Incidental Mutation 'IGL01449:Zfp697'
ID84564
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp697
Ensembl Gene ENSMUSG00000050064
Gene Namezinc finger protein 697
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.084) question?
Stock #IGL01449
Quality Score
Status
Chromosome3
Chromosomal Location98382461-98753812 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 98427530 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Arginine at position 204 (C204R)
Ref Sequence ENSEMBL: ENSMUSP00000136417 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056096] [ENSMUST00000178372]
Predicted Effect probably damaging
Transcript: ENSMUST00000056096
AA Change: C204R

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000056979
Gene: ENSMUSG00000050064
AA Change: C204R

DomainStartEndE-ValueType
low complexity region 83 96 N/A INTRINSIC
low complexity region 124 135 N/A INTRINSIC
low complexity region 157 168 N/A INTRINSIC
ZnF_C2H2 202 224 3.72e0 SMART
low complexity region 245 268 N/A INTRINSIC
ZnF_C2H2 280 302 3.63e-3 SMART
ZnF_C2H2 308 330 1.76e-1 SMART
ZnF_C2H2 336 358 6.78e-3 SMART
ZnF_C2H2 377 399 2.57e-3 SMART
ZnF_C2H2 405 427 2.09e-3 SMART
ZnF_C2H2 433 455 7.26e-3 SMART
ZnF_C2H2 461 483 6.42e-4 SMART
ZnF_C2H2 489 511 2.91e-2 SMART
ZnF_C2H2 517 539 9.73e-4 SMART
ZnF_C2H2 545 567 1.43e-1 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000178372
AA Change: C204R

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000136417
Gene: ENSMUSG00000050064
AA Change: C204R

DomainStartEndE-ValueType
low complexity region 83 96 N/A INTRINSIC
low complexity region 124 135 N/A INTRINSIC
low complexity region 157 168 N/A INTRINSIC
ZnF_C2H2 202 224 3.72e0 SMART
low complexity region 245 268 N/A INTRINSIC
ZnF_C2H2 280 302 3.63e-3 SMART
ZnF_C2H2 308 330 1.76e-1 SMART
ZnF_C2H2 336 358 6.78e-3 SMART
ZnF_C2H2 377 399 2.57e-3 SMART
ZnF_C2H2 405 427 2.09e-3 SMART
ZnF_C2H2 433 455 7.26e-3 SMART
ZnF_C2H2 461 483 6.42e-4 SMART
ZnF_C2H2 489 511 2.91e-2 SMART
ZnF_C2H2 517 539 9.73e-4 SMART
ZnF_C2H2 545 567 1.43e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196741
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700030K09Rik A T 8: 72,444,849 L33F probably benign Het
Actr8 T C 14: 29,990,970 probably null Het
Aldh16a1 C A 7: 45,141,967 A105S probably damaging Het
Angpt2 T C 8: 18,710,625 T154A probably benign Het
BC051665 A G 13: 60,782,704 V278A probably damaging Het
Cap1 T C 4: 122,860,187 T458A probably damaging Het
Clcn3 A T 8: 60,934,598 S179T probably damaging Het
Cyp2a22 T C 7: 26,933,553 D408G probably benign Het
D430042O09Rik T A 7: 125,870,685 V1442D probably damaging Het
Fam217b T A 2: 178,421,150 S302R probably damaging Het
Fcho2 A T 13: 98,789,807 D89E probably benign Het
Fnip1 C T 11: 54,499,508 R434C probably damaging Het
Gga3 G A 11: 115,589,102 T261M probably damaging Het
Gm21985 T C 2: 112,339,396 F292L probably damaging Het
Gm43638 A T 5: 87,486,215 S178T possibly damaging Het
Igkv10-95 G A 6: 68,680,764 G68E probably damaging Het
Lpcat2 G A 8: 92,871,147 R180Q possibly damaging Het
Muc6 C T 7: 141,638,614 A1984T possibly damaging Het
Npy4r T A 14: 34,146,365 Y322F probably damaging Het
Nwd2 T A 5: 63,805,594 H840Q probably damaging Het
Olfr844 G A 9: 19,319,233 G233D probably damaging Het
Osbpl2 G T 2: 180,145,194 probably benign Het
Pclo T A 5: 14,678,516 probably benign Het
Pold4 T C 19: 4,232,867 probably benign Het
Ppp1r16a A G 15: 76,694,294 probably benign Het
Pprc1 C T 19: 46,065,232 probably benign Het
Prkcg A G 7: 3,319,619 D343G probably benign Het
Scaf11 A C 15: 96,419,126 S852R probably benign Het
Slc31a2 C T 4: 62,292,696 T22I probably damaging Het
Sox30 T A 11: 45,981,342 D341E probably damaging Het
Tle4 A G 19: 14,465,340 S339P probably benign Het
Tsg101 A T 7: 46,908,925 Y78N probably damaging Het
Ttc1 T A 11: 43,738,803 S179C probably damaging Het
Txnrd3 T A 6: 89,654,147 S142T probably benign Het
Ubr4 C A 4: 139,412,736 A1210E probably damaging Het
Uroc1 C A 6: 90,338,653 P172Q probably damaging Het
Usp12 T C 5: 146,754,440 D168G probably benign Het
Vmn1r32 T A 6: 66,552,932 M287L probably benign Het
Vwa8 C T 14: 79,182,988 Q1710* probably null Het
Wdfy4 T A 14: 33,104,037 Q1219L probably damaging Het
Zbtb17 A G 4: 141,463,305 T145A probably benign Het
Other mutations in Zfp697
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02313:Zfp697 APN 3 98425450 missense probably benign 0.01
IGL03055:Zfp697 UTSW 3 98425494 missense possibly damaging 0.51
R0724:Zfp697 UTSW 3 98428166 missense probably damaging 1.00
R2165:Zfp697 UTSW 3 98428014 missense unknown
R2971:Zfp697 UTSW 3 98428301 missense probably damaging 1.00
R5749:Zfp697 UTSW 3 98425464 missense probably benign
R5954:Zfp697 UTSW 3 98428593 missense probably damaging 0.99
R6253:Zfp697 UTSW 3 98427539 missense possibly damaging 0.95
Posted On2013-11-11