Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00836:Zfp974'

8426

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp974

Ensembl Gene

ENSMUSG00000070709

Gene Name

zinc finger protein 974

Synonyms

1700049G17Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

IGL00836

Quality Score

Status

Chromosome

Chromosomal Location

27606817-27628885 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 27610315 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 470 (E470G)

Ref Sequence

ENSEMBL: ENSMUSP00000096238 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098639] [ENSMUST00000129341]

AlphaFold

Q3UVF6

Predicted Effect

possibly damaging
Transcript: ENSMUST00000098639
AA Change: E470G

PolyPhen 2 Score 0.831 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000096238
Gene: ENSMUSG00000070709
AA Change: E470G

Domain	Start	End	E-Value	Type
ZnF_C2H2	99	121	8.81e-2	SMART
ZnF_C2H2	127	149	1.82e-3	SMART
ZnF_C2H2	155	177	3.11e-2	SMART
ZnF_C2H2	201	223	2.15e-5	SMART
ZnF_C2H2	229	251	1.18e-2	SMART
ZnF_C2H2	257	279	1.47e-3	SMART
ZnF_C2H2	285	307	1.79e-2	SMART
ZnF_C2H2	313	335	2.24e-3	SMART
ZnF_C2H2	341	363	9.73e-4	SMART
ZnF_C2H2	369	391	7.26e-3	SMART
ZnF_C2H2	397	419	6.42e-4	SMART
ZnF_C2H2	425	447	3.63e-3	SMART
ZnF_C2H2	453	475	1.28e-3	SMART
ZnF_C2H2	481	503	1.26e-2	SMART
ZnF_C2H2	509	531	1.38e-3	SMART
ZnF_C2H2	537	559	3.83e-2	SMART
ZnF_C2H2	565	587	1.95e-3	SMART
ZnF_C2H2	593	615	4.61e-5	SMART
ZnF_C2H2	621	643	1.95e-3	SMART
ZnF_C2H2	649	671	1.03e-2	SMART
ZnF_C2H2	677	699	5.5e-3	SMART
ZnF_C2H2	705	727	2.37e2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000129341

SMART Domains

Protein: ENSMUSP00000115940
Gene: ENSMUSG00000070709

Domain	Start	End	E-Value	Type
KRAB	14	75	7.5e-37	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 22 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ccdc18	G	A	5: 108,328,391 (GRCm39)	S697N	probably benign	Het
Cyp2c29	A	G	19: 39,313,434 (GRCm39)	D310G	probably damaging	Het
Cyp4f13	G	A	17: 33,160,138 (GRCm39)	H79Y	probably benign	Het
Dtna	T	C	18: 23,730,545 (GRCm39)	S311P	probably benign	Het
Dynlrb2	A	G	8: 117,241,572 (GRCm39)	T39A	probably benign	Het
Erc2	T	C	14: 27,762,478 (GRCm39)	I747T	probably damaging	Het
Herc6	G	A	6: 57,596,534 (GRCm39)	M491I	probably damaging	Het
Klra3	A	T	6: 130,304,107 (GRCm39)	I195N	probably benign	Het
Lama3	A	G	18: 12,605,285 (GRCm39)	I1080V	probably benign	Het
Pls1	A	G	9: 95,643,475 (GRCm39)	V508A	possibly damaging	Het
Prdm10	C	A	9: 31,241,165 (GRCm39)		probably benign	Het
Rnase1	T	A	14: 51,383,003 (GRCm39)	Y117F	probably benign	Het
S100pbp	A	T	4: 129,075,901 (GRCm39)	N141K	possibly damaging	Het
Sin3a	T	A	9: 57,014,629 (GRCm39)		probably null	Het
Slc2a2	G	A	3: 28,772,890 (GRCm39)	A228T	possibly damaging	Het
Smurf2	A	G	11: 106,743,462 (GRCm39)	Y182H	probably benign	Het
Snx2	T	A	18: 53,349,472 (GRCm39)	M411K	possibly damaging	Het
Stx17	T	C	4: 48,158,955 (GRCm39)	S90P	possibly damaging	Het
Stxbp5l	A	T	16: 37,028,462 (GRCm39)	S534T	possibly damaging	Het
Tacc2	A	G	7: 130,360,898 (GRCm39)	D2730G	probably damaging	Het
Timm8b	A	G	9: 50,516,294 (GRCm39)	D49G	possibly damaging	Het
Ufd1	G	T	16: 18,646,468 (GRCm39)		probably benign	Het

Other mutations in Zfp974

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01805:Zfp974	APN	7	27,611,689 (GRCm39)	splice site	probably benign
IGL02313:Zfp974	APN	7	27,611,678 (GRCm39)	missense	possibly damaging	0.53
IGL02449:Zfp974	APN	7	27,611,152 (GRCm39)	missense	probably benign
R0362:Zfp974	UTSW	7	27,626,819 (GRCm39)	splice site	probably benign
R0372:Zfp974	UTSW	7	27,620,120 (GRCm39)	critical splice donor site	probably null
R0379:Zfp974	UTSW	7	27,610,357 (GRCm39)	missense	probably damaging	0.98
R0699:Zfp974	UTSW	7	27,611,416 (GRCm39)	missense	possibly damaging	0.56
R0791:Zfp974	UTSW	7	27,609,510 (GRCm39)	nonsense	probably null
R1411:Zfp974	UTSW	7	27,610,634 (GRCm39)	missense	probably benign	0.00
R1567:Zfp974	UTSW	7	27,610,148 (GRCm39)	missense	probably damaging	0.99
R1747:Zfp974	UTSW	7	27,610,506 (GRCm39)	missense	possibly damaging	0.61
R1837:Zfp974	UTSW	7	27,609,781 (GRCm39)	missense	possibly damaging	0.93
R1838:Zfp974	UTSW	7	27,609,781 (GRCm39)	missense	possibly damaging	0.93
R1839:Zfp974	UTSW	7	27,609,781 (GRCm39)	missense	possibly damaging	0.93
R2311:Zfp974	UTSW	7	27,609,866 (GRCm39)	missense	possibly damaging	0.73
R4006:Zfp974	UTSW	7	27,611,677 (GRCm39)	missense	possibly damaging	0.86
R4303:Zfp974	UTSW	7	27,609,657 (GRCm39)	missense	possibly damaging	0.85
R4541:Zfp974	UTSW	7	27,625,829 (GRCm39)	missense	probably damaging	0.99
R4771:Zfp974	UTSW	7	27,625,733 (GRCm39)	missense	probably damaging	0.96
R4889:Zfp974	UTSW	7	27,610,244 (GRCm39)	missense	possibly damaging	0.86
R5332:Zfp974	UTSW	7	27,625,715 (GRCm39)	missense	probably benign	0.01
R5537:Zfp974	UTSW	7	27,611,671 (GRCm39)	critical splice acceptor site	probably benign
R5906:Zfp974	UTSW	7	27,610,230 (GRCm39)	missense	possibly damaging	0.72
R5908:Zfp974	UTSW	7	27,610,382 (GRCm39)	missense	probably benign	0.01
R6419:Zfp974	UTSW	7	27,610,940 (GRCm39)	missense	possibly damaging	0.72
R6654:Zfp974	UTSW	7	27,625,828 (GRCm39)	missense	probably damaging	1.00
R6731:Zfp974	UTSW	7	27,611,074 (GRCm39)	missense	possibly damaging	0.93
R7162:Zfp974	UTSW	7	27,610,944 (GRCm39)	missense	possibly damaging	0.71
R7316:Zfp974	UTSW	7	27,609,863 (GRCm39)	missense	possibly damaging	0.93
R7484:Zfp974	UTSW	7	27,611,559 (GRCm39)	missense	possibly damaging	0.72
R7663:Zfp974	UTSW	7	27,611,110 (GRCm39)	missense	possibly damaging	0.74
R7664:Zfp974	UTSW	7	27,610,137 (GRCm39)	missense	possibly damaging	0.86
R8052:Zfp974	UTSW	7	27,610,697 (GRCm39)	missense	probably damaging	1.00
R8698:Zfp974	UTSW	7	27,610,361 (GRCm39)	missense	possibly damaging	0.90
R8700:Zfp974	UTSW	7	27,609,472 (GRCm39)	missense	possibly damaging	0.86
R8938:Zfp974	UTSW	7	27,610,311 (GRCm39)	missense	possibly damaging	0.74
R8972:Zfp974	UTSW	7	27,610,589 (GRCm39)	missense	probably benign	0.06
R9212:Zfp974	UTSW	7	27,610,052 (GRCm39)	missense	possibly damaging	0.86
R9236:Zfp974	UTSW	7	27,610,342 (GRCm39)	missense	possibly damaging	0.51
R9335:Zfp974	UTSW	7	27,611,476 (GRCm39)	missense	probably benign	0.02
R9436:Zfp974	UTSW	7	27,611,094 (GRCm39)	missense	probably benign	0.24
R9740:Zfp974	UTSW	7	27,610,025 (GRCm39)	missense	probably damaging	1.00

Posted On

2012-12-06