Incidental Mutation 'R1087:Rnf169'
ID 85070
Institutional Source Beutler Lab
Gene Symbol Rnf169
Ensembl Gene ENSMUSG00000058761
Gene Name ring finger protein 169
Synonyms 2900057K09Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.155) question?
Stock # R1087 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 99569461-99629655 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 99592204 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 216 (R216G)
Ref Sequence ENSEMBL: ENSMUSP00000079631 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080817]
AlphaFold E9Q7F2
Predicted Effect probably benign
Transcript: ENSMUST00000080817
AA Change: R216G

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000079631
Gene: ENSMUSG00000058761
AA Change: R216G

DomainStartEndE-ValueType
low complexity region 2 27 N/A INTRINSIC
low complexity region 32 46 N/A INTRINSIC
RING 61 96 3.16e-1 SMART
Blast:RING 133 176 7e-8 BLAST
low complexity region 302 314 N/A INTRINSIC
low complexity region 649 661 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174264
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208954
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Anxa11 A G 14: 25,870,603 (GRCm39) M56V unknown Het
Arid4a G A 12: 71,122,112 (GRCm39) S509N probably benign Het
Atp8b3 T C 10: 80,356,017 (GRCm39) R1232G probably benign Het
Axdnd1 T A 1: 156,193,259 (GRCm39) M643L probably benign Het
Bsph1 A G 7: 13,206,106 (GRCm39) Y57C probably damaging Het
Car13 G A 3: 14,706,885 (GRCm39) W6* probably null Het
Ccdc192 T C 18: 57,863,870 (GRCm39) S225P probably damaging Het
Ccng2 T C 5: 93,421,303 (GRCm39) I271T probably benign Het
Ces1f T A 8: 93,984,923 (GRCm39) D468V probably damaging Het
Chil4 A G 3: 106,117,881 (GRCm39) Y130H probably benign Het
Clns1a T A 7: 97,354,862 (GRCm39) H69Q possibly damaging Het
Cnot11 T A 1: 39,579,139 (GRCm39) S335T probably benign Het
Dcaf11 A G 14: 55,806,581 (GRCm39) S461G probably damaging Het
Dlst G A 12: 85,179,413 (GRCm39) M417I probably damaging Het
Dock4 A C 12: 40,779,937 (GRCm39) I612L probably benign Het
Endod1 A G 9: 14,268,489 (GRCm39) V332A possibly damaging Het
F830045P16Rik T C 2: 129,314,639 (GRCm39) T213A possibly damaging Het
Gm5773 A T 3: 93,681,065 (GRCm39) I246F probably damaging Het
Gml2 T A 15: 74,695,946 (GRCm39) D113E possibly damaging Het
Grik1 T C 16: 87,803,265 (GRCm39) E309G probably benign Het
Hectd1 A T 12: 51,823,355 (GRCm39) I1013K probably damaging Het
Kcmf1 T C 6: 72,835,863 (GRCm39) E22G probably damaging Het
Kdm5b T A 1: 134,528,375 (GRCm39) C361S probably damaging Het
Kif21b T C 1: 136,090,561 (GRCm39) S1150P probably damaging Het
Man2b1 G A 8: 85,821,800 (GRCm39) V701M probably damaging Het
Marchf10 T C 11: 105,281,488 (GRCm39) R266G probably damaging Het
Milr1 A G 11: 106,645,848 (GRCm39) Y130C probably damaging Het
Nampt A G 12: 32,883,042 (GRCm39) T76A possibly damaging Het
Nek10 A G 14: 14,827,059 (GRCm38) N86D possibly damaging Het
Nms T G 1: 38,983,192 (GRCm39) probably null Het
Or10w1 T A 19: 13,632,376 (GRCm39) C194* probably null Het
Parp14 A G 16: 35,678,658 (GRCm39) S437P probably damaging Het
Pif1 A G 9: 65,496,377 (GRCm39) M226V probably benign Het
Rorb T C 19: 18,937,778 (GRCm39) K307R probably damaging Het
Scube2 T C 7: 109,430,882 (GRCm39) D439G probably damaging Het
Serpinb8 T C 1: 107,534,727 (GRCm39) V266A probably damaging Het
Strip2 A G 6: 29,927,633 (GRCm39) E226G probably damaging Het
Trim23 A G 13: 104,324,618 (GRCm39) D212G possibly damaging Het
Vmn1r172 T A 7: 23,359,673 (GRCm39) V186D possibly damaging Het
Vwde A T 6: 13,186,803 (GRCm39) C895S probably damaging Het
Zswim8 C A 14: 20,767,933 (GRCm39) probably null Het
Other mutations in Rnf169
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01476:Rnf169 APN 7 99,604,691 (GRCm39) missense probably damaging 1.00
IGL02344:Rnf169 APN 7 99,575,642 (GRCm39) missense probably damaging 1.00
IGL03066:Rnf169 APN 7 99,574,760 (GRCm39) missense possibly damaging 0.85
R0201:Rnf169 UTSW 7 99,575,210 (GRCm39) missense possibly damaging 0.85
R1289:Rnf169 UTSW 7 99,574,943 (GRCm39) missense probably benign 0.01
R1476:Rnf169 UTSW 7 99,574,535 (GRCm39) missense possibly damaging 0.72
R1912:Rnf169 UTSW 7 99,575,461 (GRCm39) missense probably damaging 1.00
R1964:Rnf169 UTSW 7 99,574,732 (GRCm39) missense probably damaging 1.00
R2057:Rnf169 UTSW 7 99,574,615 (GRCm39) missense probably damaging 1.00
R2342:Rnf169 UTSW 7 99,574,652 (GRCm39) missense possibly damaging 0.87
R4755:Rnf169 UTSW 7 99,574,930 (GRCm39) missense probably benign 0.01
R4801:Rnf169 UTSW 7 99,575,653 (GRCm39) missense probably damaging 1.00
R4802:Rnf169 UTSW 7 99,575,653 (GRCm39) missense probably damaging 1.00
R5391:Rnf169 UTSW 7 99,584,367 (GRCm39) critical splice donor site probably null
R5395:Rnf169 UTSW 7 99,584,367 (GRCm39) critical splice donor site probably null
R5643:Rnf169 UTSW 7 99,576,338 (GRCm39) missense possibly damaging 0.85
R5817:Rnf169 UTSW 7 99,574,976 (GRCm39) missense probably benign 0.02
R5952:Rnf169 UTSW 7 99,574,840 (GRCm39) missense probably damaging 1.00
R6009:Rnf169 UTSW 7 99,576,330 (GRCm39) missense possibly damaging 0.92
R6453:Rnf169 UTSW 7 99,584,434 (GRCm39) missense probably benign 0.01
R7238:Rnf169 UTSW 7 99,574,954 (GRCm39) missense probably benign 0.10
R7500:Rnf169 UTSW 7 99,629,445 (GRCm39) missense probably damaging 0.99
R8194:Rnf169 UTSW 7 99,575,651 (GRCm39) missense probably damaging 1.00
R9227:Rnf169 UTSW 7 99,574,699 (GRCm39) missense possibly damaging 0.82
R9469:Rnf169 UTSW 7 99,575,567 (GRCm39) missense possibly damaging 0.92
R9548:Rnf169 UTSW 7 99,574,690 (GRCm39) missense probably damaging 1.00
R9729:Rnf169 UTSW 7 99,575,477 (GRCm39) missense probably damaging 1.00
Z1177:Rnf169 UTSW 7 99,575,068 (GRCm39) missense not run
Predicted Primers PCR Primer
(F):5'- AGCTTCACTGCTCTTAGGCTGCAC -3'
(R):5'- TGCCGCTTGATCTGGTCTGTAAAG -3'

Sequencing Primer
(F):5'- ATGTGTGACCCACTGACCTG -3'
(R):5'- AGATGTTTTTAAGTCTAGGATTGCC -3'
Posted On 2013-11-18