Incidental Mutation 'R1077:Vmn2r26'
ID 85681
Institutional Source Beutler Lab
Gene Symbol Vmn2r26
Ensembl Gene ENSMUSG00000096630
Gene Name vomeronasal 2, receptor 26
Synonyms V2r1b
MMRRC Submission 039163-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # R1077 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 124024758-124062035 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 124053913 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 536 (V536I)
Ref Sequence ENSEMBL: ENSMUSP00000032238 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032238]
AlphaFold Q6TAC4
Predicted Effect probably benign
Transcript: ENSMUST00000032238
AA Change: V536I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000032238
Gene: ENSMUSG00000096630
AA Change: V536I

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 82 471 1.5e-31 PFAM
Pfam:NCD3G 519 572 4.6e-25 PFAM
Pfam:7tm_3 603 840 1.5e-55 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000158682
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.3%
  • 20x: 94.6%
Validation Efficiency 100% (40/40)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal vomeronasal sensory neuron physiology and avnosmia. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921528I07Rik T C 9: 114,301,702 (GRCm38) noncoding transcript Het
Apob A G 12: 8,006,017 (GRCm38) K1500E probably benign Het
Atp8b1 A T 18: 64,573,262 (GRCm38) Y225* probably null Het
Cdc25c A T 18: 34,748,973 (GRCm38) probably benign Het
Ceacam15 T C 7: 16,672,075 (GRCm38) N184D probably benign Het
Cntln T C 4: 84,996,479 (GRCm38) S508P probably damaging Het
Dhx34 A G 7: 16,218,368 (GRCm38) S111P probably damaging Het
Dst A G 1: 34,164,167 (GRCm38) E759G probably damaging Het
Fis1 G A 5: 136,965,146 (GRCm38) A28T probably damaging Het
Fsd1 T C 17: 55,990,542 (GRCm38) probably null Het
Gm15293 T A 8: 21,202,433 (GRCm38) F90Y probably benign Het
Grk6 T C 13: 55,454,527 (GRCm38) probably null Het
Il23r A T 6: 67,473,810 (GRCm38) H228Q probably benign Het
Kcnh4 C T 11: 100,752,338 (GRCm38) V368I possibly damaging Het
Kdr T C 5: 75,956,231 (GRCm38) E728G probably damaging Het
Krt33a T A 11: 100,015,937 (GRCm38) M71L probably benign Het
Lrrc7 T G 3: 158,161,143 (GRCm38) D987A probably damaging Het
Naalad2 C T 9: 18,347,506 (GRCm38) R491Q probably damaging Het
Nedd4l A T 18: 65,167,499 (GRCm38) probably benign Het
Pramel7 A G 2: 87,491,190 (GRCm38) L167S probably damaging Het
Prkci A G 3: 31,050,192 (GRCm38) D568G probably damaging Het
Psg18 G A 7: 18,351,075 (GRCm38) T32I possibly damaging Het
Ric8b T A 10: 84,970,717 (GRCm38) probably benign Het
Rnf213 T C 11: 119,485,998 (GRCm38) probably benign Het
Rttn T C 18: 89,064,249 (GRCm38) V1433A probably damaging Het
Sbf2 A T 7: 110,367,172 (GRCm38) probably benign Het
Sdk2 C T 11: 113,838,646 (GRCm38) silent Het
Sfta2 T C 17: 35,650,127 (GRCm38) probably benign Het
Slc17a1 T A 13: 23,878,450 (GRCm38) probably benign Het
Slc6a21 G A 7: 45,288,202 (GRCm38) C314Y probably benign Het
Smpd4 T C 16: 17,623,969 (GRCm38) V35A probably damaging Het
Sorl1 T C 9: 42,014,490 (GRCm38) D1182G probably damaging Het
Syne2 A G 12: 76,042,035 (GRCm38) I5056V possibly damaging Het
Tex14 T C 11: 87,519,745 (GRCm38) probably benign Het
Tex44 A G 1: 86,427,055 (GRCm38) T229A probably benign Het
Tfap2b T A 1: 19,234,149 (GRCm38) C394* probably null Het
Ttk T A 9: 83,844,149 (GRCm38) probably benign Het
Wac A G 18: 7,921,916 (GRCm38) T553A probably damaging Het
Wdcp T A 12: 4,850,685 (GRCm38) H180Q probably damaging Het
Wdr33 A G 18: 31,835,461 (GRCm38) H235R probably benign Het
Other mutations in Vmn2r26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01070:Vmn2r26 APN 6 124,061,607 (GRCm38) missense probably benign 0.00
IGL01370:Vmn2r26 APN 6 124,061,756 (GRCm38) missense probably benign 0.08
IGL01603:Vmn2r26 APN 6 124,053,874 (GRCm38) missense probably damaging 1.00
IGL01651:Vmn2r26 APN 6 124,050,673 (GRCm38) missense probably benign 0.01
IGL02282:Vmn2r26 APN 6 124,061,625 (GRCm38) missense probably damaging 1.00
IGL02425:Vmn2r26 APN 6 124,061,818 (GRCm38) missense probably damaging 1.00
IGL02551:Vmn2r26 APN 6 124,026,141 (GRCm38) missense probably benign 0.11
IGL02690:Vmn2r26 APN 6 124,026,132 (GRCm38) missense probably benign 0.14
IGL03002:Vmn2r26 APN 6 124,039,795 (GRCm38) missense possibly damaging 0.78
IGL03270:Vmn2r26 APN 6 124,050,819 (GRCm38) missense probably benign 0.16
R0032:Vmn2r26 UTSW 6 124,039,899 (GRCm38) missense possibly damaging 0.72
R0052:Vmn2r26 UTSW 6 124,062,033 (GRCm38) makesense probably null
R0083:Vmn2r26 UTSW 6 124,053,981 (GRCm38) splice site probably null
R0682:Vmn2r26 UTSW 6 124,061,170 (GRCm38) missense probably damaging 0.97
R1061:Vmn2r26 UTSW 6 124,061,644 (GRCm38) missense probably benign 0.12
R1263:Vmn2r26 UTSW 6 124,050,708 (GRCm38) missense probably benign
R1579:Vmn2r26 UTSW 6 124,039,747 (GRCm38) missense probably benign 0.00
R1741:Vmn2r26 UTSW 6 124,061,472 (GRCm38) missense probably damaging 1.00
R1834:Vmn2r26 UTSW 6 124,061,410 (GRCm38) missense possibly damaging 0.54
R1838:Vmn2r26 UTSW 6 124,024,771 (GRCm38) missense probably benign
R1956:Vmn2r26 UTSW 6 124,053,887 (GRCm38) missense probably damaging 1.00
R1996:Vmn2r26 UTSW 6 124,061,185 (GRCm38) missense probably damaging 1.00
R2140:Vmn2r26 UTSW 6 124,061,237 (GRCm38) missense probably benign 0.01
R2327:Vmn2r26 UTSW 6 124,039,749 (GRCm38) missense probably benign 0.07
R2417:Vmn2r26 UTSW 6 124,061,350 (GRCm38) missense probably damaging 1.00
R3930:Vmn2r26 UTSW 6 124,025,979 (GRCm38) missense probably benign
R4490:Vmn2r26 UTSW 6 124,050,738 (GRCm38) missense possibly damaging 0.47
R4629:Vmn2r26 UTSW 6 124,061,191 (GRCm38) missense possibly damaging 0.50
R4655:Vmn2r26 UTSW 6 124,061,416 (GRCm38) missense probably damaging 1.00
R4709:Vmn2r26 UTSW 6 124,053,965 (GRCm38) missense probably damaging 1.00
R4992:Vmn2r26 UTSW 6 124,026,111 (GRCm38) missense probably benign 0.00
R5297:Vmn2r26 UTSW 6 124,061,873 (GRCm38) missense probably damaging 1.00
R5482:Vmn2r26 UTSW 6 124,061,326 (GRCm38) missense possibly damaging 0.88
R5517:Vmn2r26 UTSW 6 124,050,717 (GRCm38) missense probably damaging 1.00
R5737:Vmn2r26 UTSW 6 124,039,449 (GRCm38) missense probably benign 0.00
R5739:Vmn2r26 UTSW 6 124,025,966 (GRCm38) missense probably benign 0.00
R5873:Vmn2r26 UTSW 6 124,061,674 (GRCm38) missense probably benign 0.01
R5907:Vmn2r26 UTSW 6 124,039,871 (GRCm38) missense probably benign 0.00
R6086:Vmn2r26 UTSW 6 124,039,560 (GRCm38) missense possibly damaging 0.48
R6134:Vmn2r26 UTSW 6 124,061,485 (GRCm38) missense probably damaging 0.97
R6391:Vmn2r26 UTSW 6 124,061,389 (GRCm38) missense probably damaging 1.00
R6428:Vmn2r26 UTSW 6 124,026,080 (GRCm38) missense probably benign 0.17
R6637:Vmn2r26 UTSW 6 124,061,691 (GRCm38) missense probably damaging 1.00
R6927:Vmn2r26 UTSW 6 124,039,098 (GRCm38) missense possibly damaging 0.93
R6953:Vmn2r26 UTSW 6 124,039,782 (GRCm38) missense probably benign 0.00
R7173:Vmn2r26 UTSW 6 124,061,296 (GRCm38) missense probably benign 0.16
R7206:Vmn2r26 UTSW 6 124,039,768 (GRCm38) missense probably benign 0.17
R7208:Vmn2r26 UTSW 6 124,061,989 (GRCm38) missense probably damaging 1.00
R7283:Vmn2r26 UTSW 6 124,025,955 (GRCm38) missense probably damaging 0.97
R7506:Vmn2r26 UTSW 6 124,039,741 (GRCm38) missense probably benign 0.00
R7672:Vmn2r26 UTSW 6 124,039,647 (GRCm38) missense probably benign 0.25
R7674:Vmn2r26 UTSW 6 124,039,362 (GRCm38) missense probably benign
R7696:Vmn2r26 UTSW 6 124,061,535 (GRCm38) missense possibly damaging 0.94
R7716:Vmn2r26 UTSW 6 124,061,745 (GRCm38) missense probably damaging 1.00
R7831:Vmn2r26 UTSW 6 124,039,799 (GRCm38) nonsense probably null
R8063:Vmn2r26 UTSW 6 124,024,955 (GRCm38) missense probably benign 0.00
R8331:Vmn2r26 UTSW 6 124,061,928 (GRCm38) missense probably benign 0.22
R8352:Vmn2r26 UTSW 6 124,039,618 (GRCm38) missense probably benign 0.09
R8445:Vmn2r26 UTSW 6 124,026,036 (GRCm38) missense probably damaging 0.97
R8452:Vmn2r26 UTSW 6 124,039,618 (GRCm38) missense probably benign 0.09
R8681:Vmn2r26 UTSW 6 124,024,918 (GRCm38) missense probably benign 0.00
R8914:Vmn2r26 UTSW 6 124,062,024 (GRCm38) missense probably benign
R9333:Vmn2r26 UTSW 6 124,026,050 (GRCm38) missense probably benign 0.13
R9351:Vmn2r26 UTSW 6 124,039,374 (GRCm38) missense probably benign
R9436:Vmn2r26 UTSW 6 124,025,867 (GRCm38) missense probably damaging 1.00
R9515:Vmn2r26 UTSW 6 124,061,178 (GRCm38) missense probably damaging 1.00
RF010:Vmn2r26 UTSW 6 124,039,489 (GRCm38) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- CTGTTAAAGTACACAGATGCTCTGCTGA -3'
(R):5'- GGTGTTGTGTTACTCACCCCTATCCT -3'

Sequencing Primer
(F):5'- CACAGATGCTCTGCTGAAATTTACC -3'
(R):5'- GTGCATCATTTCCACATTCAGAATC -3'
Posted On 2013-11-18