Incidental Mutation 'IGL01448:Olfr497'
ID84490
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr497
Ensembl Gene ENSMUSG00000095239
Gene Nameolfactory receptor 497
SynonymsGA_x6K02T2PBJ9-10752603-10753547, MOR204-9
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.075) question?
Stock #IGL01448
Quality Score
Status
Chromosome7
Chromosomal Location108420421-108424911 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) T to A at 108423028 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Stop codon at position 152 (Y152*)
Ref Sequence ENSEMBL: ENSMUSP00000150439 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076406] [ENSMUST00000213521]
Predicted Effect probably null
Transcript: ENSMUST00000076406
AA Change: Y152*
SMART Domains Protein: ENSMUSP00000075741
Gene: ENSMUSG00000095239
AA Change: Y152*

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 5.5e-55 PFAM
Pfam:7tm_1 44 293 1.4e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211454
AA Change: Y152*
Predicted Effect probably null
Transcript: ENSMUST00000213521
AA Change: Y152*
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700020A23Rik A T 2: 130,405,847 E75D possibly damaging Het
1700084J12Rik A G 15: 33,405,633 probably benign Het
2610303G11Rik T A 9: 98,186,709 noncoding transcript Het
4931414P19Rik T C 14: 54,585,960 D320G possibly damaging Het
Adamts6 G A 13: 104,297,164 E34K probably damaging Het
Alms1 T A 6: 85,677,899 N3142K possibly damaging Het
Anapc7 G A 5: 122,428,213 A62T probably damaging Het
Atp8b3 G A 10: 80,520,422 P1152L probably benign Het
Cc2d2a C T 5: 43,684,185 T181I possibly damaging Het
Celsr2 A G 3: 108,393,239 L2835P probably damaging Het
Ctns A T 11: 73,188,722 V99D possibly damaging Het
Dchs1 T C 7: 105,771,927 R429G probably damaging Het
Ddx11 T C 17: 66,134,137 V218A probably damaging Het
Eftud2 G A 11: 102,865,563 probably benign Het
Erich1 G T 8: 14,078,853 T29N possibly damaging Het
Exosc8 T C 3: 54,729,265 E215G probably damaging Het
Fam184a G T 10: 53,698,949 A188E probably benign Het
Fign A G 2: 63,979,688 S413P probably damaging Het
Fkbp6 A G 5: 135,349,696 S33P probably damaging Het
Glb1 A G 9: 114,450,677 probably benign Het
H2-Q1 T C 17: 35,323,461 probably benign Het
Helz2 T C 2: 181,233,977 T1575A probably damaging Het
Il18r1 A G 1: 40,474,730 E32G probably damaging Het
Ints5 C T 19: 8,895,487 P270L possibly damaging Het
Itga7 G T 10: 128,949,468 E847* probably null Het
Kcns3 A C 12: 11,091,643 S352A possibly damaging Het
Kiz A G 2: 146,863,801 K94E probably benign Het
Lin7b C T 7: 45,369,200 V12M probably damaging Het
Myo18b A T 5: 112,811,704 I1409N probably damaging Het
Myo5b A G 18: 74,644,090 H407R probably damaging Het
Nelfa T C 5: 33,898,802 T506A probably damaging Het
Olfr763 A G 10: 129,011,860 T192A probably damaging Het
Olfr816 A G 10: 129,912,245 I11T possibly damaging Het
Olfr984 A T 9: 40,101,082 M136K probably damaging Het
Pclo A C 5: 14,676,394 probably benign Het
Pes1 G A 11: 3,977,979 E544K possibly damaging Het
Rabgap1l A G 1: 160,740,745 probably benign Het
Rapgef2 C T 3: 79,103,962 probably null Het
Rapgef2 T C 3: 79,068,937 M1521V probably benign Het
Reln A G 5: 22,040,405 V735A probably benign Het
Slc2a4 A G 11: 69,945,076 S316P possibly damaging Het
Smarce1 C T 11: 99,210,187 G373E possibly damaging Het
Spata31d1a T A 13: 59,701,559 R918S probably benign Het
St3gal4 T C 9: 35,052,331 K227R probably benign Het
Stra6l T A 4: 45,864,864 probably null Het
Stxbp5l T C 16: 37,215,979 I425V probably damaging Het
Tcaf2 T C 6: 42,630,328 T231A probably benign Het
Tiparp G T 3: 65,552,609 G442* probably null Het
Tnks A G 8: 34,839,982 Y1138H probably damaging Het
Vezt T A 10: 93,996,857 I231F probably damaging Het
Vmn2r4 A T 3: 64,406,395 N388K probably damaging Het
Zbed3 A G 13: 95,336,634 K189E possibly damaging Het
Zfp512b T C 2: 181,587,785 T625A possibly damaging Het
Zfp827 A T 8: 79,060,733 Q176L possibly damaging Het
Other mutations in Olfr497
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03145:Olfr497 APN 7 108422599 missense probably benign 0.00
R0732:Olfr497 UTSW 7 108422577 missense probably benign 0.00
R1892:Olfr497 UTSW 7 108422940 missense possibly damaging 0.61
R2008:Olfr497 UTSW 7 108423182 missense probably benign 0.01
R3721:Olfr497 UTSW 7 108423119 missense probably damaging 1.00
R4497:Olfr497 UTSW 7 108422915 missense probably benign 0.37
R4674:Olfr497 UTSW 7 108423102 missense possibly damaging 0.65
R4675:Olfr497 UTSW 7 108423102 missense possibly damaging 0.65
R4695:Olfr497 UTSW 7 108422989 missense probably benign 0.18
R5265:Olfr497 UTSW 7 108423402 missense possibly damaging 0.94
R5656:Olfr497 UTSW 7 108422618 missense probably benign 0.03
R5758:Olfr497 UTSW 7 108423162 missense probably benign 0.02
R6124:Olfr497 UTSW 7 108423518 unclassified probably null
R6787:Olfr497 UTSW 7 108422682 missense possibly damaging 0.52
R7174:Olfr497 UTSW 7 108423160 missense probably benign 0.01
R7222:Olfr497 UTSW 7 108422637 missense probably benign 0.00
R7240:Olfr497 UTSW 7 108422933 missense probably damaging 1.00
Posted On2013-11-11