Incidental Mutation 'IGL01451:Treml4'
ID84651
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Treml4
Ensembl Gene ENSMUSG00000051682
Gene Nametriggering receptor expressed on myeloid cells-like 4
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.125) question?
Stock #IGL01451
Quality Score
Status
Chromosome17
Chromosomal Location48264295-48275360 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to C at 48264995 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000118772 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059873] [ENSMUST00000125426] [ENSMUST00000136272] [ENSMUST00000153420] [ENSMUST00000154335]
Predicted Effect probably benign
Transcript: ENSMUST00000059873
SMART Domains Protein: ENSMUSP00000054121
Gene: ENSMUSG00000051682

DomainStartEndE-ValueType
low complexity region 7 18 N/A INTRINSIC
IG 32 137 6.51e-3 SMART
transmembrane domain 200 222 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000125426
SMART Domains Protein: ENSMUSP00000119177
Gene: ENSMUSG00000051682

DomainStartEndE-ValueType
low complexity region 7 18 N/A INTRINSIC
IG 28 133 6.51e-3 SMART
transmembrane domain 196 218 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000136272
SMART Domains Protein: ENSMUSP00000120550
Gene: ENSMUSG00000051682

DomainStartEndE-ValueType
low complexity region 7 18 N/A INTRINSIC
IG 32 137 6.51e-3 SMART
transmembrane domain 192 214 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000153420
SMART Domains Protein: ENSMUSP00000115290
Gene: ENSMUSG00000051682

DomainStartEndE-ValueType
low complexity region 7 18 N/A INTRINSIC
IG 32 137 6.51e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000154335
SMART Domains Protein: ENSMUSP00000118772
Gene: ENSMUSG00000051682

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
IG 32 137 6.51e-3 SMART
transmembrane domain 201 223 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele do not exhibit any significant alterations in the uptake and cross-presentation of dying cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700003H04Rik A G 3: 124,579,878 S23P possibly damaging Het
Adam1a T C 5: 121,519,376 Y618C probably benign Het
Amigo2 A C 15: 97,245,226 S438R probably benign Het
Atp5k T C 5: 108,434,056 I21V probably benign Het
Dnah2 T C 11: 69,474,191 probably benign Het
Dock2 A G 11: 34,310,390 Y984H probably damaging Het
Dpysl2 T A 14: 66,807,918 I469F possibly damaging Het
Edem3 C T 1: 151,818,628 T886I probably benign Het
Gart T C 16: 91,625,512 T706A probably benign Het
Gfpt2 A T 11: 49,807,690 probably benign Het
Gm11541 T G 11: 94,695,669 D84A unknown Het
Gne T C 4: 44,041,860 probably null Het
Gria4 A T 9: 4,503,652 D321E probably benign Het
Ift122 T G 6: 115,912,604 probably null Het
Lcp2 A T 11: 34,047,345 probably benign Het
Mcm2 C T 6: 88,891,966 probably benign Het
Olfr921 A G 9: 38,775,929 I225V probably benign Het
Ptpru C A 4: 131,769,492 probably benign Het
Rpap2 T C 5: 107,603,626 probably null Het
Slc25a39 T C 11: 102,404,900 T138A probably damaging Het
St6galnac1 A C 11: 116,769,339 S49R probably benign Het
Stat1 T C 1: 52,139,343 L312P probably damaging Het
Tmem198 T C 1: 75,484,370 probably benign Het
Top2a A T 11: 99,011,030 L458Q probably damaging Het
Trpm6 A G 19: 18,809,569 D503G probably damaging Het
Ttn C A 2: 76,945,273 E1854D unknown Het
Ubqln3 A T 7: 104,142,196 M229K possibly damaging Het
Zfyve9 T C 4: 108,682,260 T939A probably damaging Het
Other mutations in Treml4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01407:Treml4 APN 17 48264849 missense possibly damaging 0.82
IGL01787:Treml4 APN 17 48264704 missense probably damaging 1.00
R0027:Treml4 UTSW 17 48264934 missense possibly damaging 0.82
R1975:Treml4 UTSW 17 48272793 missense probably damaging 1.00
R4013:Treml4 UTSW 17 48264809 missense probably benign 0.09
R4327:Treml4 UTSW 17 48274389 missense probably damaging 0.98
R5586:Treml4 UTSW 17 48264899 missense probably damaging 1.00
R6220:Treml4 UTSW 17 48264848 missense possibly damaging 0.91
R6510:Treml4 UTSW 17 48274444 missense probably benign
R6964:Treml4 UTSW 17 48272819 critical splice donor site probably null
R8136:Treml4 UTSW 17 48264717 nonsense probably null
Posted On2013-11-11