Incidental Mutation 'IGL01452:Hdac11'
ID 84677
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Hdac11
Ensembl Gene ENSMUSG00000034245
Gene Name histone deacetylase 11
Synonyms
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.284) question?
Stock # IGL01452
Quality Score
Status
Chromosome 6
Chromosomal Location 91133652-91151674 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 91144843 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 157 (D157G)
Ref Sequence ENSEMBL: ENSMUSP00000043828 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041736] [ENSMUST00000143621] [ENSMUST00000204776]
AlphaFold Q91WA3
Predicted Effect probably damaging
Transcript: ENSMUST00000041736
AA Change: D157G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000043828
Gene: ENSMUSG00000034245
AA Change: D157G

DomainStartEndE-ValueType
Pfam:Hist_deacetyl 24 321 1e-51 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127768
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134154
Predicted Effect probably benign
Transcript: ENSMUST00000143621
SMART Domains Protein: ENSMUSP00000121624
Gene: ENSMUSG00000034245

DomainStartEndE-ValueType
Pfam:Hist_deacetyl 23 141 1.6e-8 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000155007
AA Change: T142A
SMART Domains Protein: ENSMUSP00000120923
Gene: ENSMUSG00000034245
AA Change: T142A

DomainStartEndE-ValueType
SCOP:d1c3pa_ 14 122 8e-16 SMART
low complexity region 124 140 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000204776
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]
PHENOTYPE: Mice homozygous for a knockout allele exhibit increased IL10 secretion from peritoneal elicited macrophages stimulated with LPS, more suppressive myeloid-derived suppressive cell population and enhanced tumor growth of injected tumor cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bltp1 T A 3: 37,050,457 (GRCm39) probably benign Het
Carmil3 A G 14: 55,733,515 (GRCm39) N344D probably damaging Het
Cd300ld2 G A 11: 114,903,428 (GRCm39) probably benign Het
Ddx19b A G 8: 111,747,620 (GRCm39) S105P probably damaging Het
Dpf3 C A 12: 83,316,263 (GRCm39) R336L probably benign Het
Ecpas A G 4: 58,836,181 (GRCm39) S720P probably damaging Het
Foxj3 T C 4: 119,478,825 (GRCm39) L427P unknown Het
Klk13 G T 7: 43,376,060 (GRCm39) R245L possibly damaging Het
Med25 C T 7: 44,532,255 (GRCm39) M367I possibly damaging Het
Mindy3 G A 2: 12,360,083 (GRCm39) probably benign Het
Mtf2 C T 5: 108,228,809 (GRCm39) P42S probably damaging Het
Muc5ac A T 7: 141,371,292 (GRCm39) L3269F probably benign Het
Or1j15 T A 2: 36,458,754 (GRCm39) L48H probably damaging Het
Pcnx2 A G 8: 126,564,771 (GRCm39) S1041P probably damaging Het
Pcnx4 G T 12: 72,621,174 (GRCm39) G998V possibly damaging Het
Ptprk G A 10: 28,450,913 (GRCm39) probably null Het
Scn9a A G 2: 66,357,416 (GRCm39) F951L probably damaging Het
Septin11 A C 5: 93,309,063 (GRCm39) K248Q possibly damaging Het
Src T A 2: 157,304,903 (GRCm39) Y151N probably damaging Het
Tbc1d32 A T 10: 56,091,176 (GRCm39) M119K possibly damaging Het
Tiparp G T 3: 65,460,030 (GRCm39) G442* probably null Het
Ttn A G 2: 76,656,475 (GRCm39) probably benign Het
Vmn2r4 A T 3: 64,313,816 (GRCm39) N388K probably damaging Het
Other mutations in Hdac11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01556:Hdac11 APN 6 91,150,162 (GRCm39) missense probably benign 0.00
IGL02159:Hdac11 APN 6 91,150,084 (GRCm39) missense probably damaging 0.99
IGL03082:Hdac11 APN 6 91,150,085 (GRCm39) missense probably damaging 1.00
IGL03046:Hdac11 UTSW 6 91,145,827 (GRCm39) missense probably benign 0.02
R1791:Hdac11 UTSW 6 91,145,806 (GRCm39) missense probably benign
R5771:Hdac11 UTSW 6 91,146,364 (GRCm39) splice site probably null
R5877:Hdac11 UTSW 6 91,134,524 (GRCm39) missense probably damaging 1.00
R5974:Hdac11 UTSW 6 91,150,196 (GRCm39) missense probably benign
R6803:Hdac11 UTSW 6 91,143,247 (GRCm39) missense probably damaging 0.97
R7483:Hdac11 UTSW 6 91,136,214 (GRCm39) missense probably damaging 0.99
R7786:Hdac11 UTSW 6 91,150,158 (GRCm39) nonsense probably null
R8259:Hdac11 UTSW 6 91,149,210 (GRCm39) missense probably damaging 1.00
R8990:Hdac11 UTSW 6 91,145,799 (GRCm39) nonsense probably null
R9681:Hdac11 UTSW 6 91,150,068 (GRCm39) missense probably benign 0.11
Z1177:Hdac11 UTSW 6 91,144,816 (GRCm39) missense possibly damaging 0.64
Posted On 2013-11-11