Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01446:Lratd1'

84413

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lratd1

Ensembl Gene

ENSMUSG00000020607

Gene Name

LRAT domain containing 1

Synonyms

Fam84a, 4731402F03Rik, 2310003N02Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.115) question?

Stock #

IGL01446

Quality Score

Status

Chromosome

Chromosomal Location

14197599-14202039 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 14199929 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 266 (I266N)

Ref Sequence

ENSEMBL: ENSMUSP00000020926 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000020926] [ENSMUST00000221405]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000020926
AA Change: I266N

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000020926
Gene: ENSMUSG00000020607
AA Change: I266N

Domain	Start	End	E-Value	Type
low complexity region	57	69	N/A	INTRINSIC
low complexity region	71	81	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000221405

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	A	G	11: 9,353,834 (GRCm39)	T3719A	probably damaging	Het
Acaca	A	G	11: 84,151,457 (GRCm39)	K785R	probably damaging	Het
Acsm3	G	A	7: 119,377,677 (GRCm39)	V401M	probably damaging	Het
Aff4	G	T	11: 53,306,296 (GRCm39)	R1146L	probably damaging	Het
Alms1	C	A	6: 85,673,683 (GRCm39)	P3562T	probably damaging	Het
Arsj	A	G	3: 126,232,463 (GRCm39)	E403G	probably benign	Het
Baiap2l1	C	T	5: 144,212,723 (GRCm39)	V431I	probably benign	Het
Cecr2	T	A	6: 120,735,560 (GRCm39)	M904K	probably benign	Het
Cenpe	A	T	3: 134,943,300 (GRCm39)	T775S	probably benign	Het
Dennd1b	G	A	1: 138,950,848 (GRCm39)	E30K	possibly damaging	Het
Dnah5	A	G	15: 28,326,815 (GRCm39)	D2008G	probably damaging	Het
Dnm2	T	C	9: 21,392,672 (GRCm39)	V460A	probably damaging	Het
Ell2	G	T	13: 75,910,110 (GRCm39)	L285F	probably benign	Het
Erg	A	G	16: 95,162,141 (GRCm39)	S322P	probably damaging	Het
Extl3	A	G	14: 65,314,529 (GRCm39)	F218L	probably benign	Het
Fzd9	T	C	5: 135,279,420 (GRCm39)	E155G	probably damaging	Het
Ghr	A	G	15: 3,362,837 (GRCm39)	W212R	probably damaging	Het
Gulp1	A	G	1: 44,783,708 (GRCm39)		probably benign	Het
Hdgfl2	C	T	17: 56,404,281 (GRCm39)	R332C	possibly damaging	Het
Nsd2	T	C	5: 34,018,530 (GRCm39)		probably benign	Het
Or4c12	A	G	2: 89,774,282 (GRCm39)	F59S	probably damaging	Het
Or5a3	T	C	19: 12,400,165 (GRCm39)	I164T	possibly damaging	Het
Or5b121	C	T	19: 13,507,616 (GRCm39)	T237I	probably benign	Het
Phf11b	A	C	14: 59,578,740 (GRCm39)	S9A	probably benign	Het
Psd4	T	C	2: 24,295,407 (GRCm39)	S854P	probably damaging	Het
Reln	C	T	5: 22,174,315 (GRCm39)	D1963N	probably damaging	Het
Rpe65	T	A	3: 159,306,042 (GRCm39)		probably benign	Het
Sdccag8	T	C	1: 176,672,811 (GRCm39)	S235P	probably damaging	Het
Sgip1	G	T	4: 102,786,110 (GRCm39)		probably null	Het
Skint5	G	A	4: 113,800,019 (GRCm39)	P36L	probably damaging	Het
Slc26a3	G	T	12: 31,502,490 (GRCm39)		probably benign	Het
Snx13	T	A	12: 35,174,479 (GRCm39)	C669*	probably null	Het
Svil	A	T	18: 5,062,385 (GRCm39)	T902S	probably damaging	Het
Syne2	T	C	12: 76,088,149 (GRCm39)	S4989P	probably damaging	Het
Ttn	G	A	2: 76,640,283 (GRCm39)	T13775M	probably damaging	Het
Ubr4	T	C	4: 139,165,351 (GRCm39)		probably benign	Het
Ush1c	C	T	7: 45,858,380 (GRCm39)	R636H	possibly damaging	Het
Usp17lc	A	T	7: 103,067,651 (GRCm39)	R315S	probably benign	Het
Vmn1r236	T	A	17: 21,506,918 (GRCm39)	V12D	probably benign	Het
Wsb2	T	G	5: 117,509,229 (GRCm39)	I170S	probably damaging	Het
Zfp800	G	A	6: 28,242,983 (GRCm39)	L661F	possibly damaging	Het

Other mutations in Lratd1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00910:Lratd1	APN	12	14,200,527 (GRCm39)	missense	probably benign	0.14
IGL02684:Lratd1	APN	12	14,200,646 (GRCm39)	missense	probably damaging	0.97
Grade	UTSW	12	14,199,864 (GRCm39)	missense	probably damaging	0.99
R1514:Lratd1	UTSW	12	14,199,864 (GRCm39)	missense	probably damaging	0.99
R1583:Lratd1	UTSW	12	14,200,409 (GRCm39)	missense	probably benign	0.25
R1800:Lratd1	UTSW	12	14,200,226 (GRCm39)	missense	probably damaging	0.98
R6074:Lratd1	UTSW	12	14,200,512 (GRCm39)	missense	probably benign	0.06
R6259:Lratd1	UTSW	12	14,200,646 (GRCm39)	missense	probably damaging	0.99
R7169:Lratd1	UTSW	12	14,200,619 (GRCm39)	missense	probably damaging	0.99
R9239:Lratd1	UTSW	12	14,200,185 (GRCm39)	missense	probably damaging	1.00
R9649:Lratd1	UTSW	12	14,200,190 (GRCm39)	missense	probably benign

Posted On

2013-11-11