Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01453:Ppil6'

84697

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ppil6

Ensembl Gene

ENSMUSG00000078451

Gene Name

peptidylprolyl isomerase (cyclophilin)-like 6

Synonyms

2900084F20Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.120) question?

Stock #

IGL01453

Quality Score

Status

Chromosome

Chromosomal Location

41366435-41390282 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 41374473 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 118 (I118T)

Ref Sequence

ENSEMBL: ENSMUSP00000101146 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000105507]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000105507
AA Change: I118T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000101146
Gene: ENSMUSG00000078451
AA Change: I118T

Domain	Start	End	E-Value	Type
low complexity region	20	33	N/A	INTRINSIC
Pfam:Pro_isomerase	147	310	1.3e-41	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214145

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000215608

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	A	G	11: 9,353,834 (GRCm39)	T3719A	probably damaging	Het
Abcb5	A	G	12: 118,831,705 (GRCm39)	S1216P	probably damaging	Het
Abl1	A	G	2: 31,668,989 (GRCm39)	T104A	probably damaging	Het
Adgrg6	A	T	10: 14,296,202 (GRCm39)	M1066K	possibly damaging	Het
Armc1	T	C	3: 19,198,594 (GRCm39)	N122S	probably benign	Het
Fat1	C	T	8: 45,504,307 (GRCm39)	T4600M	probably damaging	Het
Hrh1	T	A	6: 114,458,123 (GRCm39)	I468N	probably damaging	Het
Krt34	A	T	11: 99,930,916 (GRCm39)	L162Q	probably damaging	Het
Macrod2	A	T	2: 140,294,492 (GRCm39)		probably benign	Het
Mfsd9	C	A	1: 40,829,638 (GRCm39)		probably benign	Het
Nap1l1	C	T	10: 111,328,839 (GRCm39)	T256I	probably benign	Het
Or12e1	A	G	2: 87,022,192 (GRCm39)	I54V	probably benign	Het
Or5h22	T	C	16: 58,895,132 (GRCm39)	I104V	probably benign	Het
Or6k4	A	G	1: 173,964,679 (GRCm39)	Y123C	possibly damaging	Het
Pard6a	T	A	8: 106,429,309 (GRCm39)		probably null	Het
Pmm2	G	A	16: 8,466,532 (GRCm39)	R119Q	probably damaging	Het
Por	C	T	5: 135,763,040 (GRCm39)	Q517*	probably null	Het
Psg26	A	G	7: 18,213,999 (GRCm39)	V221A	possibly damaging	Het
Ptpru	C	A	4: 131,496,803 (GRCm39)		probably benign	Het
Rpl27a	T	A	7: 109,118,832 (GRCm39)	V15E	probably benign	Het
Setd1b	T	C	5: 123,296,527 (GRCm39)		probably benign	Het
Slc17a1	A	G	13: 24,058,714 (GRCm39)	N56S	probably damaging	Het
Sybu	A	T	15: 44,536,201 (GRCm39)	D508E	probably damaging	Het
Tada2b	A	C	5: 36,633,686 (GRCm39)	N222K	probably damaging	Het
Tbcb	T	C	7: 29,930,627 (GRCm39)		probably null	Het
Tmprss11f	C	A	5: 86,692,691 (GRCm39)	G78*	probably null	Het
Vmn2r65	T	C	7: 84,589,708 (GRCm39)	Y736C	probably damaging	Het
Zc3h7a	G	A	16: 10,967,242 (GRCm39)	P517S	probably benign	Het
Zfp280d	A	G	9: 72,229,868 (GRCm39)	T392A	possibly damaging	Het
Zfp318	T	A	17: 46,719,942 (GRCm39)		probably null	Het

Other mutations in Ppil6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01110:Ppil6	APN	10	41,374,406 (GRCm39)	missense	probably benign	0.00
IGL02964:Ppil6	APN	10	41,383,479 (GRCm39)	missense	probably benign	0.13
R0827:Ppil6	UTSW	10	41,370,500 (GRCm39)	unclassified	probably benign
R1661:Ppil6	UTSW	10	41,390,176 (GRCm39)	missense	probably benign	0.03
R2302:Ppil6	UTSW	10	41,377,795 (GRCm39)	missense	probably damaging	1.00
R2844:Ppil6	UTSW	10	41,377,689 (GRCm39)	splice site	probably benign
R4258:Ppil6	UTSW	10	41,383,531 (GRCm39)	nonsense	probably null
R5098:Ppil6	UTSW	10	41,366,616 (GRCm39)	missense	probably null	1.00
R5455:Ppil6	UTSW	10	41,374,541 (GRCm39)	missense	probably benign	0.15
R5530:Ppil6	UTSW	10	41,383,494 (GRCm39)	missense	probably damaging	1.00
R6683:Ppil6	UTSW	10	41,374,427 (GRCm39)	missense	probably benign
R7288:Ppil6	UTSW	10	41,374,524 (GRCm39)	missense	probably benign	0.03
R7843:Ppil6	UTSW	10	41,377,862 (GRCm39)	missense	probably benign
R9424:Ppil6	UTSW	10	41,379,024 (GRCm39)	missense	probably damaging	1.00
R9590:Ppil6	UTSW	10	41,366,478 (GRCm39)	start codon destroyed	probably null	0.95
R9630:Ppil6	UTSW	10	41,370,550 (GRCm39)	missense	probably benign	0.26

Posted On

2013-11-11