Incidental Mutation 'IGL00850:Prr29'
ID8434
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prr29
Ensembl Gene ENSMUSG00000009210
Gene Nameproline rich 29
Synonyms2310007L24Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00850
Quality Score
Status
Chromosome11
Chromosomal Location106365472-106377558 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 106375207 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Lysine at position 32 (T32K)
Ref Sequence ENSEMBL: ENSMUSP00000139960 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000001055] [ENSMUST00000009354] [ENSMUST00000106813] [ENSMUST00000106816] [ENSMUST00000185986] [ENSMUST00000188561] [ENSMUST00000190268] [ENSMUST00000190795]
Predicted Effect probably benign
Transcript: ENSMUST00000001055
SMART Domains Protein: ENSMUSP00000001055
Gene: ENSMUSG00000001029

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ICAM_N 22 114 8.6e-45 PFAM
Blast:IG_like 119 215 2e-36 BLAST
transmembrane domain 224 246 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000009354
SMART Domains Protein: ENSMUSP00000009354
Gene: ENSMUSG00000009210

DomainStartEndE-ValueType
Pfam:DUF4587 1 60 9.4e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106813
SMART Domains Protein: ENSMUSP00000102426
Gene: ENSMUSG00000001029

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ICAM_N 22 114 2.8e-45 PFAM
Blast:IG_like 119 161 9e-11 BLAST
Predicted Effect possibly damaging
Transcript: ENSMUST00000106816
AA Change: T32K

PolyPhen 2 Score 0.759 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000102429
Gene: ENSMUSG00000009210
AA Change: T32K

DomainStartEndE-ValueType
Pfam:DUF4587 39 110 1.5e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000173795
SMART Domains Protein: ENSMUSP00000133315
Gene: ENSMUSG00000001029

DomainStartEndE-ValueType
Pfam:ICAM_N 1 50 2.2e-21 PFAM
Blast:IG_like 55 151 2e-37 BLAST
Predicted Effect possibly damaging
Transcript: ENSMUST00000185986
AA Change: T25K

PolyPhen 2 Score 0.759 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000140365
Gene: ENSMUSG00000009210
AA Change: T25K

DomainStartEndE-ValueType
Pfam:DUF4587 32 103 1.5e-22 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000188561
AA Change: T32K

PolyPhen 2 Score 0.819 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000140194
Gene: ENSMUSG00000009210
AA Change: T32K

DomainStartEndE-ValueType
Pfam:DUF4587 39 101 1.5e-18 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000190268
AA Change: T32K

PolyPhen 2 Score 0.928 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000139960
Gene: ENSMUSG00000009210
AA Change: T32K

DomainStartEndE-ValueType
Pfam:DUF4587 39 110 2.8e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000190795
SMART Domains Protein: ENSMUSP00000140541
Gene: ENSMUSG00000009210

DomainStartEndE-ValueType
Pfam:DUF4587 1 60 9.4e-20 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cand1 C A 10: 119,211,135 V817L probably benign Het
Cdc16 T G 8: 13,767,575 Y295* probably null Het
Cdk12 T A 11: 98,222,665 N758K unknown Het
Cep295 A G 9: 15,322,852 L2216S probably benign Het
Chpf2 A G 5: 24,592,261 E735G probably damaging Het
Chrdl2 A G 7: 100,034,641 T432A probably damaging Het
Cyp4a12b T A 4: 115,438,049 probably null Het
D130043K22Rik T G 13: 24,867,174 D464E probably damaging Het
Dst G T 1: 34,306,624 A7622S probably damaging Het
Fdx1 A T 9: 51,948,649 I127N probably damaging Het
Fem1a A G 17: 56,258,355 I483V possibly damaging Het
Gcc2 C A 10: 58,258,248 D51E probably benign Het
Glrb A G 3: 80,861,781 S178P probably damaging Het
Inpp4b A G 8: 81,856,750 Q161R probably damaging Het
Lrrc45 T C 11: 120,720,610 probably benign Het
Myh3 T C 11: 67,090,855 Y757H probably damaging Het
Myo1h A C 5: 114,315,071 probably benign Het
Nudt13 T A 14: 20,306,350 S114R probably damaging Het
Omg T C 11: 79,502,714 N106S possibly damaging Het
Pbrm1 T C 14: 31,087,619 V1163A probably damaging Het
Pi4k2b T A 5: 52,760,950 Y350* probably null Het
Psd4 C T 2: 24,394,286 A54V probably benign Het
Scd3 A G 19: 44,235,808 H160R probably damaging Het
Shroom3 T C 5: 92,951,065 L1387P probably damaging Het
Stk35 A G 2: 129,801,992 T299A probably damaging Het
Thsd7b G A 1: 130,165,077 S1238N probably benign Het
Utp11 T C 4: 124,682,457 K131R probably benign Het
Vps50 C T 6: 3,532,177 Q227* probably null Het
Zan T C 5: 137,464,113 T935A unknown Het
Other mutations in Prr29
AlleleSourceChrCoordTypePredicted EffectPPH Score
Partisans UTSW 11 106376259 missense probably damaging 0.96
R0027:Prr29 UTSW 11 106376276 missense possibly damaging 0.81
R0193:Prr29 UTSW 11 106376896 missense probably damaging 1.00
R1707:Prr29 UTSW 11 106376683 missense probably damaging 0.99
R1861:Prr29 UTSW 11 106375438 missense probably damaging 1.00
R3125:Prr29 UTSW 11 106374885 missense probably benign 0.00
R4664:Prr29 UTSW 11 106376333 missense probably damaging 1.00
R4998:Prr29 UTSW 11 106376953 missense probably benign 0.01
R6244:Prr29 UTSW 11 106376632 intron probably null
R6492:Prr29 UTSW 11 106375236 missense probably damaging 1.00
R7069:Prr29 UTSW 11 106376259 missense probably damaging 0.96
R7254:Prr29 UTSW 11 106374858 start codon destroyed probably damaging 0.97
R7611:Prr29 UTSW 11 106376332 missense probably damaging 1.00
R8023:Prr29 UTSW 11 106376273 missense probably benign 0.45
R8039:Prr29 UTSW 11 106376912 missense probably benign 0.10
Z1176:Prr29 UTSW 11 106376941 missense possibly damaging 0.56
Posted On2012-12-06