Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01434:Tmem41b'

84293

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem41b

Ensembl Gene

ENSMUSG00000047554

Gene Name

transmembrane protein 41B

Synonyms

1500031M19Rik, 1500015G02Rik, D7Ertd70e, D7Ertd743e

Accession Numbers

Essential gene?

Probably essential (E-score: 0.940) question?

Stock #

IGL01434

Quality Score

Status

Chromosome

Chromosomal Location

109571394-109586136 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to G at 109577909 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000123138 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094097] [ENSMUST00000118429] [ENSMUST00000119929] [ENSMUST00000124821] [ENSMUST00000135565] [ENSMUST00000154831]

AlphaFold

Q8K1A5

Predicted Effect

probably benign
Transcript: ENSMUST00000094097

SMART Domains

Protein: ENSMUSP00000091641
Gene: ENSMUSG00000047554

Domain	Start	End	E-Value	Type
transmembrane domain	53	72	N/A	INTRINSIC
Blast:uDENN	81	113	2e-13	BLAST
Pfam:SNARE_assoc	129	250	2.5e-26	PFAM
transmembrane domain	260	282	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000118429

SMART Domains

Protein: ENSMUSP00000112574
Gene: ENSMUSG00000047554

Domain	Start	End	E-Value	Type
transmembrane domain	53	72	N/A	INTRINSIC
Blast:uDENN	81	113	2e-13	BLAST
Pfam:SNARE_assoc	129	250	1.2e-24	PFAM
transmembrane domain	260	282	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000119929

SMART Domains

Protein: ENSMUSP00000113215
Gene: ENSMUSG00000047554

Domain	Start	End	E-Value	Type
Blast:uDENN	13	48	4e-14	BLAST
Pfam:SNARE_assoc	62	183	6e-27	PFAM
transmembrane domain	193	215	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000124821

SMART Domains

Protein: ENSMUSP00000119520
Gene: ENSMUSG00000047554

Domain	Start	End	E-Value	Type
transmembrane domain	53	72	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000125703

Predicted Effect

probably benign
Transcript: ENSMUST00000135565

SMART Domains

Protein: ENSMUSP00000121078
Gene: ENSMUSG00000047554

Domain	Start	End	E-Value	Type
transmembrane domain	53	72	N/A	INTRINSIC
Blast:uDENN	81	113	7e-15	BLAST

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000151587

Predicted Effect

probably benign
Transcript: ENSMUST00000154831

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsm3	A	G	7: 119,380,297 (GRCm39)		probably benign	Het
Adcy7	A	G	8: 89,051,472 (GRCm39)	N864S	probably damaging	Het
Anapc7	A	G	5: 122,576,279 (GRCm39)	D302G	probably benign	Het
Atm	A	T	9: 53,419,107 (GRCm39)	C782S	probably benign	Het
Bicdl1	G	A	5: 115,808,215 (GRCm39)	Q37*	probably null	Het
Cabin1	T	C	10: 75,561,420 (GRCm39)	D1027G	possibly damaging	Het
Cbl	T	C	9: 44,075,503 (GRCm39)	I364V	probably damaging	Het
Ccer1	T	C	10: 97,529,459 (GRCm39)	S41P	unknown	Het
Cenpf	G	A	1: 189,390,065 (GRCm39)	Q1256*	probably null	Het
Copa	T	A	1: 171,947,128 (GRCm39)	I1093N	probably benign	Het
Cped1	C	T	6: 22,017,004 (GRCm39)	L118F	probably damaging	Het
Cplane2	T	C	4: 140,945,964 (GRCm39)	V169A	probably benign	Het
Cstdc4	T	A	16: 36,006,777 (GRCm39)	V37E	probably benign	Het
Dner	T	C	1: 84,361,731 (GRCm39)	H626R	probably benign	Het
Ears2	G	A	7: 121,662,311 (GRCm39)		probably benign	Het
Eif3c	A	G	7: 126,155,582 (GRCm39)	I562T	probably damaging	Het
Eml6	T	C	11: 29,769,090 (GRCm39)	Y685C	probably damaging	Het
Garin1b	T	C	6: 29,320,700 (GRCm39)	V108A	probably damaging	Het
Gpt	A	G	15: 76,582,982 (GRCm39)	K321E	probably damaging	Het
Hspd1	C	T	1: 55,120,285 (GRCm39)	G306R	probably damaging	Het
Kmt2c	T	C	5: 25,614,306 (GRCm39)	Y138C	probably damaging	Het
Lhcgr	A	G	17: 89,049,865 (GRCm39)	Y554H	probably damaging	Het
Nell1	A	T	7: 50,350,956 (GRCm39)	K534N	probably benign	Het
Nob1	A	G	8: 108,151,360 (GRCm39)		probably benign	Het
Or13a17	G	A	7: 140,271,531 (GRCm39)	A238T	probably damaging	Het
Phf12	C	T	11: 77,914,385 (GRCm39)	P60L	probably damaging	Het
Prkdc	A	G	16: 15,531,451 (GRCm39)	E1358G	probably benign	Het
Rimbp3	A	G	16: 17,029,566 (GRCm39)	T997A	probably benign	Het
Slc9a9	T	A	9: 94,901,247 (GRCm39)	N393K	possibly damaging	Het
Sohlh2	T	C	3: 55,102,582 (GRCm39)	S206P	probably damaging	Het
Stard10	G	A	7: 100,971,187 (GRCm39)	V125M	probably benign	Het
Tff2	G	T	17: 31,362,240 (GRCm39)		probably null	Het
Tha1	T	C	11: 117,759,425 (GRCm39)	T355A	probably benign	Het
Tmem120a	G	T	5: 135,765,864 (GRCm39)	F127L	possibly damaging	Het
Tonsl	T	C	15: 76,515,302 (GRCm39)	D1028G	probably benign	Het

Other mutations in Tmem41b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02174:Tmem41b	APN	7	109,578,003 (GRCm39)	missense	possibly damaging	0.89
IGL02232:Tmem41b	APN	7	109,577,960 (GRCm39)	missense	probably damaging	0.98
IGL02523:Tmem41b	APN	7	109,581,935 (GRCm39)	missense	probably damaging	1.00
R0610:Tmem41b	UTSW	7	109,580,292 (GRCm39)	missense	probably damaging	0.99
R0610:Tmem41b	UTSW	7	109,580,290 (GRCm39)	missense	probably benign	0.02
R0840:Tmem41b	UTSW	7	109,580,256 (GRCm39)	missense	probably damaging	1.00
R4610:Tmem41b	UTSW	7	109,573,941 (GRCm39)	unclassified	probably benign
R5502:Tmem41b	UTSW	7	109,581,970 (GRCm39)	nonsense	probably null
R5650:Tmem41b	UTSW	7	109,574,072 (GRCm39)	missense	probably damaging	1.00
R5769:Tmem41b	UTSW	7	109,577,945 (GRCm39)	missense	possibly damaging	0.69

Posted On

2013-11-11