Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01449:Cyp2a22'

84553

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp2a22

Ensembl Gene

ENSMUSG00000091867

Gene Name

cytochrome P450, family 2, subfamily a, polypeptide 22

Synonyms

EG233005

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.082) question?

Stock #

IGL01449

Quality Score

Status

Chromosome

Chromosomal Location

26931631-26939384 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 26933553 bp

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 408 (D408G)

Ref Sequence

ENSEMBL: ENSMUSP00000128030 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170227]

Predicted Effect

probably benign
Transcript: ENSMUST00000170227
AA Change: D408G

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000128030
Gene: ENSMUSG00000091867
AA Change: D408G

Domain	Start	End	E-Value	Type
signal peptide	1	30	N/A	INTRINSIC
Pfam:p450	33	489	7.4e-148	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206638

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206957

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700030K09Rik	A	T	8: 72,444,849	L33F	probably benign	Het
Actr8	T	C	14: 29,990,970		probably null	Het
Aldh16a1	C	A	7: 45,141,967	A105S	probably damaging	Het
Angpt2	T	C	8: 18,710,625	T154A	probably benign	Het
BC051665	A	G	13: 60,782,704	V278A	probably damaging	Het
Cap1	T	C	4: 122,860,187	T458A	probably damaging	Het
Clcn3	A	T	8: 60,934,598	S179T	probably damaging	Het
D430042O09Rik	T	A	7: 125,870,685	V1442D	probably damaging	Het
Fam217b	T	A	2: 178,421,150	S302R	probably damaging	Het
Fcho2	A	T	13: 98,789,807	D89E	probably benign	Het
Fnip1	C	T	11: 54,499,508	R434C	probably damaging	Het
Gga3	G	A	11: 115,589,102	T261M	probably damaging	Het
Gm21985	T	C	2: 112,339,396	F292L	probably damaging	Het
Gm43638	A	T	5: 87,486,215	S178T	possibly damaging	Het
Igkv10-95	G	A	6: 68,680,764	G68E	probably damaging	Het
Lpcat2	G	A	8: 92,871,147	R180Q	possibly damaging	Het
Muc6	C	T	7: 141,638,614	A1984T	possibly damaging	Het
Npy4r	T	A	14: 34,146,365	Y322F	probably damaging	Het
Nwd2	T	A	5: 63,805,594	H840Q	probably damaging	Het
Olfr844	G	A	9: 19,319,233	G233D	probably damaging	Het
Osbpl2	G	T	2: 180,145,194		probably benign	Het
Pclo	T	A	5: 14,678,516		probably benign	Het
Pold4	T	C	19: 4,232,867		probably benign	Het
Ppp1r16a	A	G	15: 76,694,294		probably benign	Het
Pprc1	C	T	19: 46,065,232		probably benign	Het
Prkcg	A	G	7: 3,319,619	D343G	probably benign	Het
Scaf11	A	C	15: 96,419,126	S852R	probably benign	Het
Slc31a2	C	T	4: 62,292,696	T22I	probably damaging	Het
Sox30	T	A	11: 45,981,342	D341E	probably damaging	Het
Tle4	A	G	19: 14,465,340	S339P	probably benign	Het
Tsg101	A	T	7: 46,908,925	Y78N	probably damaging	Het
Ttc1	T	A	11: 43,738,803	S179C	probably damaging	Het
Txnrd3	T	A	6: 89,654,147	S142T	probably benign	Het
Ubr4	C	A	4: 139,412,736	A1210E	probably damaging	Het
Uroc1	C	A	6: 90,338,653	P172Q	probably damaging	Het
Usp12	T	C	5: 146,754,440	D168G	probably benign	Het
Vmn1r32	T	A	6: 66,552,932	M287L	probably benign	Het
Vwa8	C	T	14: 79,182,988	Q1710*	probably null	Het
Wdfy4	T	A	14: 33,104,037	Q1219L	probably damaging	Het
Zbtb17	A	G	4: 141,463,305	T145A	probably benign	Het
Zfp697	T	C	3: 98,427,530	C204R	probably damaging	Het

Other mutations in Cyp2a22

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00156:Cyp2a22	APN	7	26937738	missense	probably benign	0.09
IGL01111:Cyp2a22	APN	7	26936458	missense	probably damaging	1.00
IGL01388:Cyp2a22	APN	7	26937792	missense	probably benign	0.02
IGL01642:Cyp2a22	APN	7	26938759	missense	possibly damaging	0.81
IGL02253:Cyp2a22	APN	7	26938237	splice site	probably benign
IGL02327:Cyp2a22	APN	7	26934781	missense	probably damaging	0.99
IGL02673:Cyp2a22	APN	7	26938100	missense	probably benign	0.00
IGL02813:Cyp2a22	APN	7	26936434	missense	probably benign	0.19
IGL02896:Cyp2a22	APN	7	26936461	missense	probably damaging	0.98
IGL03193:Cyp2a22	APN	7	26936421	missense	probably benign	0.00
IGL03350:Cyp2a22	APN	7	26934854	missense	possibly damaging	0.88
R1648:Cyp2a22	UTSW	7	26932368	missense	probably damaging	0.98
R1679:Cyp2a22	UTSW	7	26936311	nonsense	probably null
R1733:Cyp2a22	UTSW	7	26934762	missense	possibly damaging	0.78
R2001:Cyp2a22	UTSW	7	26934772	missense	probably damaging	1.00
R2858:Cyp2a22	UTSW	7	26934262	missense	probably damaging	0.99
R3054:Cyp2a22	UTSW	7	26938829	missense	probably damaging	1.00
R4528:Cyp2a22	UTSW	7	26934769	missense	possibly damaging	0.95
R4623:Cyp2a22	UTSW	7	26933491	missense	probably damaging	1.00
R4669:Cyp2a22	UTSW	7	26937855	missense	possibly damaging	0.88
R4690:Cyp2a22	UTSW	7	26939209	nonsense	probably null
R4840:Cyp2a22	UTSW	7	26932524	missense	probably benign	0.13
R4915:Cyp2a22	UTSW	7	26937770	missense	probably benign	0.33
R5071:Cyp2a22	UTSW	7	26932481	missense	probably benign	0.01
R5072:Cyp2a22	UTSW	7	26932481	missense	probably benign	0.01
R5074:Cyp2a22	UTSW	7	26932481	missense	probably benign	0.01
R5147:Cyp2a22	UTSW	7	26936325	missense	probably damaging	1.00
R5363:Cyp2a22	UTSW	7	26936433	missense	probably damaging	0.99
R5705:Cyp2a22	UTSW	7	26939215	missense	probably benign	0.05
R6014:Cyp2a22	UTSW	7	26939180	splice site	probably null
R6042:Cyp2a22	UTSW	7	26934239	missense	probably damaging	1.00
R6253:Cyp2a22	UTSW	7	26934232	missense	probably benign	0.18
R6757:Cyp2a22	UTSW	7	26939204	missense	probably benign	0.00
R6994:Cyp2a22	UTSW	7	26939181	critical splice donor site	probably null
R7581:Cyp2a22	UTSW	7	26938148	missense	possibly damaging	0.87
R8212:Cyp2a22	UTSW	7	26937780	missense	possibly damaging	0.89

Posted On

2013-11-11