Incidental Mutation 'IGL01454:Vmn2r4'
ID 84713
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r4
Ensembl Gene ENSMUSG00000092049
Gene Name vomeronasal 2, receptor 4
Synonyms EG637053
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # IGL01454
Quality Score
Status
Chromosome 3
Chromosomal Location 64295982-64322741 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 64313816 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 388 (N388K)
Ref Sequence ENSEMBL: ENSMUSP00000135228 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170280] [ENSMUST00000175724]
AlphaFold K7N784
Predicted Effect probably damaging
Transcript: ENSMUST00000170280
AA Change: N299K

PolyPhen 2 Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000127513
Gene: ENSMUSG00000092049
AA Change: N299K

DomainStartEndE-ValueType
Pfam:ANF_receptor 1 416 2.7e-72 PFAM
Pfam:Peripla_BP_6 61 240 1.9e-9 PFAM
Pfam:NCD3G 458 511 1.1e-17 PFAM
Pfam:7tm_3 542 779 1.8e-75 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000175724
AA Change: N388K

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000135228
Gene: ENSMUSG00000092049
AA Change: N388K

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 88 505 2.3e-75 PFAM
Pfam:NCD3G 547 600 4.7e-17 PFAM
Pfam:7tm_3 633 867 8.2e-47 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 17 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap25 G A 6: 87,473,058 (GRCm39) A33V possibly damaging Het
BC004004 T C 17: 29,512,995 (GRCm39) S140P possibly damaging Het
Cul3 T C 1: 80,281,900 (GRCm39) D26G probably damaging Het
Dnah17 A T 11: 117,949,223 (GRCm39) F2929I probably damaging Het
Gm21560 A G 14: 6,216,286 (GRCm38) F186L probably benign Het
Krt32 C T 11: 99,974,907 (GRCm39) E347K probably damaging Het
Mtarc1 A G 1: 184,539,377 (GRCm39) L98P probably damaging Het
Myh8 T C 11: 67,174,422 (GRCm39) I223T probably damaging Het
Nr4a3 T A 4: 48,067,803 (GRCm39) D466E probably damaging Het
Plxnb1 A T 9: 108,942,422 (GRCm39) D1757V probably damaging Het
Pnpt1 T C 11: 29,087,142 (GRCm39) I167T probably benign Het
Polrmt T C 10: 79,579,517 (GRCm39) E78G possibly damaging Het
Pparg A G 6: 115,416,900 (GRCm39) D31G probably damaging Het
Tiparp G T 3: 65,460,030 (GRCm39) G442* probably null Het
Trio T C 15: 27,833,071 (GRCm39) I104V probably benign Het
Vgll4 A G 6: 114,840,957 (GRCm39) V113A probably benign Het
Zscan20 T C 4: 128,483,334 (GRCm39) E445G probably benign Het
Other mutations in Vmn2r4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01310:Vmn2r4 APN 3 64,317,200 (GRCm39) splice site probably null
IGL01448:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01452:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01456:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01463:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01467:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01468:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01470:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01476:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01481:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01534:Vmn2r4 APN 3 64,313,844 (GRCm39) missense probably damaging 1.00
IGL01636:Vmn2r4 APN 3 64,313,657 (GRCm39) missense probably benign 0.21
IGL01879:Vmn2r4 APN 3 64,298,431 (GRCm39) missense probably damaging 1.00
IGL02147:Vmn2r4 APN 3 64,305,782 (GRCm39) splice site probably benign
IGL02276:Vmn2r4 APN 3 64,313,877 (GRCm39) missense possibly damaging 0.95
IGL02432:Vmn2r4 APN 3 64,313,821 (GRCm39) missense probably benign 0.38
IGL02533:Vmn2r4 APN 3 64,305,840 (GRCm39) nonsense probably null
IGL02655:Vmn2r4 APN 3 64,305,886 (GRCm39) missense probably damaging 0.97
IGL02666:Vmn2r4 APN 3 64,296,433 (GRCm39) missense probably benign 0.10
IGL02902:Vmn2r4 APN 3 64,314,337 (GRCm39) missense probably benign 0.22
IGL03189:Vmn2r4 APN 3 64,296,589 (GRCm39) missense possibly damaging 0.89
IGL03250:Vmn2r4 APN 3 64,314,063 (GRCm39) missense probably damaging 1.00
IGL03271:Vmn2r4 APN 3 64,305,850 (GRCm39) missense probably benign 0.01
R0310:Vmn2r4 UTSW 3 64,296,855 (GRCm39) nonsense probably null
R0504:Vmn2r4 UTSW 3 64,296,784 (GRCm39) missense probably damaging 1.00
R1546:Vmn2r4 UTSW 3 64,314,309 (GRCm39) missense probably damaging 1.00
R1562:Vmn2r4 UTSW 3 64,296,865 (GRCm39) missense probably damaging 0.98
R1863:Vmn2r4 UTSW 3 64,314,410 (GRCm39) missense probably benign 0.33
R1873:Vmn2r4 UTSW 3 64,298,479 (GRCm39) missense possibly damaging 0.93
R1939:Vmn2r4 UTSW 3 64,305,976 (GRCm39) missense probably benign 0.00
R2103:Vmn2r4 UTSW 3 64,322,704 (GRCm39) missense possibly damaging 0.48
R3083:Vmn2r4 UTSW 3 64,296,788 (GRCm39) missense probably damaging 1.00
R3687:Vmn2r4 UTSW 3 64,296,896 (GRCm39) missense possibly damaging 0.93
R3707:Vmn2r4 UTSW 3 64,296,895 (GRCm39) missense probably damaging 0.99
R3963:Vmn2r4 UTSW 3 64,322,572 (GRCm39) missense probably damaging 0.99
R4428:Vmn2r4 UTSW 3 64,322,590 (GRCm39) missense probably damaging 1.00
R4710:Vmn2r4 UTSW 3 64,317,201 (GRCm39) critical splice donor site probably null
R4737:Vmn2r4 UTSW 3 64,317,384 (GRCm39) missense probably damaging 1.00
R4767:Vmn2r4 UTSW 3 64,298,397 (GRCm39) missense probably damaging 0.99
R4776:Vmn2r4 UTSW 3 64,296,082 (GRCm39) missense probably damaging 0.96
R4834:Vmn2r4 UTSW 3 64,317,484 (GRCm39) missense probably benign 0.40
R4893:Vmn2r4 UTSW 3 64,313,676 (GRCm39) missense probably damaging 0.96
R4908:Vmn2r4 UTSW 3 64,296,476 (GRCm39) missense possibly damaging 0.59
R5049:Vmn2r4 UTSW 3 64,306,019 (GRCm39) splice site probably null
R5092:Vmn2r4 UTSW 3 64,298,373 (GRCm39) missense probably benign 0.01
R5234:Vmn2r4 UTSW 3 64,305,878 (GRCm39) missense possibly damaging 0.88
R5240:Vmn2r4 UTSW 3 64,314,358 (GRCm39) missense possibly damaging 0.53
R5704:Vmn2r4 UTSW 3 64,317,370 (GRCm39) missense probably benign 0.03
R5897:Vmn2r4 UTSW 3 64,322,687 (GRCm39) nonsense probably null
R5907:Vmn2r4 UTSW 3 64,298,487 (GRCm39) missense probably damaging 0.99
R5924:Vmn2r4 UTSW 3 64,296,685 (GRCm39) missense probably damaging 1.00
R6145:Vmn2r4 UTSW 3 64,314,364 (GRCm39) missense probably benign 0.00
R6191:Vmn2r4 UTSW 3 64,322,702 (GRCm39) missense probably benign 0.34
R6192:Vmn2r4 UTSW 3 64,322,699 (GRCm39) missense probably benign 0.00
R6207:Vmn2r4 UTSW 3 64,313,926 (GRCm39) missense probably damaging 1.00
R6457:Vmn2r4 UTSW 3 64,317,378 (GRCm39) missense probably damaging 1.00
R6533:Vmn2r4 UTSW 3 64,322,519 (GRCm39) missense probably benign
R6545:Vmn2r4 UTSW 3 64,313,777 (GRCm39) missense possibly damaging 0.50
R6594:Vmn2r4 UTSW 3 64,296,731 (GRCm39) missense probably damaging 1.00
R7049:Vmn2r4 UTSW 3 64,296,550 (GRCm39) missense probably benign 0.14
R7150:Vmn2r4 UTSW 3 64,305,898 (GRCm39) missense probably benign 0.01
R7187:Vmn2r4 UTSW 3 64,322,681 (GRCm39) missense probably benign 0.00
R7363:Vmn2r4 UTSW 3 64,314,432 (GRCm39) missense probably damaging 1.00
R7477:Vmn2r4 UTSW 3 64,305,850 (GRCm39) missense probably benign 0.01
R7675:Vmn2r4 UTSW 3 64,322,657 (GRCm39) missense probably benign 0.01
R7858:Vmn2r4 UTSW 3 64,317,226 (GRCm39) missense probably benign 0.00
R7888:Vmn2r4 UTSW 3 64,313,943 (GRCm39) missense probably damaging 0.99
R8678:Vmn2r4 UTSW 3 64,314,391 (GRCm39) missense probably benign
R8743:Vmn2r4 UTSW 3 64,317,247 (GRCm39) missense possibly damaging 0.95
R8841:Vmn2r4 UTSW 3 64,314,058 (GRCm39) missense probably damaging 0.97
R9671:Vmn2r4 UTSW 3 64,317,271 (GRCm39) missense probably benign 0.00
R9778:Vmn2r4 UTSW 3 64,322,497 (GRCm39) missense probably benign 0.15
X0019:Vmn2r4 UTSW 3 64,314,057 (GRCm39) missense probably damaging 0.99
Posted On 2013-11-11