Incidental Mutation 'IGL01444:Ang'
ID 84344
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ang
Ensembl Gene ENSMUSG00000072115
Gene Name angiogenin, ribonuclease, RNase A family, 5
Synonyms Ang1, Rnase5a
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.132) question?
Stock # IGL01444
Quality Score
Status
Chromosome 14
Chromosomal Location 51091150-51102009 bp(+) (GRCm38)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 51101667 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 88 (Y88*)
Ref Sequence ENSEMBL: ENSMUSP00000132084 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022428] [ENSMUST00000069011] [ENSMUST00000169895] [ENSMUST00000171688]
AlphaFold P21570
Predicted Effect probably benign
Transcript: ENSMUST00000022428
SMART Domains Protein: ENSMUSP00000022428
Gene: ENSMUSG00000021876

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
RNAse_Pc 30 148 8.54e-60 SMART
Predicted Effect probably null
Transcript: ENSMUST00000069011
AA Change: Y88*
SMART Domains Protein: ENSMUSP00000067434
Gene: ENSMUSG00000072115
AA Change: Y88*

DomainStartEndE-ValueType
low complexity region 5 21 N/A INTRINSIC
RNAse_Pc 26 142 6.52e-65 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000169895
SMART Domains Protein: ENSMUSP00000127274
Gene: ENSMUSG00000021876

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
RNAse_Pc 30 148 8.54e-60 SMART
Predicted Effect probably null
Transcript: ENSMUST00000171688
AA Change: Y88*
SMART Domains Protein: ENSMUSP00000132084
Gene: ENSMUSG00000072115
AA Change: Y88*

DomainStartEndE-ValueType
low complexity region 5 21 N/A INTRINSIC
RNAse_Pc 26 142 6.52e-65 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the pancreatic ribonuclease A superfamily and is a potent inducer of neovascularization. The encoded protein is a secreted multifunctional tRNA-specific ribonuclease that promotes angiogenesis in response to angiogenetic stimuli such as hypoxia, mediates stress-induced translational repression by cleaving cellular tRNAs, stimulates cell proliferation by mediating rRNA transcription in prostate cancer cells, and is involved in neurite pathfinding. This gene resides in a cluster of highly related genes. It shares dual promoters and 5' exons with the ribonuclease, RNase A family 4 gene. Two alternatively spliced variants, with different 5' exons but the same coding exon, have been identified. Multiple pseudogenes have been found for this gene. [provided by RefSeq, Jun 2009]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610010F05Rik T G 11: 23,620,225 probably benign Het
Adad1 A T 3: 37,092,034 N517I probably damaging Het
Adam25 G A 8: 40,754,921 R408H probably benign Het
Ankrd42 T C 7: 92,610,585 T327A probably damaging Het
Birc6 A G 17: 74,631,687 D2696G probably damaging Het
Chd3 G A 11: 69,348,742 T1717M probably benign Het
Csmd1 T A 8: 16,200,055 M970L probably benign Het
Dhx32 T C 7: 133,748,977 I121M possibly damaging Het
Dnah11 G A 12: 118,020,232 S2506F possibly damaging Het
Dscam T A 16: 96,673,709 I1218F possibly damaging Het
Duox1 T C 2: 122,340,090 L1197P probably damaging Het
Eps8l2 T C 7: 141,361,375 probably benign Het
Exoc3 T C 13: 74,206,935 K49R probably damaging Het
Exoc8 T A 8: 124,895,841 T596S possibly damaging Het
F13a1 C T 13: 36,918,577 G391R probably null Het
Fam35a C A 14: 34,237,557 V823F probably damaging Het
Fat3 A T 9: 15,998,848 S1953T probably damaging Het
Gls2 C A 10: 128,201,347 N252K probably damaging Het
Gm5346 A T 8: 43,626,433 D251E probably benign Het
Haus2 G A 2: 120,615,942 R115K probably benign Het
Ift122 A G 6: 115,884,379 K262E probably benign Het
Islr2 C T 9: 58,198,378 C533Y probably damaging Het
Lrp2 A T 2: 69,443,716 F3997I possibly damaging Het
Nt5c1a C T 4: 123,216,169 R354W probably damaging Het
Olfr776 T A 10: 129,261,335 C125S probably damaging Het
Pcolce A T 5: 137,607,476 S200R probably damaging Het
Plec A G 15: 76,179,297 V2213A possibly damaging Het
Prmt3 T A 7: 49,780,372 D74E probably benign Het
Ptk7 A G 17: 46,565,387 F1046S probably damaging Het
Ranbp2 T C 10: 58,475,300 Y887H possibly damaging Het
Sez6l2 G A 7: 126,961,883 E447K possibly damaging Het
Snrnp70 C T 7: 45,387,236 probably null Het
Timm10 T A 2: 84,829,864 V49E probably damaging Het
Tox2 T C 2: 163,225,466 probably benign Het
Usp20 T A 2: 30,998,789 M1K probably null Het
Usp32 A C 11: 85,059,164 L223V probably damaging Het
Zeb1 T C 18: 5,767,138 S550P probably benign Het
Zeb1 G T 18: 5,767,906 A806S probably damaging Het
Other mutations in Ang
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1716:Ang UTSW 14 51101480 missense probably benign 0.01
R1716:Ang UTSW 14 51101500 missense probably damaging 1.00
R1989:Ang UTSW 14 51101551 missense probably damaging 1.00
R2407:Ang UTSW 14 51101646 nonsense probably null
R2860:Ang UTSW 14 51101818 missense probably damaging 1.00
R2861:Ang UTSW 14 51101818 missense probably damaging 1.00
R2862:Ang UTSW 14 51101818 missense probably damaging 1.00
R5807:Ang UTSW 14 51101429 intron probably benign
R7303:Ang UTSW 14 51101516 missense probably benign 0.02
R7322:Ang UTSW 14 51101411 missense unknown
R9334:Ang UTSW 14 51101560 missense possibly damaging 0.80
X0024:Ang UTSW 14 51101575 missense probably benign
Posted On 2013-11-11