Incidental Mutation 'IGL01447:Olfr1163'
ID84473
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1163
Ensembl Gene ENSMUSG00000075137
Gene Nameolfactory receptor 1163
SynonymsMOR174-8, GA_x6K02T2Q125-49563265-49562315
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.082) question?
Stock #IGL01447
Quality Score
Status
Chromosome2
Chromosomal Location88069817-88071830 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 88071124 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Serine at position 86 (N86S)
Ref Sequence ENSEMBL: ENSMUSP00000149399 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099835] [ENSMUST00000215268]
Predicted Effect possibly damaging
Transcript: ENSMUST00000099835
AA Change: N86S

PolyPhen 2 Score 0.559 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000097423
Gene: ENSMUSG00000075137
AA Change: N86S

DomainStartEndE-ValueType
Pfam:7tm_4 33 310 1.2e-44 PFAM
Pfam:7tm_1 43 292 2.3e-13 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215268
AA Change: N86S

PolyPhen 2 Score 0.559 (Sensitivity: 0.88; Specificity: 0.91)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3632451O06Rik A T 14: 49,768,466 S591T probably damaging Het
Apbb1ip T G 2: 22,853,182 I342S probably damaging Het
Atp6v1e1 T C 6: 120,795,693 probably benign Het
Brwd1 A T 16: 96,047,379 C533* probably null Het
Cacna2d4 A G 6: 119,242,904 S212G probably damaging Het
Cit T C 5: 115,873,843 probably benign Het
Clca1 C T 3: 145,007,778 M697I probably benign Het
Cmklr1 T C 5: 113,614,221 T240A probably benign Het
D630003M21Rik T C 2: 158,217,356 D208G probably benign Het
Egr3 C A 14: 70,079,283 P143Q probably damaging Het
Fbxw18 T A 9: 109,701,607 S41C probably damaging Het
Focad T A 4: 88,326,228 I815N unknown Het
Heatr5b T C 17: 78,829,597 T165A probably benign Het
Iqub G T 6: 24,505,628 L94I probably benign Het
Lrrc32 T C 7: 98,498,376 L121P probably damaging Het
Mansc1 G A 6: 134,617,326 L118F probably damaging Het
Mtor A G 4: 148,530,757 H1693R possibly damaging Het
Muc5b A G 7: 141,863,094 Q3259R probably benign Het
Nmnat2 A G 1: 153,112,443 S273G possibly damaging Het
Npr2 T C 4: 43,640,554 C336R possibly damaging Het
Olfr1110 A T 2: 87,135,999 Y107* probably null Het
Olfr122 C T 17: 37,772,231 L193F probably damaging Het
Olfr161 A G 16: 3,592,984 N196S possibly damaging Het
Olfr339 A T 2: 36,421,454 I19F probably damaging Het
Olfr504 A G 7: 108,565,009 V262A possibly damaging Het
Rad54l2 C T 9: 106,702,772 A967T probably damaging Het
Rspo1 T C 4: 125,005,036 V50A possibly damaging Het
Sar1b C T 11: 51,791,447 probably benign Het
Scamp1 C T 13: 94,204,022 A280T probably damaging Het
Spcs2 A G 7: 99,839,704 I251T probably benign Het
Sspo G T 6: 48,464,666 probably null Het
Tpm2 T A 4: 43,518,251 K251* probably null Het
Ttn A G 2: 76,740,906 S26548P probably damaging Het
Ugcg T G 4: 59,213,865 V149G possibly damaging Het
Unc79 T A 12: 103,078,918 N784K probably damaging Het
Vit A G 17: 78,625,204 D580G probably damaging Het
Vmn1r83 T C 7: 12,321,497 K211R probably benign Het
Wisp2 A G 2: 163,829,022 R150G probably damaging Het
Zbtb3 A G 19: 8,804,316 Y431C probably damaging Het
Zfp608 T C 18: 54,899,011 D619G possibly damaging Het
Other mutations in Olfr1163
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01472:Olfr1163 APN 2 88070978 missense possibly damaging 0.56
IGL02111:Olfr1163 APN 2 88071227 missense probably benign 0.22
R1274:Olfr1163 UTSW 2 88070595 missense probably damaging 1.00
R1938:Olfr1163 UTSW 2 88070956 missense probably damaging 1.00
R2012:Olfr1163 UTSW 2 88070719 missense probably benign 0.03
R3056:Olfr1163 UTSW 2 88071239 missense probably benign
R4127:Olfr1163 UTSW 2 88071235 missense probably benign 0.00
R4748:Olfr1163 UTSW 2 88070612 missense probably benign 0.44
R4749:Olfr1163 UTSW 2 88070612 missense probably benign 0.44
R4769:Olfr1163 UTSW 2 88070729 missense probably benign 0.25
R6647:Olfr1163 UTSW 2 88070709 missense probably benign 0.03
R7111:Olfr1163 UTSW 2 88070656 missense probably damaging 1.00
R7168:Olfr1163 UTSW 2 88070577 missense probably benign 0.37
Posted On2013-11-11