Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01443:Lypd3'

84327

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lypd3

Ensembl Gene

ENSMUSG00000057454

Gene Name

Ly6/Plaur domain containing 3

Synonyms

2310061G07Rik, C4.4A

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.138) question?

Stock #

IGL01443

Quality Score

Status

Chromosome

Chromosomal Location

24335995-24340543 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 24336063 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Arginine at position 17 (G17R)

Ref Sequence

ENSEMBL: ENSMUSP00000079543 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080718]

AlphaFold

Q91YK8

Predicted Effect

probably benign
Transcript: ENSMUST00000080718
AA Change: G17R

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000079543
Gene: ENSMUSG00000057454
AA Change: G17R

Domain	Start	End	E-Value	Type
signal peptide	1	32	N/A	INTRINSIC
LU	33	128	7.26e-26	SMART
Pfam:UPAR_LY6	142	224	1.3e-16	PFAM
low complexity region	234	255	N/A	INTRINSIC
low complexity region	258	278	N/A	INTRINSIC
low complexity region	303	320	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000180699

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous null mice show no overt epidermal phenotype and have normal squamous epithelia morphology but are lighter and leaner than controls. Males display delayed wound healing whereas females show reduced food intake and a lower incidence of invasive lesions in a BBN-induced bladder cancer model. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts2	A	G	11: 50,694,690 (GRCm39)	E1159G	possibly damaging	Het
Adgrl3	A	G	5: 81,613,134 (GRCm39)	Y189C	probably damaging	Het
AW554918	G	A	18: 25,478,012 (GRCm39)	G446R	probably damaging	Het
Baiap3	A	G	17: 25,464,121 (GRCm39)	F884S	possibly damaging	Het
Cd101	T	C	3: 100,910,887 (GRCm39)	T924A	probably benign	Het
Cdk12	T	A	11: 98,136,295 (GRCm39)	V1183E	unknown	Het
Clcc1	T	C	3: 108,578,219 (GRCm39)	M240T	probably benign	Het
Dnmbp	C	A	19: 43,891,309 (GRCm39)	A153S	probably damaging	Het
Dus4l	T	C	12: 31,702,409 (GRCm39)		probably benign	Het
Dyrk1a	A	G	16: 94,485,943 (GRCm39)	E430G	probably benign	Het
Erc1	T	C	6: 119,801,432 (GRCm39)	K195R	probably damaging	Het
Evpl	T	C	11: 116,113,280 (GRCm39)	E1470G	probably damaging	Het
Extl3	A	T	14: 65,314,919 (GRCm39)	S88T	probably damaging	Het
Fam135b	A	T	15: 71,335,213 (GRCm39)	H660Q	probably benign	Het
Fat1	G	A	8: 45,493,613 (GRCm39)	G3920S	probably damaging	Het
Fbxo38	A	G	18: 62,666,741 (GRCm39)	V144A	probably damaging	Het
Grwd1	C	T	7: 45,479,834 (GRCm39)		probably null	Het
Hdlbp	T	C	1: 93,358,796 (GRCm39)	T252A	probably damaging	Het
Igkv3-1	A	G	6: 70,681,088 (GRCm39)	S96G	possibly damaging	Het
Igkv4-68	G	T	6: 69,281,921 (GRCm39)	F83L	probably damaging	Het
Klhl31	T	C	9: 77,557,542 (GRCm39)	V86A	possibly damaging	Het
Manba	T	A	3: 135,250,589 (GRCm39)	D405E	probably damaging	Het
Map3k19	A	G	1: 127,766,244 (GRCm39)	S227P	probably benign	Het
Nras	T	A	3: 102,969,751 (GRCm39)	C118S	probably benign	Het
Or52n20	A	G	7: 104,320,278 (GRCm39)	D123G	probably damaging	Het
Pde8a	T	C	7: 80,973,929 (GRCm39)	F629L	probably damaging	Het
Phtf2	A	G	5: 20,987,265 (GRCm39)		probably benign	Het
Pik3c2a	A	T	7: 116,017,429 (GRCm39)	F109L	probably benign	Het
Plod3	G	A	5: 137,019,075 (GRCm39)	R320H	probably benign	Het
Ppib	T	C	9: 65,972,879 (GRCm39)	F152L	probably damaging	Het
Rbm19	T	C	5: 120,281,503 (GRCm39)		probably benign	Het
Rgs12	T	A	5: 35,132,563 (GRCm39)	S628R	probably benign	Het
Ripk1	A	G	13: 34,199,251 (GRCm39)	D201G	probably damaging	Het
Speer4c2	A	G	5: 15,857,642 (GRCm39)	*212Q	probably null	Het
St14	G	T	9: 31,011,489 (GRCm39)	S434*	probably null	Het
Tbc1d9	A	G	8: 83,966,560 (GRCm39)	D387G	probably damaging	Het
Trio	A	G	15: 27,838,861 (GRCm39)		probably benign	Het
Ttn	G	A	2: 76,544,215 (GRCm39)	R32924C	probably damaging	Het
Vmn1r181	T	C	7: 23,684,006 (GRCm39)	V157A	possibly damaging	Het
Zfp473	C	T	7: 44,388,987 (GRCm39)	D45N	probably damaging	Het

Other mutations in Lypd3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01129:Lypd3	APN	7	24,340,018 (GRCm39)	missense	probably benign	0.00
R0200:Lypd3	UTSW	7	24,339,656 (GRCm39)	missense	probably damaging	1.00
R0726:Lypd3	UTSW	7	24,337,969 (GRCm39)	nonsense	probably null
R1706:Lypd3	UTSW	7	24,339,755 (GRCm39)	missense	probably benign	0.00
R5714:Lypd3	UTSW	7	24,338,494 (GRCm39)	missense	possibly damaging	0.86
R5771:Lypd3	UTSW	7	24,339,787 (GRCm39)	missense	probably benign
R6137:Lypd3	UTSW	7	24,339,919 (GRCm39)	missense	probably benign	0.00
R6908:Lypd3	UTSW	7	24,337,858 (GRCm39)	missense	probably damaging	1.00
R6932:Lypd3	UTSW	7	24,337,858 (GRCm39)	missense	probably damaging	1.00
R6935:Lypd3	UTSW	7	24,337,858 (GRCm39)	missense	probably damaging	1.00
R7632:Lypd3	UTSW	7	24,337,865 (GRCm39)	missense	possibly damaging	0.60
R8769:Lypd3	UTSW	7	24,337,932 (GRCm39)	missense	probably damaging	0.99
R9663:Lypd3	UTSW	7	24,338,349 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-11-11