Incidental Mutation 'IGL01448:Zfp827'
ID 84511
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp827
Ensembl Gene ENSMUSG00000071064
Gene Name zinc finger protein 827
Synonyms D630040G17Rik, 2810449M09Rik
Accession Numbers
Essential gene? Probably essential (E-score: 0.912) question?
Stock # IGL01448
Quality Score
Status
Chromosome 8
Chromosomal Location 79755066-79920395 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 79787362 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Leucine at position 176 (Q176L)
Ref Sequence ENSEMBL: ENSMUSP00000113199 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087927] [ENSMUST00000098614] [ENSMUST00000119254]
AlphaFold Q505G8
Predicted Effect probably benign
Transcript: ENSMUST00000087927
AA Change: Q176L

PolyPhen 2 Score 0.428 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000085238
Gene: ENSMUSG00000071064
AA Change: Q176L

DomainStartEndE-ValueType
low complexity region 102 128 N/A INTRINSIC
low complexity region 226 256 N/A INTRINSIC
low complexity region 271 298 N/A INTRINSIC
low complexity region 306 342 N/A INTRINSIC
low complexity region 343 348 N/A INTRINSIC
ZnF_C2H2 371 393 6.78e-3 SMART
ZnF_C2H2 399 422 5.59e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000098614
AA Change: Q176L

PolyPhen 2 Score 0.428 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000096214
Gene: ENSMUSG00000071064
AA Change: Q176L

DomainStartEndE-ValueType
low complexity region 102 128 N/A INTRINSIC
low complexity region 226 256 N/A INTRINSIC
low complexity region 271 298 N/A INTRINSIC
low complexity region 306 342 N/A INTRINSIC
low complexity region 343 348 N/A INTRINSIC
ZnF_C2H2 371 393 6.78e-3 SMART
ZnF_C2H2 399 421 2.99e-4 SMART
ZnF_C2H2 430 452 5.42e-2 SMART
internal_repeat_2 561 585 3.31e-7 PROSPERO
low complexity region 613 627 N/A INTRINSIC
internal_repeat_2 719 743 3.31e-7 PROSPERO
ZnF_C2H2 814 836 2.4e-3 SMART
ZnF_C2H2 842 864 4.72e-2 SMART
ZnF_C2H2 894 916 1.64e-1 SMART
ZnF_C2H2 926 949 7.89e0 SMART
low complexity region 956 974 N/A INTRINSIC
ZnF_C2H2 1016 1038 1.26e-2 SMART
ZnF_C2H2 1044 1066 3.07e-1 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000119254
AA Change: Q176L

PolyPhen 2 Score 0.816 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000113199
Gene: ENSMUSG00000071064
AA Change: Q176L

DomainStartEndE-ValueType
low complexity region 102 128 N/A INTRINSIC
low complexity region 226 256 N/A INTRINSIC
low complexity region 271 298 N/A INTRINSIC
low complexity region 306 342 N/A INTRINSIC
low complexity region 343 348 N/A INTRINSIC
ZnF_C2H2 371 393 6.78e-3 SMART
ZnF_C2H2 399 421 2.99e-4 SMART
ZnF_C2H2 430 452 5.42e-2 SMART
internal_repeat_2 561 585 3.25e-7 PROSPERO
low complexity region 613 627 N/A INTRINSIC
internal_repeat_2 719 743 3.25e-7 PROSPERO
ZnF_C2H2 814 836 2.4e-3 SMART
ZnF_C2H2 842 864 4.72e-2 SMART
ZnF_C2H2 894 916 1.64e-1 SMART
ZnF_C2H2 926 949 7.89e0 SMART
low complexity region 956 974 N/A INTRINSIC
ZnF_C2H2 1016 1038 1.26e-2 SMART
ZnF_C2H2 1044 1066 3.07e-1 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700020A23Rik A T 2: 130,247,767 (GRCm39) E75D possibly damaging Het
1700084J12Rik A G 15: 33,405,779 (GRCm39) probably benign Het
2610303G11Rik T A 9: 98,068,762 (GRCm39) noncoding transcript Het
4931414P19Rik T C 14: 54,823,417 (GRCm39) D320G possibly damaging Het
Adamts6 G A 13: 104,433,672 (GRCm39) E34K probably damaging Het
Alms1 T A 6: 85,654,881 (GRCm39) N3142K possibly damaging Het
Anapc7 G A 5: 122,566,276 (GRCm39) A62T probably damaging Het
Atp8b3 G A 10: 80,356,256 (GRCm39) P1152L probably benign Het
Cc2d2a C T 5: 43,841,527 (GRCm39) T181I possibly damaging Het
Celsr2 A G 3: 108,300,555 (GRCm39) L2835P probably damaging Het
Ctns A T 11: 73,079,548 (GRCm39) V99D possibly damaging Het
Dchs1 T C 7: 105,421,134 (GRCm39) R429G probably damaging Het
Ddx11 T C 17: 66,441,132 (GRCm39) V218A probably damaging Het
Eftud2 G A 11: 102,756,389 (GRCm39) probably benign Het
Erich1 G T 8: 14,128,853 (GRCm39) T29N possibly damaging Het
Exosc8 T C 3: 54,636,686 (GRCm39) E215G probably damaging Het
Fam184a G T 10: 53,575,045 (GRCm39) A188E probably benign Het
Fign A G 2: 63,810,032 (GRCm39) S413P probably damaging Het
Fkbp6 A G 5: 135,378,550 (GRCm39) S33P probably damaging Het
Glb1 A G 9: 114,279,745 (GRCm39) probably benign Het
H2-Q1 T C 17: 35,542,437 (GRCm39) probably benign Het
Helz2 T C 2: 180,875,770 (GRCm39) T1575A probably damaging Het
Il18r1 A G 1: 40,513,890 (GRCm39) E32G probably damaging Het
Ints5 C T 19: 8,872,851 (GRCm39) P270L possibly damaging Het
Itga7 G T 10: 128,785,337 (GRCm39) E847* probably null Het
Kcns3 A C 12: 11,141,644 (GRCm39) S352A possibly damaging Het
Kiz A G 2: 146,705,721 (GRCm39) K94E probably benign Het
Lin7b C T 7: 45,018,624 (GRCm39) V12M probably damaging Het
Myo18b A T 5: 112,959,570 (GRCm39) I1409N probably damaging Het
Myo5b A G 18: 74,777,161 (GRCm39) H407R probably damaging Het
Nelfa T C 5: 34,056,146 (GRCm39) T506A probably damaging Het
Or10p21 A G 10: 128,847,729 (GRCm39) T192A probably damaging Het
Or4d5 A T 9: 40,012,378 (GRCm39) M136K probably damaging Het
Or5p72 T A 7: 108,022,235 (GRCm39) Y152* probably null Het
Or6c69 A G 10: 129,748,114 (GRCm39) I11T possibly damaging Het
Pclo A C 5: 14,726,408 (GRCm39) probably benign Het
Pes1 G A 11: 3,927,979 (GRCm39) E544K possibly damaging Het
Rabgap1l A G 1: 160,568,315 (GRCm39) probably benign Het
Rapgef2 T C 3: 78,976,244 (GRCm39) M1521V probably benign Het
Rapgef2 C T 3: 79,011,269 (GRCm39) probably null Het
Reln A G 5: 22,245,403 (GRCm39) V735A probably benign Het
Slc2a4 A G 11: 69,835,902 (GRCm39) S316P possibly damaging Het
Smarce1 C T 11: 99,101,013 (GRCm39) G373E possibly damaging Het
Spata31d1a T A 13: 59,849,373 (GRCm39) R918S probably benign Het
St3gal4 T C 9: 34,963,627 (GRCm39) K227R probably benign Het
Stra6l T A 4: 45,864,864 (GRCm39) probably null Het
Stxbp5l T C 16: 37,036,341 (GRCm39) I425V probably damaging Het
Tcaf2 T C 6: 42,607,262 (GRCm39) T231A probably benign Het
Tiparp G T 3: 65,460,030 (GRCm39) G442* probably null Het
Tnks A G 8: 35,307,136 (GRCm39) Y1138H probably damaging Het
Vezt T A 10: 93,832,719 (GRCm39) I231F probably damaging Het
Vmn2r4 A T 3: 64,313,816 (GRCm39) N388K probably damaging Het
Zbed3 A G 13: 95,473,142 (GRCm39) K189E possibly damaging Het
Zfp512b T C 2: 181,229,578 (GRCm39) T625A possibly damaging Het
Other mutations in Zfp827
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01545:Zfp827 APN 8 79,797,063 (GRCm39) missense probably damaging 1.00
IGL01552:Zfp827 APN 8 79,802,820 (GRCm39) missense probably damaging 1.00
IGL02261:Zfp827 APN 8 79,906,708 (GRCm39) missense probably damaging 0.97
IGL02451:Zfp827 APN 8 79,787,601 (GRCm39) missense probably damaging 1.00
IGL03130:Zfp827 APN 8 79,787,586 (GRCm39) missense probably damaging 1.00
IGL03411:Zfp827 APN 8 79,803,116 (GRCm39) missense probably damaging 0.99
E0354:Zfp827 UTSW 8 79,863,206 (GRCm39) missense probably damaging 1.00
R0502:Zfp827 UTSW 8 79,905,706 (GRCm39) splice site probably null
R0547:Zfp827 UTSW 8 79,786,939 (GRCm39) missense probably damaging 1.00
R0926:Zfp827 UTSW 8 79,844,821 (GRCm39) missense probably benign 0.00
R0975:Zfp827 UTSW 8 79,787,814 (GRCm39) missense probably benign 0.00
R1305:Zfp827 UTSW 8 79,787,523 (GRCm39) missense possibly damaging 0.95
R1462:Zfp827 UTSW 8 79,803,108 (GRCm39) missense probably benign
R1462:Zfp827 UTSW 8 79,803,108 (GRCm39) missense probably benign
R1638:Zfp827 UTSW 8 79,802,975 (GRCm39) missense possibly damaging 0.94
R1714:Zfp827 UTSW 8 79,787,202 (GRCm39) missense probably damaging 1.00
R2044:Zfp827 UTSW 8 79,802,865 (GRCm39) missense probably benign
R2132:Zfp827 UTSW 8 79,912,350 (GRCm39) missense possibly damaging 0.53
R3844:Zfp827 UTSW 8 79,863,248 (GRCm39) missense probably damaging 0.99
R4329:Zfp827 UTSW 8 79,916,463 (GRCm39) utr 3 prime probably benign
R4629:Zfp827 UTSW 8 79,787,011 (GRCm39) missense probably damaging 0.99
R4873:Zfp827 UTSW 8 79,787,403 (GRCm39) missense probably damaging 1.00
R4875:Zfp827 UTSW 8 79,787,403 (GRCm39) missense probably damaging 1.00
R4936:Zfp827 UTSW 8 79,787,812 (GRCm39) missense probably benign
R4965:Zfp827 UTSW 8 79,787,910 (GRCm39) missense probably benign
R5103:Zfp827 UTSW 8 79,797,032 (GRCm39) missense probably damaging 1.00
R5366:Zfp827 UTSW 8 79,912,333 (GRCm39) missense possibly damaging 0.94
R5794:Zfp827 UTSW 8 79,797,071 (GRCm39) missense probably damaging 1.00
R5825:Zfp827 UTSW 8 79,905,645 (GRCm39) missense probably damaging 1.00
R6118:Zfp827 UTSW 8 79,803,067 (GRCm39) missense possibly damaging 0.75
R6236:Zfp827 UTSW 8 79,797,105 (GRCm39) missense probably damaging 1.00
R6263:Zfp827 UTSW 8 79,905,702 (GRCm39) missense probably damaging 1.00
R6306:Zfp827 UTSW 8 79,787,324 (GRCm39) missense probably damaging 1.00
R6490:Zfp827 UTSW 8 79,916,606 (GRCm39) utr 3 prime probably benign
R6497:Zfp827 UTSW 8 79,906,757 (GRCm39) missense probably damaging 1.00
R7250:Zfp827 UTSW 8 79,916,721 (GRCm39) missense
R7290:Zfp827 UTSW 8 79,916,442 (GRCm39) missense possibly damaging 0.86
R7443:Zfp827 UTSW 8 79,917,047 (GRCm39) missense
R7708:Zfp827 UTSW 8 79,902,591 (GRCm39) missense probably damaging 1.00
R7754:Zfp827 UTSW 8 79,916,958 (GRCm39) missense
R7836:Zfp827 UTSW 8 79,912,979 (GRCm39) missense probably damaging 1.00
R7995:Zfp827 UTSW 8 79,844,887 (GRCm39) missense possibly damaging 0.86
R8162:Zfp827 UTSW 8 79,787,206 (GRCm39) nonsense probably null
R8747:Zfp827 UTSW 8 79,755,316 (GRCm39) start codon destroyed probably null
R8798:Zfp827 UTSW 8 79,916,463 (GRCm39) utr 3 prime probably benign
R8980:Zfp827 UTSW 8 79,803,092 (GRCm39) missense probably benign 0.00
R9099:Zfp827 UTSW 8 79,917,107 (GRCm39) missense
R9178:Zfp827 UTSW 8 79,818,564 (GRCm39) missense probably damaging 1.00
R9246:Zfp827 UTSW 8 79,803,132 (GRCm39) missense possibly damaging 0.75
R9277:Zfp827 UTSW 8 79,787,029 (GRCm39) missense probably damaging 0.97
R9318:Zfp827 UTSW 8 79,844,982 (GRCm39) missense possibly damaging 0.75
R9339:Zfp827 UTSW 8 79,844,887 (GRCm39) missense probably benign 0.00
R9425:Zfp827 UTSW 8 79,905,588 (GRCm39) missense probably damaging 1.00
R9499:Zfp827 UTSW 8 79,787,403 (GRCm39) missense probably damaging 1.00
R9544:Zfp827 UTSW 8 79,905,604 (GRCm39) missense probably damaging 1.00
R9551:Zfp827 UTSW 8 79,787,403 (GRCm39) missense probably damaging 1.00
R9552:Zfp827 UTSW 8 79,787,403 (GRCm39) missense probably damaging 1.00
R9588:Zfp827 UTSW 8 79,905,604 (GRCm39) missense probably damaging 1.00
R9665:Zfp827 UTSW 8 79,906,756 (GRCm39) missense possibly damaging 0.89
Posted On 2013-11-11