Incidental Mutation 'R1076:Lypd10'
ID 85650
Institutional Source Beutler Lab
Gene Symbol Lypd10
Ensembl Gene ENSMUSG00000045587
Gene Name Ly6/PLAUR domain containing 10
Synonyms BC049730
MMRRC Submission 039162-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R1076 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 24408667-24413960 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 24413167 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Arginine at position 162 (K162R)
Ref Sequence ENSEMBL: ENSMUSP00000053275 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051714] [ENSMUST00000205376] [ENSMUST00000206826]
AlphaFold Q810N3
Predicted Effect probably benign
Transcript: ENSMUST00000051714
AA Change: K162R

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000053275
Gene: ENSMUSG00000045587
AA Change: K162R

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:UPAR_LY6 141 219 3.5e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205376
Predicted Effect probably benign
Transcript: ENSMUST00000206826
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.4%
  • 20x: 95.1%
Validation Efficiency 100% (39/39)
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ang4 T C 14: 52,001,759 (GRCm39) K63R probably damaging Het
Ankrd50 T C 3: 38,509,071 (GRCm39) N176D probably damaging Het
Apbb1 A T 7: 105,223,062 (GRCm39) L183Q probably benign Het
Cdh17 T C 4: 11,795,581 (GRCm39) V387A probably benign Het
Cldn4 A G 5: 134,975,191 (GRCm39) S137P probably damaging Het
Cnn1 A T 9: 22,019,165 (GRCm39) Q157L probably damaging Het
Csn1s1 A T 5: 87,824,242 (GRCm39) probably null Het
Dennd3 C T 15: 73,412,582 (GRCm39) H415Y probably damaging Het
Dnpep A G 1: 75,292,582 (GRCm39) probably benign Het
Dram1 C A 10: 88,161,246 (GRCm39) V208L probably damaging Het
Elovl2 A G 13: 41,343,583 (GRCm39) V115A possibly damaging Het
Fryl C T 5: 73,282,016 (GRCm39) probably benign Het
Gsap A G 5: 21,492,692 (GRCm39) T707A possibly damaging Het
Hsh2d G A 8: 72,954,304 (GRCm39) D229N probably benign Het
Ktn1 T A 14: 47,932,095 (GRCm39) M674K probably damaging Het
Larp4 A G 15: 99,895,311 (GRCm39) T295A probably benign Het
Lrp1 T C 10: 127,399,666 (GRCm39) probably benign Het
Macf1 T C 4: 123,279,391 (GRCm39) D3870G probably damaging Het
Mctp2 T G 7: 71,835,615 (GRCm39) probably null Het
Nbn A T 4: 15,970,719 (GRCm39) probably null Het
Neb A G 2: 52,094,904 (GRCm39) Y4883H probably damaging Het
Nsun6 A T 2: 15,014,283 (GRCm39) C286S probably benign Het
Pabpc4 T A 4: 123,186,701 (GRCm39) D307E possibly damaging Het
Pik3cg G A 12: 32,245,713 (GRCm39) probably benign Het
Ptpdc1 C T 13: 48,740,286 (GRCm39) E382K probably damaging Het
Serpina3k A G 12: 104,307,253 (GRCm39) T162A probably benign Het
Sis T C 3: 72,841,431 (GRCm39) T795A probably damaging Het
Skint8 T A 4: 111,784,416 (GRCm39) V14E probably damaging Het
Slc2a1 T G 4: 118,991,645 (GRCm39) M351R probably damaging Het
Slc41a3 G A 6: 90,621,142 (GRCm39) C394Y probably benign Het
Srp54b T C 12: 55,302,313 (GRCm39) probably benign Het
Ulk2 G A 11: 61,710,135 (GRCm39) H358Y probably damaging Het
Utp20 A T 10: 88,608,405 (GRCm39) I1544N possibly damaging Het
Utp20 A G 10: 88,608,321 (GRCm39) M1572T probably benign Het
Zbtb14 C A 17: 69,695,497 (GRCm39) F398L probably damaging Het
Other mutations in Lypd10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00847:Lypd10 APN 7 24,413,673 (GRCm39) missense probably benign 0.01
IGL01353:Lypd10 APN 7 24,413,662 (GRCm39) missense probably damaging 0.98
IGL01603:Lypd10 APN 7 24,411,954 (GRCm39) missense probably damaging 1.00
IGL03084:Lypd10 APN 7 24,413,605 (GRCm39) missense possibly damaging 0.80
R0453:Lypd10 UTSW 7 24,413,712 (GRCm39) missense probably benign 0.18
R0657:Lypd10 UTSW 7 24,412,872 (GRCm39) missense probably benign 0.00
R0946:Lypd10 UTSW 7 24,413,167 (GRCm39) missense probably benign 0.00
R1081:Lypd10 UTSW 7 24,412,967 (GRCm39) splice site probably null
R1926:Lypd10 UTSW 7 24,413,541 (GRCm39) missense probably damaging 1.00
R2571:Lypd10 UTSW 7 24,412,819 (GRCm39) missense probably benign 0.27
R3014:Lypd10 UTSW 7 24,412,821 (GRCm39) missense possibly damaging 0.93
R3832:Lypd10 UTSW 7 24,413,712 (GRCm39) missense probably benign 0.18
R4197:Lypd10 UTSW 7 24,413,119 (GRCm39) missense probably benign 0.01
R4705:Lypd10 UTSW 7 24,412,934 (GRCm39) missense probably damaging 0.99
R5609:Lypd10 UTSW 7 24,413,711 (GRCm39) missense possibly damaging 0.53
R6166:Lypd10 UTSW 7 24,413,644 (GRCm39) missense probably benign 0.00
R6385:Lypd10 UTSW 7 24,413,535 (GRCm39) missense probably damaging 0.97
R7477:Lypd10 UTSW 7 24,413,673 (GRCm39) missense probably benign 0.01
R8022:Lypd10 UTSW 7 24,413,599 (GRCm39) missense possibly damaging 0.92
R8169:Lypd10 UTSW 7 24,412,000 (GRCm39) missense probably benign 0.15
R8695:Lypd10 UTSW 7 24,413,203 (GRCm39) missense probably benign 0.16
R9129:Lypd10 UTSW 7 24,413,170 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AGCACCAAGGTCCTACTTGACCTC -3'
(R):5'- ACACCCAGGGTTATACTCTCCAGC -3'

Sequencing Primer
(F):5'- AAGCTTTCAGGTATGTGACCC -3'
(R):5'- GGGTTATACTCTCCAGCCACAC -3'
Posted On 2013-11-18