Incidental Mutation 'IGL01444:Adam25'
ID 84347
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Adam25
Ensembl Gene ENSMUSG00000071937
Gene Name a disintegrin and metallopeptidase domain 25 (testase 2)
Synonyms testase 2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # IGL01444
Quality Score
Status
Chromosome 8
Chromosomal Location 40752208-40756176 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 40754921 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Arginine to Histidine at position 408 (R408H)
Ref Sequence ENSEMBL: ENSMUSP00000094420 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096663]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000096663
AA Change: R408H

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000094420
Gene: ENSMUSG00000071937
AA Change: R408H

DomainStartEndE-ValueType
Pfam:Pep_M12B_propep 53 179 3.4e-21 PFAM
Pfam:Reprolysin_5 220 398 1.6e-16 PFAM
Pfam:Reprolysin_4 220 407 2.5e-13 PFAM
Pfam:Reprolysin 221 410 5.6e-46 PFAM
Pfam:Reprolysin_2 222 399 9.7e-14 PFAM
Pfam:Reprolysin_3 246 366 1e-18 PFAM
DISIN 428 503 3.33e-39 SMART
ACR 504 640 8.95e-74 SMART
transmembrane domain 706 728 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is expressed in a regulated fashion during spermatogenesis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional metalloprotease enzyme. This gene is located adjacent to other ADAM genes on chromosome 8. [provided by RefSeq, May 2016]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610010F05Rik T G 11: 23,620,225 (GRCm38) probably benign Het
Adad1 A T 3: 37,092,034 (GRCm38) N517I probably damaging Het
Ang C A 14: 51,101,667 (GRCm38) Y88* probably null Het
Ankrd42 T C 7: 92,610,585 (GRCm38) T327A probably damaging Het
Birc6 A G 17: 74,631,687 (GRCm38) D2696G probably damaging Het
Chd3 G A 11: 69,348,742 (GRCm38) T1717M probably benign Het
Csmd1 T A 8: 16,200,055 (GRCm38) M970L probably benign Het
Dhx32 T C 7: 133,748,977 (GRCm38) I121M possibly damaging Het
Dnah11 G A 12: 118,020,232 (GRCm38) S2506F possibly damaging Het
Dscam T A 16: 96,673,709 (GRCm38) I1218F possibly damaging Het
Duox1 T C 2: 122,340,090 (GRCm38) L1197P probably damaging Het
Eps8l2 T C 7: 141,361,375 (GRCm38) probably benign Het
Exoc3 T C 13: 74,206,935 (GRCm38) K49R probably damaging Het
Exoc8 T A 8: 124,895,841 (GRCm38) T596S possibly damaging Het
F13a1 C T 13: 36,918,577 (GRCm38) G391R probably null Het
Fam35a C A 14: 34,237,557 (GRCm38) V823F probably damaging Het
Fat3 A T 9: 15,998,848 (GRCm38) S1953T probably damaging Het
Gls2 C A 10: 128,201,347 (GRCm38) N252K probably damaging Het
Gm5346 A T 8: 43,626,433 (GRCm38) D251E probably benign Het
Haus2 G A 2: 120,615,942 (GRCm38) R115K probably benign Het
Ift122 A G 6: 115,884,379 (GRCm38) K262E probably benign Het
Islr2 C T 9: 58,198,378 (GRCm38) C533Y probably damaging Het
Lrp2 A T 2: 69,443,716 (GRCm38) F3997I possibly damaging Het
Nt5c1a C T 4: 123,216,169 (GRCm38) R354W probably damaging Het
Olfr776 T A 10: 129,261,335 (GRCm38) C125S probably damaging Het
Pcolce A T 5: 137,607,476 (GRCm38) S200R probably damaging Het
Plec A G 15: 76,179,297 (GRCm38) V2213A possibly damaging Het
Prmt3 T A 7: 49,780,372 (GRCm38) D74E probably benign Het
Ptk7 A G 17: 46,565,387 (GRCm38) F1046S probably damaging Het
Ranbp2 T C 10: 58,475,300 (GRCm38) Y887H possibly damaging Het
Sez6l2 G A 7: 126,961,883 (GRCm38) E447K possibly damaging Het
Snrnp70 C T 7: 45,387,236 (GRCm38) probably null Het
Timm10 T A 2: 84,829,864 (GRCm38) V49E probably damaging Het
Tox2 T C 2: 163,225,466 (GRCm38) probably benign Het
Usp20 T A 2: 30,998,789 (GRCm38) M1K probably null Het
Usp32 A C 11: 85,059,164 (GRCm38) L223V probably damaging Het
Zeb1 G T 18: 5,767,906 (GRCm38) A806S probably damaging Het
Zeb1 T C 18: 5,767,138 (GRCm38) S550P probably benign Het
Other mutations in Adam25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01977:Adam25 APN 8 40,755,097 (GRCm38) missense probably benign 0.00
IGL02098:Adam25 APN 8 40,755,643 (GRCm38) missense probably benign 0.12
IGL02233:Adam25 APN 8 40,755,386 (GRCm38) missense probably damaging 1.00
IGL02458:Adam25 APN 8 40,753,807 (GRCm38) missense probably benign 0.01
IGL02527:Adam25 APN 8 40,753,748 (GRCm38) missense possibly damaging 0.78
IGL02632:Adam25 APN 8 40,755,200 (GRCm38) missense possibly damaging 0.90
IGL02995:Adam25 APN 8 40,753,723 (GRCm38) missense probably benign 0.00
H8786:Adam25 UTSW 8 40,754,224 (GRCm38) missense probably benign 0.00
R0062:Adam25 UTSW 8 40,754,792 (GRCm38) missense probably damaging 1.00
R0062:Adam25 UTSW 8 40,754,792 (GRCm38) missense probably damaging 1.00
R0189:Adam25 UTSW 8 40,755,430 (GRCm38) missense probably damaging 1.00
R0505:Adam25 UTSW 8 40,755,224 (GRCm38) missense probably damaging 1.00
R0532:Adam25 UTSW 8 40,755,950 (GRCm38) missense probably benign 0.00
R0699:Adam25 UTSW 8 40,755,974 (GRCm38) missense probably benign
R0972:Adam25 UTSW 8 40,755,131 (GRCm38) missense probably damaging 1.00
R1053:Adam25 UTSW 8 40,754,731 (GRCm38) missense probably benign 0.30
R1079:Adam25 UTSW 8 40,755,476 (GRCm38) missense possibly damaging 0.87
R1872:Adam25 UTSW 8 40,755,226 (GRCm38) nonsense probably null
R1933:Adam25 UTSW 8 40,754,885 (GRCm38) missense probably benign 0.01
R1934:Adam25 UTSW 8 40,754,885 (GRCm38) missense probably benign 0.01
R4061:Adam25 UTSW 8 40,753,782 (GRCm38) missense possibly damaging 0.67
R4702:Adam25 UTSW 8 40,754,126 (GRCm38) missense probably damaging 1.00
R4703:Adam25 UTSW 8 40,754,126 (GRCm38) missense probably damaging 1.00
R4705:Adam25 UTSW 8 40,754,126 (GRCm38) missense probably damaging 1.00
R4859:Adam25 UTSW 8 40,754,543 (GRCm38) missense probably benign 0.01
R5015:Adam25 UTSW 8 40,754,634 (GRCm38) missense probably benign 0.22
R5249:Adam25 UTSW 8 40,755,954 (GRCm38) missense probably benign
R5628:Adam25 UTSW 8 40,755,710 (GRCm38) missense probably benign 0.00
R5791:Adam25 UTSW 8 40,754,220 (GRCm38) missense probably benign
R6439:Adam25 UTSW 8 40,754,590 (GRCm38) missense possibly damaging 0.92
R6693:Adam25 UTSW 8 40,754,531 (GRCm38) missense probably damaging 1.00
R7041:Adam25 UTSW 8 40,754,084 (GRCm38) missense probably benign 0.04
R7101:Adam25 UTSW 8 40,755,401 (GRCm38) missense probably benign 0.00
R7531:Adam25 UTSW 8 40,753,877 (GRCm38) missense probably damaging 0.99
R7600:Adam25 UTSW 8 40,755,817 (GRCm38) missense probably benign 0.01
R7634:Adam25 UTSW 8 40,754,846 (GRCm38) missense probably benign 0.00
R7964:Adam25 UTSW 8 40,755,539 (GRCm38) missense probably damaging 0.99
R8017:Adam25 UTSW 8 40,754,087 (GRCm38) missense possibly damaging 0.56
R8021:Adam25 UTSW 8 40,754,759 (GRCm38) missense probably damaging 1.00
R8499:Adam25 UTSW 8 40,755,152 (GRCm38) missense probably damaging 1.00
R8686:Adam25 UTSW 8 40,755,484 (GRCm38) missense probably benign 0.44
R8715:Adam25 UTSW 8 40,754,062 (GRCm38) missense probably benign 0.00
R8847:Adam25 UTSW 8 40,753,709 (GRCm38) missense probably benign
R8921:Adam25 UTSW 8 40,754,673 (GRCm38) nonsense probably null
R9120:Adam25 UTSW 8 40,756,104 (GRCm38) utr 3 prime probably benign
R9158:Adam25 UTSW 8 40,755,608 (GRCm38) missense probably damaging 1.00
R9339:Adam25 UTSW 8 40,753,874 (GRCm38) missense probably damaging 1.00
R9348:Adam25 UTSW 8 40,755,916 (GRCm38) missense probably benign
R9454:Adam25 UTSW 8 40,754,449 (GRCm38) missense probably damaging 0.99
R9492:Adam25 UTSW 8 40,753,699 (GRCm38) start codon destroyed probably benign 0.12
R9680:Adam25 UTSW 8 40,755,202 (GRCm38) missense probably damaging 1.00
RF006:Adam25 UTSW 8 40,755,797 (GRCm38) missense probably benign
Posted On 2013-11-11