Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01458:Psg18'

84862

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Psg18

Ensembl Gene

ENSMUSG00000003505

Gene Name

pregnancy specific glycoprotein 18

Synonyms

Cea-3, Cea3, mmCGM6

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

IGL01458

Quality Score

Status

Chromosome

Chromosomal Location

18345422-18355009 bp(-) (GRCm38)

Type of Mutation

start codon destroyed

DNA Base Change (assembly)

A to T at 18354816 bp

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 1 (M1K)

Ref Sequence

ENSEMBL: ENSMUSP00000003597 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000003597] [ENSMUST00000098783]

Predicted Effect

probably null
Transcript: ENSMUST00000003597
AA Change: M1K

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000003597
Gene: ENSMUSG00000003505
AA Change: M1K

Domain	Start	End	E-Value	Type
low complexity region	19	30	N/A	INTRINSIC
IG	40	140	2.11e-2	SMART
IG	161	262	1.03e0	SMART
IG	281	380	2.15e-3	SMART
IGc2	398	462	1.58e-10	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000098783
AA Change: M1K

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000096380
Gene: ENSMUSG00000003505
AA Change: M1K

Domain	Start	End	E-Value	Type
IG	40	141	1.03e0	SMART
IG	160	259	2.15e-3	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930433N12Rik	A	T	9: 3,134,008		noncoding transcript	Het
Akap12	A	G	10: 4,354,060	E290G	probably damaging	Het
Akap6	T	A	12: 52,886,818	C364*	probably null	Het
Akr1c18	A	T	13: 4,137,144	Y198N	probably damaging	Het
Aurka	T	C	2: 172,368,979		probably benign	Het
Bloc1s6	T	A	2: 122,744,215		probably null	Het
Clca1	C	T	3: 145,007,778	M697I	probably benign	Het
Csn2	T	C	5: 87,696,020		probably benign	Het
Dsc1	T	C	18: 20,099,138	E271G	probably damaging	Het
Evi5	G	A	5: 107,815,647	A354V	probably damaging	Het
Fcer2a	T	A	8: 3,688,151	R137S	probably benign	Het
Fto	A	G	8: 91,441,716	T266A	probably benign	Het
Fzd4	G	A	7: 89,404,735	V17I	unknown	Het
Gadd45b	T	C	10: 80,931,241	L105P	probably damaging	Het
Galntl6	T	C	8: 58,427,709	S137G	probably damaging	Het
Gm2022	A	T	12: 87,895,388	K7*	probably null	Het
Gm5771	T	G	6: 41,396,687	D161E	probably benign	Het
Gpr135	T	C	12: 72,069,668	M442V	probably benign	Het
Kcnq1	T	A	7: 143,194,278	Y330*	probably null	Het
Kdm5b	A	G	1: 134,621,986	R1106G	possibly damaging	Het
Lrrc8e	C	T	8: 4,236,141	R789W	probably damaging	Het
Myo16	T	C	8: 10,435,853	L644P	probably damaging	Het
Nbeal1	G	T	1: 60,242,625		probably null	Het
Nlrp4c	T	C	7: 6,100,784	C906R	possibly damaging	Het
Olfr1118	C	T	2: 87,309,482	T251I	probably damaging	Het
Olfr344	T	A	2: 36,568,742	L48H	probably damaging	Het
Olfr389	A	T	11: 73,776,706	I207N	probably benign	Het
Ovgp1	A	G	3: 105,974,991	N70D	probably benign	Het
Panx3	A	T	9: 37,661,147	M369K	probably damaging	Het
Plet1	A	G	9: 50,494,717	N52S	probably benign	Het
Ptprz1	A	T	6: 22,972,844	D251V	probably damaging	Het
Serpinb6a	A	G	13: 33,930,081	Y88H	possibly damaging	Het
Siglecf	G	A	7: 43,355,138	R297Q	possibly damaging	Het
Tbx15	T	C	3: 99,316,228	V244A	probably damaging	Het
Top2a	A	T	11: 99,011,030	L458Q	probably damaging	Het
Trim39	A	G	17: 36,263,963		probably benign	Het
Vps37c	T	C	19: 10,710,417	C81R	probably damaging	Het
Wdr62	A	T	7: 30,241,762	S744T	probably benign	Het
Zyg11a	G	A	4: 108,204,902	T234I	probably damaging	Het

Other mutations in Psg18

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01748:Psg18	APN	7	18353551	missense	probably benign	0.05
IGL01767:Psg18	APN	7	18353397	missense	possibly damaging	0.80
IGL02727:Psg18	APN	7	18345950	missense	probably damaging	1.00
IGL02744:Psg18	APN	7	18349402	missense	probably benign	0.38
PIT4466001:Psg18	UTSW	7	18349316	missense	probably benign	0.30
R0331:Psg18	UTSW	7	18353308	missense	probably benign	0.03
R1077:Psg18	UTSW	7	18351075	missense	possibly damaging	0.84
R1171:Psg18	UTSW	7	18346079	missense	probably benign	0.10
R1173:Psg18	UTSW	7	18354817	start codon destroyed	probably null	0.97
R1234:Psg18	UTSW	7	18349190	missense	probably damaging	1.00
R1553:Psg18	UTSW	7	18353481	missense	probably benign	0.19
R1632:Psg18	UTSW	7	18350899	missense	probably benign	0.02
R2108:Psg18	UTSW	7	18350874	missense	probably damaging	1.00
R2439:Psg18	UTSW	7	18346119	missense	probably benign	0.24
R3032:Psg18	UTSW	7	18350979	missense	probably benign	0.01
R3053:Psg18	UTSW	7	18349193	missense	probably damaging	1.00
R3432:Psg18	UTSW	7	18349171	missense	possibly damaging	0.61
R3725:Psg18	UTSW	7	18354823	start gained	probably benign
R4479:Psg18	UTSW	7	18350862	missense	probably benign	0.01
R4480:Psg18	UTSW	7	18350862	missense	probably benign	0.01
R4846:Psg18	UTSW	7	18350786	nonsense	probably null
R4858:Psg18	UTSW	7	18353484	missense	possibly damaging	0.49
R5010:Psg18	UTSW	7	18349354	missense	probably damaging	1.00
R5225:Psg18	UTSW	7	18345949	missense	probably damaging	1.00
R5450:Psg18	UTSW	7	18353425	missense	probably benign	0.32
R5526:Psg18	UTSW	7	18349348	missense	probably damaging	1.00
R5840:Psg18	UTSW	7	18346602	intron	probably benign
R6409:Psg18	UTSW	7	18353521	missense	probably benign
R7164:Psg18	UTSW	7	18350937	missense	possibly damaging	0.89
R7276:Psg18	UTSW	7	18345984	missense	probably damaging	0.99
R7768:Psg18	UTSW	7	18346028	missense	probably damaging	1.00
R8301:Psg18	UTSW	7	18353377	missense	probably damaging	0.99
Z1176:Psg18	UTSW	7	18354787	missense	probably benign	0.07
Z1177:Psg18	UTSW	7	18349115	missense	probably benign	0.30
Z1177:Psg18	UTSW	7	18349198	missense	probably benign	0.10

Posted On

2013-11-11