Incidental Mutation 'R1076:Lypd10'
ID |
85650 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Lypd10
|
Ensembl Gene |
ENSMUSG00000045587 |
Gene Name |
Ly6/PLAUR domain containing 10 |
Synonyms |
BC049730 |
MMRRC Submission |
039162-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.059)
|
Stock # |
R1076 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
24408667-24413960 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 24413167 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Lysine to Arginine
at position 162
(K162R)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000053275
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000051714]
[ENSMUST00000205376]
[ENSMUST00000206826]
|
AlphaFold |
Q810N3 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000051714
AA Change: K162R
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
SMART Domains |
Protein: ENSMUSP00000053275 Gene: ENSMUSG00000045587 AA Change: K162R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
Pfam:UPAR_LY6
|
141 |
219 |
3.5e-12 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000205376
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000206826
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.8%
- 10x: 97.4%
- 20x: 95.1%
|
Validation Efficiency |
100% (39/39) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 35 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Ang4 |
T |
C |
14: 52,001,759 (GRCm39) |
K63R |
probably damaging |
Het |
Ankrd50 |
T |
C |
3: 38,509,071 (GRCm39) |
N176D |
probably damaging |
Het |
Apbb1 |
A |
T |
7: 105,223,062 (GRCm39) |
L183Q |
probably benign |
Het |
Cdh17 |
T |
C |
4: 11,795,581 (GRCm39) |
V387A |
probably benign |
Het |
Cldn4 |
A |
G |
5: 134,975,191 (GRCm39) |
S137P |
probably damaging |
Het |
Cnn1 |
A |
T |
9: 22,019,165 (GRCm39) |
Q157L |
probably damaging |
Het |
Csn1s1 |
A |
T |
5: 87,824,242 (GRCm39) |
|
probably null |
Het |
Dennd3 |
C |
T |
15: 73,412,582 (GRCm39) |
H415Y |
probably damaging |
Het |
Dnpep |
A |
G |
1: 75,292,582 (GRCm39) |
|
probably benign |
Het |
Dram1 |
C |
A |
10: 88,161,246 (GRCm39) |
V208L |
probably damaging |
Het |
Elovl2 |
A |
G |
13: 41,343,583 (GRCm39) |
V115A |
possibly damaging |
Het |
Fryl |
C |
T |
5: 73,282,016 (GRCm39) |
|
probably benign |
Het |
Gsap |
A |
G |
5: 21,492,692 (GRCm39) |
T707A |
possibly damaging |
Het |
Hsh2d |
G |
A |
8: 72,954,304 (GRCm39) |
D229N |
probably benign |
Het |
Ktn1 |
T |
A |
14: 47,932,095 (GRCm39) |
M674K |
probably damaging |
Het |
Larp4 |
A |
G |
15: 99,895,311 (GRCm39) |
T295A |
probably benign |
Het |
Lrp1 |
T |
C |
10: 127,399,666 (GRCm39) |
|
probably benign |
Het |
Macf1 |
T |
C |
4: 123,279,391 (GRCm39) |
D3870G |
probably damaging |
Het |
Mctp2 |
T |
G |
7: 71,835,615 (GRCm39) |
|
probably null |
Het |
Nbn |
A |
T |
4: 15,970,719 (GRCm39) |
|
probably null |
Het |
Neb |
A |
G |
2: 52,094,904 (GRCm39) |
Y4883H |
probably damaging |
Het |
Nsun6 |
A |
T |
2: 15,014,283 (GRCm39) |
C286S |
probably benign |
Het |
Pabpc4 |
T |
A |
4: 123,186,701 (GRCm39) |
D307E |
possibly damaging |
Het |
Pik3cg |
G |
A |
12: 32,245,713 (GRCm39) |
|
probably benign |
Het |
Ptpdc1 |
C |
T |
13: 48,740,286 (GRCm39) |
E382K |
probably damaging |
Het |
Serpina3k |
A |
G |
12: 104,307,253 (GRCm39) |
T162A |
probably benign |
Het |
Sis |
T |
C |
3: 72,841,431 (GRCm39) |
T795A |
probably damaging |
Het |
Skint8 |
T |
A |
4: 111,784,416 (GRCm39) |
V14E |
probably damaging |
Het |
Slc2a1 |
T |
G |
4: 118,991,645 (GRCm39) |
M351R |
probably damaging |
Het |
Slc41a3 |
G |
A |
6: 90,621,142 (GRCm39) |
C394Y |
probably benign |
Het |
Srp54b |
T |
C |
12: 55,302,313 (GRCm39) |
|
probably benign |
Het |
Ulk2 |
G |
A |
11: 61,710,135 (GRCm39) |
H358Y |
probably damaging |
Het |
Utp20 |
A |
T |
10: 88,608,405 (GRCm39) |
I1544N |
possibly damaging |
Het |
Utp20 |
A |
G |
10: 88,608,321 (GRCm39) |
M1572T |
probably benign |
Het |
Zbtb14 |
C |
A |
17: 69,695,497 (GRCm39) |
F398L |
probably damaging |
Het |
|
Other mutations in Lypd10 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00847:Lypd10
|
APN |
7 |
24,413,673 (GRCm39) |
missense |
probably benign |
0.01 |
IGL01353:Lypd10
|
APN |
7 |
24,413,662 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL01603:Lypd10
|
APN |
7 |
24,411,954 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03084:Lypd10
|
APN |
7 |
24,413,605 (GRCm39) |
missense |
possibly damaging |
0.80 |
R0453:Lypd10
|
UTSW |
7 |
24,413,712 (GRCm39) |
missense |
probably benign |
0.18 |
R0657:Lypd10
|
UTSW |
7 |
24,412,872 (GRCm39) |
missense |
probably benign |
0.00 |
R0946:Lypd10
|
UTSW |
7 |
24,413,167 (GRCm39) |
missense |
probably benign |
0.00 |
R1081:Lypd10
|
UTSW |
7 |
24,412,967 (GRCm39) |
splice site |
probably null |
|
R1926:Lypd10
|
UTSW |
7 |
24,413,541 (GRCm39) |
missense |
probably damaging |
1.00 |
R2571:Lypd10
|
UTSW |
7 |
24,412,819 (GRCm39) |
missense |
probably benign |
0.27 |
R3014:Lypd10
|
UTSW |
7 |
24,412,821 (GRCm39) |
missense |
possibly damaging |
0.93 |
R3832:Lypd10
|
UTSW |
7 |
24,413,712 (GRCm39) |
missense |
probably benign |
0.18 |
R4197:Lypd10
|
UTSW |
7 |
24,413,119 (GRCm39) |
missense |
probably benign |
0.01 |
R4705:Lypd10
|
UTSW |
7 |
24,412,934 (GRCm39) |
missense |
probably damaging |
0.99 |
R5609:Lypd10
|
UTSW |
7 |
24,413,711 (GRCm39) |
missense |
possibly damaging |
0.53 |
R6166:Lypd10
|
UTSW |
7 |
24,413,644 (GRCm39) |
missense |
probably benign |
0.00 |
R6385:Lypd10
|
UTSW |
7 |
24,413,535 (GRCm39) |
missense |
probably damaging |
0.97 |
R7477:Lypd10
|
UTSW |
7 |
24,413,673 (GRCm39) |
missense |
probably benign |
0.01 |
R8022:Lypd10
|
UTSW |
7 |
24,413,599 (GRCm39) |
missense |
possibly damaging |
0.92 |
R8169:Lypd10
|
UTSW |
7 |
24,412,000 (GRCm39) |
missense |
probably benign |
0.15 |
R8695:Lypd10
|
UTSW |
7 |
24,413,203 (GRCm39) |
missense |
probably benign |
0.16 |
R9129:Lypd10
|
UTSW |
7 |
24,413,170 (GRCm39) |
missense |
probably benign |
0.00 |
|
Predicted Primers |
PCR Primer
(F):5'- AGCACCAAGGTCCTACTTGACCTC -3'
(R):5'- ACACCCAGGGTTATACTCTCCAGC -3'
Sequencing Primer
(F):5'- AAGCTTTCAGGTATGTGACCC -3'
(R):5'- GGGTTATACTCTCCAGCCACAC -3'
|
Posted On |
2013-11-18 |