Incidental Mutation 'R1087:Anxa11'
ID85088
Institutional Source Beutler Lab
Gene Symbol Anxa11
Ensembl Gene ENSMUSG00000021866
Gene Nameannexin A11
SynonymsA830099O17Rik, Anx11
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.124) question?
Stock #R1087 (G1)
Quality Score225
Status Not validated
Chromosome14
Chromosomal Location25842156-25886804 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 25870179 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Valine at position 56 (M56V)
Ref Sequence ENSEMBL: ENSMUSP00000107983 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022416] [ENSMUST00000112364]
Predicted Effect unknown
Transcript: ENSMUST00000022416
AA Change: M56V
SMART Domains Protein: ENSMUSP00000022416
Gene: ENSMUSG00000021866
AA Change: M56V

DomainStartEndE-ValueType
low complexity region 3 31 N/A INTRINSIC
low complexity region 73 175 N/A INTRINSIC
ANX 215 267 7.18e-25 SMART
ANX 287 339 7.57e-24 SMART
ANX 371 423 1.35e-20 SMART
ANX 446 498 1.89e-24 SMART
Predicted Effect unknown
Transcript: ENSMUST00000112364
AA Change: M56V
SMART Domains Protein: ENSMUSP00000107983
Gene: ENSMUSG00000021866
AA Change: M56V

DomainStartEndE-ValueType
low complexity region 3 31 N/A INTRINSIC
low complexity region 73 175 N/A INTRINSIC
ANX 215 267 7.18e-25 SMART
ANX 287 339 7.57e-24 SMART
Pfam:Annexin 357 392 1.2e-9 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124704
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133547
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184083
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, Dec 2015]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700011I03Rik T C 18: 57,730,798 S225P probably damaging Het
Arid4a G A 12: 71,075,338 S509N probably benign Het
Atp8b3 T C 10: 80,520,183 R1232G probably benign Het
Axdnd1 T A 1: 156,365,689 M643L probably benign Het
Bsph1 A G 7: 13,472,181 Y57C probably damaging Het
Car13 G A 3: 14,641,825 W6* probably null Het
Ccng2 T C 5: 93,273,444 I271T probably benign Het
Ces1f T A 8: 93,258,295 D468V probably damaging Het
Chil4 A G 3: 106,210,565 Y130H probably benign Het
Clns1a T A 7: 97,705,655 H69Q possibly damaging Het
Cnot11 T A 1: 39,540,058 S335T probably benign Het
Dcaf11 A G 14: 55,569,124 S461G probably damaging Het
Dlst G A 12: 85,132,639 M417I probably damaging Het
Dock4 A C 12: 40,729,938 I612L probably benign Het
Endod1 A G 9: 14,357,193 V332A possibly damaging Het
F830045P16Rik T C 2: 129,472,719 T213A possibly damaging Het
Gm5773 A T 3: 93,773,758 I246F probably damaging Het
Gml2 T A 15: 74,824,097 D113E possibly damaging Het
Grik1 T C 16: 88,006,377 E309G probably benign Het
Hectd1 A T 12: 51,776,572 I1013K probably damaging Het
Kcmf1 T C 6: 72,858,880 E22G probably damaging Het
Kdm5b T A 1: 134,600,637 C361S probably damaging Het
Kif21b T C 1: 136,162,823 S1150P probably damaging Het
Man2b1 G A 8: 85,095,171 V701M probably damaging Het
March10 T C 11: 105,390,662 R266G probably damaging Het
Milr1 A G 11: 106,755,022 Y130C probably damaging Het
Nampt A G 12: 32,833,043 T76A possibly damaging Het
Nek10 A G 14: 14,827,059 N86D possibly damaging Het
Nms T G 1: 38,944,111 probably null Het
Olfr1490 T A 19: 13,655,012 C194* probably null Het
Parp14 A G 16: 35,858,288 S437P probably damaging Het
Pif1 A G 9: 65,589,095 M226V probably benign Het
Rnf169 T C 7: 99,942,997 R216G probably benign Het
Rorb T C 19: 18,960,414 K307R probably damaging Het
Scube2 T C 7: 109,831,675 D439G probably damaging Het
Serpinb8 T C 1: 107,606,997 V266A probably damaging Het
Strip2 A G 6: 29,927,634 E226G probably damaging Het
Trim23 A G 13: 104,188,110 D212G possibly damaging Het
Vmn1r172 T A 7: 23,660,248 V186D possibly damaging Het
Vwde A T 6: 13,186,804 C895S probably damaging Het
Zswim8 C A 14: 20,717,865 probably null Het
Other mutations in Anxa11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02194:Anxa11 APN 14 25870129 missense unknown
twirl UTSW 14 25872734 missense unknown
R0597:Anxa11 UTSW 14 25874228 missense probably damaging 1.00
R0656:Anxa11 UTSW 14 25873997 missense probably damaging 1.00
R0717:Anxa11 UTSW 14 25874789 splice site probably null
R2207:Anxa11 UTSW 14 25874297 missense probably damaging 1.00
R5041:Anxa11 UTSW 14 25874764 nonsense probably null
R6298:Anxa11 UTSW 14 25872734 missense unknown
R6416:Anxa11 UTSW 14 25874270 missense possibly damaging 0.74
R6944:Anxa11 UTSW 14 25874752 missense probably damaging 0.99
R7389:Anxa11 UTSW 14 25872888 missense probably damaging 0.99
R7760:Anxa11 UTSW 14 25872827 nonsense probably null
R8881:Anxa11 UTSW 14 25874263 missense probably damaging 1.00
X0005:Anxa11 UTSW 14 25874290 missense probably benign 0.03
Z1177:Anxa11 UTSW 14 25870176 missense unknown
Predicted Primers PCR Primer
(F):5'- ATGGCTGTCACATGCTCAGCTC -3'
(R):5'- ACCTGAGAGACCTTCAGTGCCAAG -3'

Sequencing Primer
(F):5'- TGGTTATCACAGCAGCCC -3'
(R):5'- GACCTTCAGTGCCAAGAATCTC -3'
Posted On2013-11-18