Mutagenetix > Incidental Mutation

Incidental Mutation 'R1077:Vmn2r26'

85681

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r26

Ensembl Gene

ENSMUSG00000096630

Gene Name

vomeronasal 2, receptor 26

Synonyms

V2r1b

MMRRC Submission

039163-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.088) question?

Stock #

R1077 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

124024758-124062035 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 124053913 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 536 (V536I)

Ref Sequence

ENSEMBL: ENSMUSP00000032238 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032238]

AlphaFold

Q6TAC4

Predicted Effect

probably benign
Transcript: ENSMUST00000032238
AA Change: V536I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000032238
Gene: ENSMUSG00000096630
AA Change: V536I

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	82	471	1.5e-31	PFAM
Pfam:NCD3G	519	572	4.6e-25	PFAM
Pfam:7tm_3	603	840	1.5e-55	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000158682

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.3%
3x: 98.8%
10x: 97.3%
20x: 94.6%

Validation Efficiency

100% (40/40)

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal vomeronasal sensory neuron physiology and avnosmia. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921528I07Rik	T	C	9: 114,301,702 (GRCm38)		noncoding transcript	Het
Apob	A	G	12: 8,006,017 (GRCm38)	K1500E	probably benign	Het
Atp8b1	A	T	18: 64,573,262 (GRCm38)	Y225*	probably null	Het
Cdc25c	A	T	18: 34,748,973 (GRCm38)		probably benign	Het
Ceacam15	T	C	7: 16,672,075 (GRCm38)	N184D	probably benign	Het
Cntln	T	C	4: 84,996,479 (GRCm38)	S508P	probably damaging	Het
Dhx34	A	G	7: 16,218,368 (GRCm38)	S111P	probably damaging	Het
Dst	A	G	1: 34,164,167 (GRCm38)	E759G	probably damaging	Het
Fis1	G	A	5: 136,965,146 (GRCm38)	A28T	probably damaging	Het
Fsd1	T	C	17: 55,990,542 (GRCm38)		probably null	Het
Gm15293	T	A	8: 21,202,433 (GRCm38)	F90Y	probably benign	Het
Grk6	T	C	13: 55,454,527 (GRCm38)		probably null	Het
Il23r	A	T	6: 67,473,810 (GRCm38)	H228Q	probably benign	Het
Kcnh4	C	T	11: 100,752,338 (GRCm38)	V368I	possibly damaging	Het
Kdr	T	C	5: 75,956,231 (GRCm38)	E728G	probably damaging	Het
Krt33a	T	A	11: 100,015,937 (GRCm38)	M71L	probably benign	Het
Lrrc7	T	G	3: 158,161,143 (GRCm38)	D987A	probably damaging	Het
Naalad2	C	T	9: 18,347,506 (GRCm38)	R491Q	probably damaging	Het
Nedd4l	A	T	18: 65,167,499 (GRCm38)		probably benign	Het
Pramel7	A	G	2: 87,491,190 (GRCm38)	L167S	probably damaging	Het
Prkci	A	G	3: 31,050,192 (GRCm38)	D568G	probably damaging	Het
Psg18	G	A	7: 18,351,075 (GRCm38)	T32I	possibly damaging	Het
Ric8b	T	A	10: 84,970,717 (GRCm38)		probably benign	Het
Rnf213	T	C	11: 119,485,998 (GRCm38)		probably benign	Het
Rttn	T	C	18: 89,064,249 (GRCm38)	V1433A	probably damaging	Het
Sbf2	A	T	7: 110,367,172 (GRCm38)		probably benign	Het
Sdk2	C	T	11: 113,838,646 (GRCm38)		silent	Het
Sfta2	T	C	17: 35,650,127 (GRCm38)		probably benign	Het
Slc17a1	T	A	13: 23,878,450 (GRCm38)		probably benign	Het
Slc6a21	G	A	7: 45,288,202 (GRCm38)	C314Y	probably benign	Het
Smpd4	T	C	16: 17,623,969 (GRCm38)	V35A	probably damaging	Het
Sorl1	T	C	9: 42,014,490 (GRCm38)	D1182G	probably damaging	Het
Syne2	A	G	12: 76,042,035 (GRCm38)	I5056V	possibly damaging	Het
Tex14	T	C	11: 87,519,745 (GRCm38)		probably benign	Het
Tex44	A	G	1: 86,427,055 (GRCm38)	T229A	probably benign	Het
Tfap2b	T	A	1: 19,234,149 (GRCm38)	C394*	probably null	Het
Ttk	T	A	9: 83,844,149 (GRCm38)		probably benign	Het
Wac	A	G	18: 7,921,916 (GRCm38)	T553A	probably damaging	Het
Wdcp	T	A	12: 4,850,685 (GRCm38)	H180Q	probably damaging	Het
Wdr33	A	G	18: 31,835,461 (GRCm38)	H235R	probably benign	Het

Other mutations in Vmn2r26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01070:Vmn2r26	APN	6	124,061,607 (GRCm38)	missense	probably benign	0.00
IGL01370:Vmn2r26	APN	6	124,061,756 (GRCm38)	missense	probably benign	0.08
IGL01603:Vmn2r26	APN	6	124,053,874 (GRCm38)	missense	probably damaging	1.00
IGL01651:Vmn2r26	APN	6	124,050,673 (GRCm38)	missense	probably benign	0.01
IGL02282:Vmn2r26	APN	6	124,061,625 (GRCm38)	missense	probably damaging	1.00
IGL02425:Vmn2r26	APN	6	124,061,818 (GRCm38)	missense	probably damaging	1.00
IGL02551:Vmn2r26	APN	6	124,026,141 (GRCm38)	missense	probably benign	0.11
IGL02690:Vmn2r26	APN	6	124,026,132 (GRCm38)	missense	probably benign	0.14
IGL03002:Vmn2r26	APN	6	124,039,795 (GRCm38)	missense	possibly damaging	0.78
IGL03270:Vmn2r26	APN	6	124,050,819 (GRCm38)	missense	probably benign	0.16
R0032:Vmn2r26	UTSW	6	124,039,899 (GRCm38)	missense	possibly damaging	0.72
R0052:Vmn2r26	UTSW	6	124,062,033 (GRCm38)	makesense	probably null
R0083:Vmn2r26	UTSW	6	124,053,981 (GRCm38)	splice site	probably null
R0682:Vmn2r26	UTSW	6	124,061,170 (GRCm38)	missense	probably damaging	0.97
R1061:Vmn2r26	UTSW	6	124,061,644 (GRCm38)	missense	probably benign	0.12
R1263:Vmn2r26	UTSW	6	124,050,708 (GRCm38)	missense	probably benign
R1579:Vmn2r26	UTSW	6	124,039,747 (GRCm38)	missense	probably benign	0.00
R1741:Vmn2r26	UTSW	6	124,061,472 (GRCm38)	missense	probably damaging	1.00
R1834:Vmn2r26	UTSW	6	124,061,410 (GRCm38)	missense	possibly damaging	0.54
R1838:Vmn2r26	UTSW	6	124,024,771 (GRCm38)	missense	probably benign
R1956:Vmn2r26	UTSW	6	124,053,887 (GRCm38)	missense	probably damaging	1.00
R1996:Vmn2r26	UTSW	6	124,061,185 (GRCm38)	missense	probably damaging	1.00
R2140:Vmn2r26	UTSW	6	124,061,237 (GRCm38)	missense	probably benign	0.01
R2327:Vmn2r26	UTSW	6	124,039,749 (GRCm38)	missense	probably benign	0.07
R2417:Vmn2r26	UTSW	6	124,061,350 (GRCm38)	missense	probably damaging	1.00
R3930:Vmn2r26	UTSW	6	124,025,979 (GRCm38)	missense	probably benign
R4490:Vmn2r26	UTSW	6	124,050,738 (GRCm38)	missense	possibly damaging	0.47
R4629:Vmn2r26	UTSW	6	124,061,191 (GRCm38)	missense	possibly damaging	0.50
R4655:Vmn2r26	UTSW	6	124,061,416 (GRCm38)	missense	probably damaging	1.00
R4709:Vmn2r26	UTSW	6	124,053,965 (GRCm38)	missense	probably damaging	1.00
R4992:Vmn2r26	UTSW	6	124,026,111 (GRCm38)	missense	probably benign	0.00
R5297:Vmn2r26	UTSW	6	124,061,873 (GRCm38)	missense	probably damaging	1.00
R5482:Vmn2r26	UTSW	6	124,061,326 (GRCm38)	missense	possibly damaging	0.88
R5517:Vmn2r26	UTSW	6	124,050,717 (GRCm38)	missense	probably damaging	1.00
R5737:Vmn2r26	UTSW	6	124,039,449 (GRCm38)	missense	probably benign	0.00
R5739:Vmn2r26	UTSW	6	124,025,966 (GRCm38)	missense	probably benign	0.00
R5873:Vmn2r26	UTSW	6	124,061,674 (GRCm38)	missense	probably benign	0.01
R5907:Vmn2r26	UTSW	6	124,039,871 (GRCm38)	missense	probably benign	0.00
R6086:Vmn2r26	UTSW	6	124,039,560 (GRCm38)	missense	possibly damaging	0.48
R6134:Vmn2r26	UTSW	6	124,061,485 (GRCm38)	missense	probably damaging	0.97
R6391:Vmn2r26	UTSW	6	124,061,389 (GRCm38)	missense	probably damaging	1.00
R6428:Vmn2r26	UTSW	6	124,026,080 (GRCm38)	missense	probably benign	0.17
R6637:Vmn2r26	UTSW	6	124,061,691 (GRCm38)	missense	probably damaging	1.00
R6927:Vmn2r26	UTSW	6	124,039,098 (GRCm38)	missense	possibly damaging	0.93
R6953:Vmn2r26	UTSW	6	124,039,782 (GRCm38)	missense	probably benign	0.00
R7173:Vmn2r26	UTSW	6	124,061,296 (GRCm38)	missense	probably benign	0.16
R7206:Vmn2r26	UTSW	6	124,039,768 (GRCm38)	missense	probably benign	0.17
R7208:Vmn2r26	UTSW	6	124,061,989 (GRCm38)	missense	probably damaging	1.00
R7283:Vmn2r26	UTSW	6	124,025,955 (GRCm38)	missense	probably damaging	0.97
R7506:Vmn2r26	UTSW	6	124,039,741 (GRCm38)	missense	probably benign	0.00
R7672:Vmn2r26	UTSW	6	124,039,647 (GRCm38)	missense	probably benign	0.25
R7674:Vmn2r26	UTSW	6	124,039,362 (GRCm38)	missense	probably benign
R7696:Vmn2r26	UTSW	6	124,061,535 (GRCm38)	missense	possibly damaging	0.94
R7716:Vmn2r26	UTSW	6	124,061,745 (GRCm38)	missense	probably damaging	1.00
R7831:Vmn2r26	UTSW	6	124,039,799 (GRCm38)	nonsense	probably null
R8063:Vmn2r26	UTSW	6	124,024,955 (GRCm38)	missense	probably benign	0.00
R8331:Vmn2r26	UTSW	6	124,061,928 (GRCm38)	missense	probably benign	0.22
R8352:Vmn2r26	UTSW	6	124,039,618 (GRCm38)	missense	probably benign	0.09
R8445:Vmn2r26	UTSW	6	124,026,036 (GRCm38)	missense	probably damaging	0.97
R8452:Vmn2r26	UTSW	6	124,039,618 (GRCm38)	missense	probably benign	0.09
R8681:Vmn2r26	UTSW	6	124,024,918 (GRCm38)	missense	probably benign	0.00
R8914:Vmn2r26	UTSW	6	124,062,024 (GRCm38)	missense	probably benign
R9333:Vmn2r26	UTSW	6	124,026,050 (GRCm38)	missense	probably benign	0.13
R9351:Vmn2r26	UTSW	6	124,039,374 (GRCm38)	missense	probably benign
R9436:Vmn2r26	UTSW	6	124,025,867 (GRCm38)	missense	probably damaging	1.00
R9515:Vmn2r26	UTSW	6	124,061,178 (GRCm38)	missense	probably damaging	1.00
RF010:Vmn2r26	UTSW	6	124,039,489 (GRCm38)	missense	possibly damaging	0.90

Predicted Primers

PCR Primer
(F):5'- CTGTTAAAGTACACAGATGCTCTGCTGA -3'
(R):5'- GGTGTTGTGTTACTCACCCCTATCCT -3'

Sequencing Primer
(F):5'- CACAGATGCTCTGCTGAAATTTACC -3'
(R):5'- GTGCATCATTTCCACATTCAGAATC -3'

Posted On

2013-11-18