (GRCm38)	S287G	possibly damaging	Het
Samd4b	A	G	7: 28,414,066 (GRCm38)	F158S	possibly damaging	Het
Slco1a5	T	A	6: 142,236,286 (GRCm38)	I571L	possibly damaging	Het
Smchd1	T	C	17: 71,431,290 (GRCm38)	T527A	probably damaging	Het
Smg9	T	C	7: 24,421,266 (GRCm38)		probably null	Het
Snx25	A	G	8: 46,105,160 (GRCm38)	L270P	probably damaging	Het
Ssh1	G	T	5: 113,958,822 (GRCm38)	T165N	probably benign	Het
Stk24	T	A	14: 121,302,806 (GRCm38)	E127V	probably damaging	Het
Suco	A	G	1: 161,834,120 (GRCm38)	V914A	probably damaging	Het
Tbcd	T	A	11: 121,475,680 (GRCm38)		probably benign	Het
Tbcel	A	T	9: 42,444,521 (GRCm38)	L114Q	possibly damaging	Het
Trpm1	A	G	7: 64,235,019 (GRCm38)	D816G	probably benign	Het
Uhrf1	G	A	17: 56,318,250 (GRCm38)	V566M	probably damaging	Het
Ulk4	T	A	9: 121,266,301 (GRCm38)	E95D	probably damaging	Het
Vmn1r40	T	C	6: 89,714,219 (GRCm38)	M6T	probably benign	Het
Vmn2r59	C	T	7: 42,012,559 (GRCm38)	V611I	possibly damaging	Het
Vwde	G	T	6: 13,193,240 (GRCm38)	H367N	probably benign	Het
Wdr66	A	G	5: 123,279,952 (GRCm38)	I81M	possibly damaging	Het
Xpo6	A	G	7: 126,124,381 (GRCm38)	V585A	probably benign	Het

Other mutations in Fbxw26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00589:Fbxw26	APN	9	109,717,948 (GRCm38)	utr 3 prime	probably benign
IGL01072:Fbxw26	APN	9	109,723,837 (GRCm38)	missense	probably damaging	1.00
IGL01151:Fbxw26	APN	9	109,721,780 (GRCm38)	missense	possibly damaging	0.50
IGL01394:Fbxw26	APN	9	109,717,989 (GRCm38)	missense	probably benign	0.00
IGL02559:Fbxw26	APN	9	109,722,164 (GRCm38)	missense	probably benign	0.34
IGL02981:Fbxw26	APN	9	109,744,794 (GRCm38)	missense	probably benign	0.09
IGL03370:Fbxw26	APN	9	109,746,019 (GRCm38)	missense	probably damaging	1.00
R0023:Fbxw26	UTSW	9	109,718,011 (GRCm38)	missense	probably benign	0.01
R0087:Fbxw26	UTSW	9	109,724,938 (GRCm38)	missense	probably benign
R0369:Fbxw26	UTSW	9	109,723,712 (GRCm38)	critical splice donor site	probably null
R0446:Fbxw26	UTSW	9	109,743,720 (GRCm38)	missense	probably benign	0.03
R1844:Fbxw26	UTSW	9	109,724,878 (GRCm38)	missense	probably benign	0.42
R1891:Fbxw26	UTSW	9	109,722,164 (GRCm38)	missense	probably benign	0.34
R2042:Fbxw26	UTSW	9	109,732,704 (GRCm38)	missense	probably damaging	1.00
R3615:Fbxw26	UTSW	9	109,743,760 (GRCm38)	nonsense	probably null
R3616:Fbxw26	UTSW	9	109,743,760 (GRCm38)	nonsense	probably null
R4659:Fbxw26	UTSW	9	109,744,871 (GRCm38)	missense	probably damaging	0.97
R4785:Fbxw26	UTSW	9	109,724,800 (GRCm38)	missense	possibly damaging	0.50
R4898:Fbxw26	UTSW	9	109,717,969 (GRCm38)	missense	possibly damaging	0.95
R5791:Fbxw26	UTSW	9	109,745,153 (GRCm38)	missense	probably damaging	1.00
R5818:Fbxw26	UTSW	9	109,732,566 (GRCm38)	missense	probably benign
R5921:Fbxw26	UTSW	9	109,746,018 (GRCm38)	missense	probably damaging	1.00
R5983:Fbxw26	UTSW	9	109,717,965 (GRCm38)	missense	possibly damaging	0.49
R6145:Fbxw26	UTSW	9	109,732,623 (GRCm38)	missense	probably benign	0.09
R6209:Fbxw26	UTSW	9	109,717,965 (GRCm38)	missense	possibly damaging	0.49
R6412:Fbxw26	UTSW	9	109,732,647 (GRCm38)	missense	probably damaging	0.97
R6842:Fbxw26	UTSW	9	109,724,920 (GRCm38)	missense	probably damaging	1.00
R7228:Fbxw26	UTSW	9	109,724,944 (GRCm38)	missense	possibly damaging	0.93
R7451:Fbxw26	UTSW	9	109,732,623 (GRCm38)	missense	probably benign	0.03
R7467:Fbxw26	UTSW	9	109,732,697 (GRCm38)	missense	probably benign	0.00
R8397:Fbxw26	UTSW	9	109,732,647 (GRCm38)	missense	probably damaging	0.99
R8912:Fbxw26	UTSW	9	109,732,649 (GRCm38)	missense	probably damaging	1.00
R9284:Fbxw26	UTSW	9	109,721,894 (GRCm38)	intron	probably benign
R9479:Fbxw26	UTSW	9	109,732,557 (GRCm38)	missense	probably damaging	0.99
R9694:Fbxw26	UTSW	9	109,746,067 (GRCm38)	start gained	probably benign
X0020:Fbxw26	UTSW	9	109,732,632 (GRCm38)	missense	probably damaging	1.00

Posted On

2013-11-11