Mutagenetix > Incidental Mutation

Incidental Mutation 'R1075:Csnka2ip'

85629

Institutional Source

Beutler Lab

Gene Symbol

Csnka2ip

Ensembl Gene

ENSMUSG00000068167

Gene Name

casein kinase 2, alpha prime interacting protein

Synonyms

Ckt2

MMRRC Submission

039161-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.138) question?

Stock #

R1075 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

64298173-64422694 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 64298310 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Stop codon at position 685 (K685*)

Ref Sequence

ENSEMBL: ENSMUSP00000147880 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089279] [ENSMUST00000209382]

AlphaFold

Q8CH19

Predicted Effect

probably null
Transcript: ENSMUST00000089279
AA Change: K241*

SMART Domains

Protein: ENSMUSP00000086692
Gene: ENSMUSG00000068167
AA Change: K241*

Domain	Start	End	E-Value	Type
low complexity region	164	182	N/A	INTRINSIC
low complexity region	186	201	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000209382
AA Change: K685*

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.2%
20x: 94.4%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankrd6	T	C	4: 32,822,232 (GRCm39)	H179R	probably damaging	Het
Apbb2	G	T	5: 66,460,021 (GRCm39)	P692Q	probably damaging	Het
Arhgap40	A	G	2: 158,391,567 (GRCm39)	N627D	possibly damaging	Het
Asns	G	A	6: 7,676,076 (GRCm39)	R465*	probably null	Het
Bdkrb1	G	A	12: 105,570,562 (GRCm39)	V43I	probably benign	Het
Bod1	T	C	11: 31,621,514 (GRCm39)	D63G	possibly damaging	Het
Ccdc39	T	C	3: 33,880,629 (GRCm39)	K446R	probably damaging	Het
Dennd5a	A	T	7: 109,517,808 (GRCm39)	D609E	probably benign	Het
Dhx34	G	C	7: 15,952,274 (GRCm39)	T117S	probably benign	Het
Dpp4	A	T	2: 62,182,630 (GRCm39)	D550E	probably benign	Het
Enah	C	T	1: 181,784,066 (GRCm39)	R81K	unknown	Het
Epha5	G	T	5: 84,298,254 (GRCm39)	A383E	probably damaging	Het
Epha5	C	T	5: 84,298,255 (GRCm39)	A383T	probably damaging	Het
Etnppl	A	T	3: 130,423,212 (GRCm39)	M298L	probably benign	Het
Fam81a	G	A	9: 70,017,556 (GRCm39)	R130*	probably null	Het
Fbxl3	A	C	14: 103,332,839 (GRCm39)	H46Q	probably benign	Het
Gal3st1	A	G	11: 3,948,509 (GRCm39)	I239V	possibly damaging	Het
H2-T15	C	T	17: 36,367,038 (GRCm39)	G335D	probably benign	Het
Htra4	T	C	8: 25,523,612 (GRCm39)	I318V	probably benign	Het
Igdcc4	A	G	9: 65,038,932 (GRCm39)	T906A	possibly damaging	Het
Il7r	T	C	15: 9,516,543 (GRCm39)	N86S	probably benign	Het
Mettl17	A	G	14: 52,127,063 (GRCm39)	N231D	probably benign	Het
Mki67	T	C	7: 135,299,040 (GRCm39)	D1998G	probably benign	Het
Myh15	G	T	16: 48,940,417 (GRCm39)	R789L	possibly damaging	Het
Myh7	A	G	14: 55,224,860 (GRCm39)	V569A	probably benign	Het
Nell1	A	G	7: 50,503,588 (GRCm39)	I617M	probably damaging	Het
Nlrp1b	C	G	11: 71,072,512 (GRCm39)	E444Q	probably benign	Het
Or10ak16	T	C	4: 118,750,402 (GRCm39)	S41P	probably damaging	Het
Or2b4	T	A	17: 38,116,660 (GRCm39)	L208*	probably null	Het
Or2y8	T	A	11: 52,035,677 (GRCm39)	I227F	possibly damaging	Het
Psmd2	T	C	16: 20,478,709 (GRCm39)	S603P	probably damaging	Het
Slc4a2	T	A	5: 24,644,055 (GRCm39)	I913N	possibly damaging	Het
Smyd4	T	C	11: 75,291,164 (GRCm39)	Y589H	probably damaging	Het
Spag17	A	G	3: 100,000,992 (GRCm39)	E1850G	probably damaging	Het
Srsf11	A	T	3: 157,718,427 (GRCm39)		probably benign	Het
Stra6	A	T	9: 58,058,687 (GRCm39)	N488I	possibly damaging	Het
Supt20	C	T	3: 54,614,362 (GRCm39)	Q160*	probably null	Het
Tbc1d2b	G	A	9: 90,104,393 (GRCm39)	P583L	possibly damaging	Het
Uchl1	T	A	5: 66,839,808 (GRCm39)	F117I	probably damaging	Het
Usf1	T	A	1: 171,245,677 (GRCm39)	N307K	probably benign	Het
Zfp994	T	A	17: 22,419,926 (GRCm39)	H341L	probably damaging	Het

Other mutations in Csnka2ip

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02039:Csnka2ip	APN	16	64,298,957 (GRCm39)	missense	probably damaging	0.99
IGL02677:Csnka2ip	APN	16	64,298,675 (GRCm39)	missense	probably damaging	0.99
G1Funyon:Csnka2ip	UTSW	16	64,299,354 (GRCm39)	missense	unknown
R0593:Csnka2ip	UTSW	16	64,298,975 (GRCm39)	missense	probably damaging	0.99
R1698:Csnka2ip	UTSW	16	64,298,422 (GRCm39)	nonsense	probably null
R1815:Csnka2ip	UTSW	16	64,298,855 (GRCm39)	missense	probably benign
R6446:Csnka2ip	UTSW	16	64,299,744 (GRCm39)	nonsense	probably null
R6709:Csnka2ip	UTSW	16	64,298,932 (GRCm39)	missense	possibly damaging	0.92
R6937:Csnka2ip	UTSW	16	64,299,058 (GRCm39)	utr 5 prime	probably benign
R6999:Csnka2ip	UTSW	16	64,298,933 (GRCm39)	missense	unknown
R7013:Csnka2ip	UTSW	16	64,298,780 (GRCm39)	missense	unknown
R7103:Csnka2ip	UTSW	16	64,299,120 (GRCm39)	missense	unknown
R7395:Csnka2ip	UTSW	16	64,299,803 (GRCm39)	missense
R7816:Csnka2ip	UTSW	16	64,299,852 (GRCm39)	unclassified	probably benign
R8301:Csnka2ip	UTSW	16	64,299,354 (GRCm39)	missense	unknown
R8416:Csnka2ip	UTSW	16	64,300,295 (GRCm39)	missense
R8946:Csnka2ip	UTSW	16	64,300,667 (GRCm39)	splice site	probably benign
R9203:Csnka2ip	UTSW	16	64,298,630 (GRCm39)	missense	unknown
R9479:Csnka2ip	UTSW	16	64,298,262 (GRCm39)	missense	unknown
R9774:Csnka2ip	UTSW	16	64,299,093 (GRCm39)	missense	unknown
R9799:Csnka2ip	UTSW	16	64,298,672 (GRCm39)	missense	unknown

Predicted Primers

PCR Primer
(F):5'- TCCTTGAGCAGATGCTTTGCCAG -3'
(R):5'- AGCCAAGAGCCCCAGTCTATTGAC -3'

Sequencing Primer
(F):5'- GCAGATGCTTTGCCAGCTAATATAC -3'
(R):5'- tcctcctcctcttcttcctc -3'

Posted On

2013-11-18