Incidental Mutation 'IGL01458:Plet1'
ID84879
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Plet1
Ensembl Gene ENSMUSG00000032068
Gene Nameplacenta expressed transcript 1
Synonyms1600029D21Rik, PLET1, 0610037B23Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01458
Quality Score
Status
Chromosome9
Chromosomal Location50494525-50505482 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 50494717 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Serine at position 52 (N52S)
Ref Sequence ENSEMBL: ENSMUSP00000139422 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114474] [ENSMUST00000188047]
Predicted Effect probably benign
Transcript: ENSMUST00000114474
AA Change: N52S

PolyPhen 2 Score 0.207 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000110118
Gene: ENSMUSG00000032068
AA Change: N52S

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
low complexity region 163 209 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000188047
AA Change: N52S

PolyPhen 2 Score 0.207 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000139422
Gene: ENSMUSG00000032068
AA Change: N52S

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000188703
Predicted Effect noncoding transcript
Transcript: ENSMUST00000190941
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930433N12Rik A T 9: 3,134,008 noncoding transcript Het
Akap12 A G 10: 4,354,060 E290G probably damaging Het
Akap6 T A 12: 52,886,818 C364* probably null Het
Akr1c18 A T 13: 4,137,144 Y198N probably damaging Het
Aurka T C 2: 172,368,979 probably benign Het
Bloc1s6 T A 2: 122,744,215 probably null Het
Clca1 C T 3: 145,007,778 M697I probably benign Het
Csn2 T C 5: 87,696,020 probably benign Het
Dsc1 T C 18: 20,099,138 E271G probably damaging Het
Evi5 G A 5: 107,815,647 A354V probably damaging Het
Fcer2a T A 8: 3,688,151 R137S probably benign Het
Fto A G 8: 91,441,716 T266A probably benign Het
Fzd4 G A 7: 89,404,735 V17I unknown Het
Gadd45b T C 10: 80,931,241 L105P probably damaging Het
Galntl6 T C 8: 58,427,709 S137G probably damaging Het
Gm2022 A T 12: 87,895,388 K7* probably null Het
Gm5771 T G 6: 41,396,687 D161E probably benign Het
Gpr135 T C 12: 72,069,668 M442V probably benign Het
Kcnq1 T A 7: 143,194,278 Y330* probably null Het
Kdm5b A G 1: 134,621,986 R1106G possibly damaging Het
Lrrc8e C T 8: 4,236,141 R789W probably damaging Het
Myo16 T C 8: 10,435,853 L644P probably damaging Het
Nbeal1 G T 1: 60,242,625 probably null Het
Nlrp4c T C 7: 6,100,784 C906R possibly damaging Het
Olfr1118 C T 2: 87,309,482 T251I probably damaging Het
Olfr344 T A 2: 36,568,742 L48H probably damaging Het
Olfr389 A T 11: 73,776,706 I207N probably benign Het
Ovgp1 A G 3: 105,974,991 N70D probably benign Het
Panx3 A T 9: 37,661,147 M369K probably damaging Het
Psg18 A T 7: 18,354,816 M1K probably null Het
Ptprz1 A T 6: 22,972,844 D251V probably damaging Het
Serpinb6a A G 13: 33,930,081 Y88H possibly damaging Het
Siglecf G A 7: 43,355,138 R297Q possibly damaging Het
Tbx15 T C 3: 99,316,228 V244A probably damaging Het
Top2a A T 11: 99,011,030 L458Q probably damaging Het
Trim39 A G 17: 36,263,963 probably benign Het
Vps37c T C 19: 10,710,417 C81R probably damaging Het
Wdr62 A T 7: 30,241,762 S744T probably benign Het
Zyg11a G A 4: 108,204,902 T234I probably damaging Het
Other mutations in Plet1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00949:Plet1 APN 9 50499223 missense possibly damaging 0.62
IGL02108:Plet1 APN 9 50499087 splice site probably benign
IGL03063:Plet1 APN 9 50504422 missense probably benign 0.00
R0012:Plet1 UTSW 9 50499130 missense probably benign 0.02
R1895:Plet1 UTSW 9 50504352 splice site probably null
R1946:Plet1 UTSW 9 50504352 splice site probably null
R5127:Plet1 UTSW 9 50504295 missense probably benign 0.16
R6352:Plet1 UTSW 9 50501107 missense probably damaging 0.99
Posted On2013-11-11