Incidental Mutation 'IGL01447:Fbxw18'
| ID |
84446 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Fbxw18
|
| Ensembl Gene |
ENSMUSG00000074059 |
| Gene Name |
F-box and WD-40 domain protein 18 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.061)
|
| Stock # |
IGL01447
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
9 |
| Chromosomal Location |
109505802-109531768 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 109530675 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Cysteine
at position 41
(S41C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000095962
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000098359]
|
| AlphaFold |
Q3TSA9 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000098359
AA Change: S41C
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000095962
Gene: ENSMUSG00000074059
AA Change: S41C
| Domain | Start | End | E-Value | Type |
|---|
|
FBOX
|
8 |
48 |
4.13e-6 |
SMART |
|
Blast:WD40
|
140 |
179 |
2e-7 |
BLAST |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000198949
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 40 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Apbb1ip |
T |
G |
2: 22,743,194 (GRCm39) |
I342S |
probably damaging |
Het |
| Armh4 |
A |
T |
14: 50,005,923 (GRCm39) |
S591T |
probably damaging |
Het |
| Atp6v1e1 |
T |
C |
6: 120,772,654 (GRCm39) |
|
probably benign |
Het |
| Brwd1 |
A |
T |
16: 95,848,579 (GRCm39) |
C533* |
probably null |
Het |
| Cacna2d4 |
A |
G |
6: 119,219,865 (GRCm39) |
S212G |
probably damaging |
Het |
| Ccn5 |
A |
G |
2: 163,670,942 (GRCm39) |
R150G |
probably damaging |
Het |
| Cit |
T |
C |
5: 116,011,902 (GRCm39) |
|
probably benign |
Het |
| Clca3a1 |
C |
T |
3: 144,713,539 (GRCm39) |
M697I |
probably benign |
Het |
| Cmklr1 |
T |
C |
5: 113,752,282 (GRCm39) |
T240A |
probably benign |
Het |
| D630003M21Rik |
T |
C |
2: 158,059,276 (GRCm39) |
D208G |
probably benign |
Het |
| Egr3 |
C |
A |
14: 70,316,732 (GRCm39) |
P143Q |
probably damaging |
Het |
| Focad |
T |
A |
4: 88,244,465 (GRCm39) |
I815N |
unknown |
Het |
| Heatr5b |
T |
C |
17: 79,137,026 (GRCm39) |
T165A |
probably benign |
Het |
| Iqub |
G |
T |
6: 24,505,627 (GRCm39) |
L94I |
probably benign |
Het |
| Lrrc32 |
T |
C |
7: 98,147,583 (GRCm39) |
L121P |
probably damaging |
Het |
| Mansc1 |
G |
A |
6: 134,594,289 (GRCm39) |
L118F |
probably damaging |
Het |
| Mtor |
A |
G |
4: 148,615,214 (GRCm39) |
H1693R |
possibly damaging |
Het |
| Muc5b |
A |
G |
7: 141,416,831 (GRCm39) |
Q3259R |
probably benign |
Het |
| Nmnat2 |
A |
G |
1: 152,988,189 (GRCm39) |
S273G |
possibly damaging |
Het |
| Npr2 |
T |
C |
4: 43,640,554 (GRCm39) |
C336R |
possibly damaging |
Het |
| Or10al6 |
C |
T |
17: 38,083,122 (GRCm39) |
L193F |
probably damaging |
Het |
| Or1f19 |
A |
G |
16: 3,410,848 (GRCm39) |
N196S |
possibly damaging |
Het |
| Or1j11 |
A |
T |
2: 36,311,466 (GRCm39) |
I19F |
probably damaging |
Het |
| Or56b1b |
A |
G |
7: 108,164,216 (GRCm39) |
V262A |
possibly damaging |
Het |
| Or5aq1 |
A |
T |
2: 86,966,343 (GRCm39) |
Y107* |
probably null |
Het |
| Or5d36 |
T |
C |
2: 87,901,468 (GRCm39) |
N86S |
possibly damaging |
Het |
| Rad54l2 |
C |
T |
9: 106,579,971 (GRCm39) |
A967T |
probably damaging |
Het |
| Rspo1 |
T |
C |
4: 124,898,829 (GRCm39) |
V50A |
possibly damaging |
Het |
| Sar1b |
C |
T |
11: 51,682,274 (GRCm39) |
|
probably benign |
Het |
| Scamp1 |
C |
T |
13: 94,340,530 (GRCm39) |
A280T |
probably damaging |
Het |
| Spcs2 |
A |
G |
7: 99,488,911 (GRCm39) |
I251T |
probably benign |
Het |
| Sspo |
G |
T |
6: 48,441,600 (GRCm39) |
|
probably null |
Het |
| Tpm2 |
T |
A |
4: 43,518,251 (GRCm39) |
K251* |
probably null |
Het |
| Ttn |
A |
G |
2: 76,571,250 (GRCm39) |
S26548P |
probably damaging |
Het |
| Ugcg |
T |
G |
4: 59,213,865 (GRCm39) |
V149G |
possibly damaging |
Het |
| Unc79 |
T |
A |
12: 103,045,177 (GRCm39) |
N784K |
probably damaging |
Het |
| Vit |
A |
G |
17: 78,932,633 (GRCm39) |
D580G |
probably damaging |
Het |
| Vmn1r83 |
T |
C |
7: 12,055,424 (GRCm39) |
K211R |
probably benign |
Het |
| Zbtb3 |
A |
G |
19: 8,781,680 (GRCm39) |
Y431C |
probably damaging |
Het |
| Zfp608 |
T |
C |
18: 55,032,083 (GRCm39) |
D619G |
possibly damaging |
Het |
|
| Other mutations in Fbxw18 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00226:Fbxw18
|
APN |
9 |
109,522,411 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00820:Fbxw18
|
APN |
9 |
109,522,437 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01511:Fbxw18
|
APN |
9 |
109,517,889 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL01956:Fbxw18
|
APN |
9 |
109,522,425 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02089:Fbxw18
|
APN |
9 |
109,530,390 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4810001:Fbxw18
|
UTSW |
9 |
109,505,958 (GRCm39) |
nonsense |
probably null |
|
|
R0004:Fbxw18
|
UTSW |
9 |
109,530,381 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0124:Fbxw18
|
UTSW |
9 |
109,520,583 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0375:Fbxw18
|
UTSW |
9 |
109,517,907 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1652:Fbxw18
|
UTSW |
9 |
109,519,695 (GRCm39) |
missense |
probably benign |
0.35 |
|
R2153:Fbxw18
|
UTSW |
9 |
109,522,438 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2294:Fbxw18
|
UTSW |
9 |
109,505,865 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3738:Fbxw18
|
UTSW |
9 |
109,517,981 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R4706:Fbxw18
|
UTSW |
9 |
109,519,585 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4982:Fbxw18
|
UTSW |
9 |
109,531,719 (GRCm39) |
start gained |
probably benign |
|
|
R4990:Fbxw18
|
UTSW |
9 |
109,517,461 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5314:Fbxw18
|
UTSW |
9 |
109,522,246 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5520:Fbxw18
|
UTSW |
9 |
109,520,589 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5634:Fbxw18
|
UTSW |
9 |
109,505,871 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R5718:Fbxw18
|
UTSW |
9 |
109,520,636 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5894:Fbxw18
|
UTSW |
9 |
109,529,235 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R5928:Fbxw18
|
UTSW |
9 |
109,529,149 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6175:Fbxw18
|
UTSW |
9 |
109,505,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6696:Fbxw18
|
UTSW |
9 |
109,517,832 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6944:Fbxw18
|
UTSW |
9 |
109,531,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7396:Fbxw18
|
UTSW |
9 |
109,517,954 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7737:Fbxw18
|
UTSW |
9 |
109,530,331 (GRCm39) |
nonsense |
probably null |
|
|
R7883:Fbxw18
|
UTSW |
9 |
109,517,474 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9002:Fbxw18
|
UTSW |
9 |
109,519,660 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9053:Fbxw18
|
UTSW |
9 |
109,517,491 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9782:Fbxw18
|
UTSW |
9 |
109,522,376 (GRCm39) |
missense |
probably benign |
0.07 |
|
| Posted On |
2013-11-11 |
Incidental Mutation