Incidental Mutation 'IGL00593:Trmo'
ID8489
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trmo
Ensembl Gene ENSMUSG00000028331
Gene NametRNA methyltransferase O
Synonyms5830415F09Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00593
Quality Score
Status
Chromosome4
Chromosomal Location46376505-46389437 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 46382490 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 209 (V209A)
Ref Sequence ENSEMBL: ENSMUSP00000119785 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030015] [ENSMUST00000086563] [ENSMUST00000151903]
Predicted Effect probably benign
Transcript: ENSMUST00000030015
AA Change: V202A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000030015
Gene: ENSMUSG00000028331
AA Change: V202A

DomainStartEndE-ValueType
Pfam:UPF0066 42 165 2.3e-45 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000086563
AA Change: V202A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000083752
Gene: ENSMUSG00000028331
AA Change: V202A

DomainStartEndE-ValueType
Pfam:UPF0066 44 164 1.2e-46 PFAM
low complexity region 431 442 N/A INTRINSIC
low complexity region 443 456 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000151903
AA Change: V209A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000119785
Gene: ENSMUSG00000028331
AA Change: V209A

DomainStartEndE-ValueType
Pfam:UPF0066 49 172 4.1e-45 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 15 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agtr2 A T X: 21,486,480 K118* probably null Het
Akap14 A T X: 37,150,831 H525Q possibly damaging Het
Crb1 T C 1: 139,323,245 I323V probably benign Het
H60b T C 10: 22,287,063 I179T possibly damaging Het
Krt34 A G 11: 100,038,694 probably benign Het
Mroh9 T C 1: 163,045,781 N541D possibly damaging Het
Plxnb1 A T 9: 109,113,868 I1841F probably benign Het
Ppp4r3b A G 11: 29,197,205 D3G possibly damaging Het
Rp1 T C 1: 4,345,403 T1829A possibly damaging Het
Ssx2ip T C 3: 146,436,552 F468L probably damaging Het
Togaram1 A G 12: 65,006,399 E1301G probably damaging Het
Tpd52l2 A T 2: 181,499,896 D24V probably damaging Het
Zfp141 A T 7: 42,475,307 C580* probably null Het
Zfp422 C A 6: 116,626,958 A27S probably benign Het
Zfp786 A T 6: 47,819,671 *778R probably null Het
Other mutations in Trmo
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01296:Trmo APN 4 46387589 missense probably damaging 1.00
IGL01308:Trmo APN 4 46377053 utr 3 prime probably benign
IGL01544:Trmo APN 4 46386169 missense probably damaging 1.00
IGL01545:Trmo APN 4 46386169 missense probably damaging 1.00
IGL01722:Trmo APN 4 46386092 critical splice donor site probably null
IGL02085:Trmo APN 4 46380217 missense probably damaging 1.00
IGL02927:Trmo APN 4 46387602 missense probably damaging 1.00
R0645:Trmo UTSW 4 46377083 utr 3 prime probably benign
R0745:Trmo UTSW 4 46382104 missense probably damaging 1.00
R1365:Trmo UTSW 4 46380278 missense probably damaging 1.00
R1835:Trmo UTSW 4 46380158 missense probably damaging 1.00
R3928:Trmo UTSW 4 46382647 missense probably damaging 1.00
R3929:Trmo UTSW 4 46382647 missense probably damaging 1.00
R4497:Trmo UTSW 4 46382140 missense probably damaging 1.00
R4938:Trmo UTSW 4 46382388 missense probably benign 0.00
R4980:Trmo UTSW 4 46389364 nonsense probably null
R5209:Trmo UTSW 4 46387740 missense probably damaging 0.99
R5639:Trmo UTSW 4 46382073 missense probably benign 0.00
R5855:Trmo UTSW 4 46382568 missense probably benign 0.43
R6151:Trmo UTSW 4 46389390 missense probably damaging 1.00
R7351:Trmo UTSW 4 46387716 missense possibly damaging 0.78
R8684:Trmo UTSW 4 46386251 nonsense probably null
R8684:Trmo UTSW 4 46386253 critical splice acceptor site probably null
R8823:Trmo UTSW 4 46382604 missense probably damaging 1.00
R8856:Trmo UTSW 4 46387625 missense probably benign 0.01
Posted On2012-12-06