Mutagenetix > Incidental Mutation

Incidental Mutation 'R1077:Vmn2r26'

85681

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r26

Ensembl Gene

ENSMUSG00000096630

Gene Name

vomeronasal 2, receptor 26

Synonyms

V2r1b

MMRRC Submission

039163-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.094) question?

Stock #

R1077 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

124001717-124038994 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 124030872 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 536 (V536I)

Ref Sequence

ENSEMBL: ENSMUSP00000032238 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032238]

AlphaFold

Q6TAC4

Predicted Effect

probably benign
Transcript: ENSMUST00000032238
AA Change: V536I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000032238
Gene: ENSMUSG00000096630
AA Change: V536I

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	82	471	1.5e-31	PFAM
Pfam:NCD3G	519	572	4.6e-25	PFAM
Pfam:7tm_3	603	840	1.5e-55	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000158682

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.3%
3x: 98.8%
10x: 97.3%
20x: 94.6%

Validation Efficiency

100% (40/40)

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal vomeronasal sensory neuron physiology and avnosmia. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921528I07Rik	T	C	9: 114,130,770 (GRCm39)		noncoding transcript	Het
Apob	A	G	12: 8,056,017 (GRCm39)	K1500E	probably benign	Het
Atp8b1	A	T	18: 64,706,333 (GRCm39)	Y225*	probably null	Het
Cdc25c	A	T	18: 34,882,026 (GRCm39)		probably benign	Het
Ceacam15	T	C	7: 16,406,000 (GRCm39)	N184D	probably benign	Het
Cntln	T	C	4: 84,914,716 (GRCm39)	S508P	probably damaging	Het
Defa41	T	A	8: 21,692,449 (GRCm39)	F90Y	probably benign	Het
Dhx34	A	G	7: 15,952,293 (GRCm39)	S111P	probably damaging	Het
Dst	A	G	1: 34,203,248 (GRCm39)	E759G	probably damaging	Het
Fis1	G	A	5: 136,994,000 (GRCm39)	A28T	probably damaging	Het
Fsd1	T	C	17: 56,297,542 (GRCm39)		probably null	Het
Grk6	T	C	13: 55,602,340 (GRCm39)		probably null	Het
Il23r	A	T	6: 67,450,794 (GRCm39)	H228Q	probably benign	Het
Kcnh4	C	T	11: 100,643,164 (GRCm39)	V368I	possibly damaging	Het
Kdr	T	C	5: 76,116,891 (GRCm39)	E728G	probably damaging	Het
Krt33a	T	A	11: 99,906,763 (GRCm39)	M71L	probably benign	Het
Lrrc7	T	G	3: 157,866,780 (GRCm39)	D987A	probably damaging	Het
Naalad2	C	T	9: 18,258,802 (GRCm39)	R491Q	probably damaging	Het
Nedd4l	A	T	18: 65,300,570 (GRCm39)		probably benign	Het
Pramel7	A	G	2: 87,321,534 (GRCm39)	L167S	probably damaging	Het
Prkci	A	G	3: 31,104,341 (GRCm39)	D568G	probably damaging	Het
Psg18	G	A	7: 18,085,000 (GRCm39)	T32I	possibly damaging	Het
Ric8b	T	A	10: 84,806,581 (GRCm39)		probably benign	Het
Rnf213	T	C	11: 119,376,824 (GRCm39)		probably benign	Het
Rttn	T	C	18: 89,082,373 (GRCm39)	V1433A	probably damaging	Het
Sbf2	A	T	7: 109,966,379 (GRCm39)		probably benign	Het
Sdk2	C	T	11: 113,729,472 (GRCm39)		silent	Het
Sfta2	T	C	17: 35,961,019 (GRCm39)		probably benign	Het
Slc17a1	T	A	13: 24,062,433 (GRCm39)		probably benign	Het
Slc6a21	G	A	7: 44,937,626 (GRCm39)	C314Y	probably benign	Het
Smpd4	T	C	16: 17,441,833 (GRCm39)	V35A	probably damaging	Het
Sorl1	T	C	9: 41,925,786 (GRCm39)	D1182G	probably damaging	Het
Syne2	A	G	12: 76,088,809 (GRCm39)	I5056V	possibly damaging	Het
Tex14	T	C	11: 87,410,571 (GRCm39)		probably benign	Het
Tex44	A	G	1: 86,354,777 (GRCm39)	T229A	probably benign	Het
Tfap2b	T	A	1: 19,304,373 (GRCm39)	C394*	probably null	Het
Ttk	T	A	9: 83,726,202 (GRCm39)		probably benign	Het
Wac	A	G	18: 7,921,916 (GRCm39)	T553A	probably damaging	Het
Wdcp	T	A	12: 4,900,685 (GRCm39)	H180Q	probably damaging	Het
Wdr33	A	G	18: 31,968,514 (GRCm39)	H235R	probably benign	Het

Other mutations in Vmn2r26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01070:Vmn2r26	APN	6	124,038,566 (GRCm39)	missense	probably benign	0.00
IGL01370:Vmn2r26	APN	6	124,038,715 (GRCm39)	missense	probably benign	0.08
IGL01603:Vmn2r26	APN	6	124,030,833 (GRCm39)	missense	probably damaging	1.00
IGL01651:Vmn2r26	APN	6	124,027,632 (GRCm39)	missense	probably benign	0.01
IGL02282:Vmn2r26	APN	6	124,038,584 (GRCm39)	missense	probably damaging	1.00
IGL02425:Vmn2r26	APN	6	124,038,777 (GRCm39)	missense	probably damaging	1.00
IGL02551:Vmn2r26	APN	6	124,003,100 (GRCm39)	missense	probably benign	0.11
IGL02690:Vmn2r26	APN	6	124,003,091 (GRCm39)	missense	probably benign	0.14
IGL03002:Vmn2r26	APN	6	124,016,754 (GRCm39)	missense	possibly damaging	0.78
IGL03270:Vmn2r26	APN	6	124,027,778 (GRCm39)	missense	probably benign	0.16
R0032:Vmn2r26	UTSW	6	124,016,858 (GRCm39)	missense	possibly damaging	0.72
R0052:Vmn2r26	UTSW	6	124,038,992 (GRCm39)	makesense	probably null
R0083:Vmn2r26	UTSW	6	124,030,940 (GRCm39)	splice site	probably null
R0682:Vmn2r26	UTSW	6	124,038,129 (GRCm39)	missense	probably damaging	0.97
R1061:Vmn2r26	UTSW	6	124,038,603 (GRCm39)	missense	probably benign	0.12
R1263:Vmn2r26	UTSW	6	124,027,667 (GRCm39)	missense	probably benign
R1579:Vmn2r26	UTSW	6	124,016,706 (GRCm39)	missense	probably benign	0.00
R1741:Vmn2r26	UTSW	6	124,038,431 (GRCm39)	missense	probably damaging	1.00
R1834:Vmn2r26	UTSW	6	124,038,369 (GRCm39)	missense	possibly damaging	0.54
R1838:Vmn2r26	UTSW	6	124,001,730 (GRCm39)	missense	probably benign
R1956:Vmn2r26	UTSW	6	124,030,846 (GRCm39)	missense	probably damaging	1.00
R1996:Vmn2r26	UTSW	6	124,038,144 (GRCm39)	missense	probably damaging	1.00
R2140:Vmn2r26	UTSW	6	124,038,196 (GRCm39)	missense	probably benign	0.01
R2327:Vmn2r26	UTSW	6	124,016,708 (GRCm39)	missense	probably benign	0.07
R2417:Vmn2r26	UTSW	6	124,038,309 (GRCm39)	missense	probably damaging	1.00
R3930:Vmn2r26	UTSW	6	124,002,938 (GRCm39)	missense	probably benign
R4490:Vmn2r26	UTSW	6	124,027,697 (GRCm39)	missense	possibly damaging	0.47
R4629:Vmn2r26	UTSW	6	124,038,150 (GRCm39)	missense	possibly damaging	0.50
R4655:Vmn2r26	UTSW	6	124,038,375 (GRCm39)	missense	probably damaging	1.00
R4709:Vmn2r26	UTSW	6	124,030,924 (GRCm39)	missense	probably damaging	1.00
R4992:Vmn2r26	UTSW	6	124,003,070 (GRCm39)	missense	probably benign	0.00
R5297:Vmn2r26	UTSW	6	124,038,832 (GRCm39)	missense	probably damaging	1.00
R5482:Vmn2r26	UTSW	6	124,038,285 (GRCm39)	missense	possibly damaging	0.88
R5517:Vmn2r26	UTSW	6	124,027,676 (GRCm39)	missense	probably damaging	1.00
R5737:Vmn2r26	UTSW	6	124,016,408 (GRCm39)	missense	probably benign	0.00
R5739:Vmn2r26	UTSW	6	124,002,925 (GRCm39)	missense	probably benign	0.00
R5873:Vmn2r26	UTSW	6	124,038,633 (GRCm39)	missense	probably benign	0.01
R5907:Vmn2r26	UTSW	6	124,016,830 (GRCm39)	missense	probably benign	0.00
R6086:Vmn2r26	UTSW	6	124,016,519 (GRCm39)	missense	possibly damaging	0.48
R6134:Vmn2r26	UTSW	6	124,038,444 (GRCm39)	missense	probably damaging	0.97
R6391:Vmn2r26	UTSW	6	124,038,348 (GRCm39)	missense	probably damaging	1.00
R6428:Vmn2r26	UTSW	6	124,003,039 (GRCm39)	missense	probably benign	0.17
R6637:Vmn2r26	UTSW	6	124,038,650 (GRCm39)	missense	probably damaging	1.00
R6927:Vmn2r26	UTSW	6	124,016,057 (GRCm39)	missense	possibly damaging	0.93
R6953:Vmn2r26	UTSW	6	124,016,741 (GRCm39)	missense	probably benign	0.00
R7173:Vmn2r26	UTSW	6	124,038,255 (GRCm39)	missense	probably benign	0.16
R7206:Vmn2r26	UTSW	6	124,016,727 (GRCm39)	missense	probably benign	0.17
R7208:Vmn2r26	UTSW	6	124,038,948 (GRCm39)	missense	probably damaging	1.00
R7283:Vmn2r26	UTSW	6	124,002,914 (GRCm39)	missense	probably damaging	0.97
R7506:Vmn2r26	UTSW	6	124,016,700 (GRCm39)	missense	probably benign	0.00
R7672:Vmn2r26	UTSW	6	124,016,606 (GRCm39)	missense	probably benign	0.25
R7674:Vmn2r26	UTSW	6	124,016,321 (GRCm39)	missense	probably benign
R7696:Vmn2r26	UTSW	6	124,038,494 (GRCm39)	missense	possibly damaging	0.94
R7716:Vmn2r26	UTSW	6	124,038,704 (GRCm39)	missense	probably damaging	1.00
R7831:Vmn2r26	UTSW	6	124,016,758 (GRCm39)	nonsense	probably null
R8063:Vmn2r26	UTSW	6	124,001,914 (GRCm39)	missense	probably benign	0.00
R8331:Vmn2r26	UTSW	6	124,038,887 (GRCm39)	missense	probably benign	0.22
R8352:Vmn2r26	UTSW	6	124,016,577 (GRCm39)	missense	probably benign	0.09
R8445:Vmn2r26	UTSW	6	124,002,995 (GRCm39)	missense	probably damaging	0.97
R8452:Vmn2r26	UTSW	6	124,016,577 (GRCm39)	missense	probably benign	0.09
R8681:Vmn2r26	UTSW	6	124,001,877 (GRCm39)	missense	probably benign	0.00
R8914:Vmn2r26	UTSW	6	124,038,983 (GRCm39)	missense	probably benign
R9333:Vmn2r26	UTSW	6	124,003,009 (GRCm39)	missense	probably benign	0.13
R9351:Vmn2r26	UTSW	6	124,016,333 (GRCm39)	missense	probably benign
R9436:Vmn2r26	UTSW	6	124,002,826 (GRCm39)	missense	probably damaging	1.00
R9515:Vmn2r26	UTSW	6	124,038,137 (GRCm39)	missense	probably damaging	1.00
RF010:Vmn2r26	UTSW	6	124,016,448 (GRCm39)	missense	possibly damaging	0.90

Predicted Primers

PCR Primer
(F):5'- CTGTTAAAGTACACAGATGCTCTGCTGA -3'
(R):5'- GGTGTTGTGTTACTCACCCCTATCCT -3'

Sequencing Primer
(F):5'- CACAGATGCTCTGCTGAAATTTACC -3'
(R):5'- GTGCATCATTTCCACATTCAGAATC -3'

Posted On

2013-11-18