Incidental Mutation 'R1078:Olfr1015'
ID85717
Institutional Source Beutler Lab
Gene Symbol Olfr1015
Ensembl Gene ENSMUSG00000033850
Gene Nameolfactory receptor 1015
SynonymsGA_x6K02T2Q125-47264151-47265089, MOR213-3
MMRRC Submission 039164-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.177) question?
Stock #R1078 (G1)
Quality Score225
Status Validated
Chromosome2
Chromosomal Location85782017-85787812 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 85786093 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 194 (V194A)
Ref Sequence ENSEMBL: ENSMUSP00000148957 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047870] [ENSMUST00000215945]
Predicted Effect possibly damaging
Transcript: ENSMUST00000047870
AA Change: V194A

PolyPhen 2 Score 0.527 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000046301
Gene: ENSMUSG00000033850
AA Change: V194A

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.5e-49 PFAM
Pfam:7tm_1 41 290 4.2e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214726
Predicted Effect possibly damaging
Transcript: ENSMUST00000215945
AA Change: V194A

PolyPhen 2 Score 0.527 (Sensitivity: 0.88; Specificity: 0.90)
Meta Mutation Damage Score 0.2694 question?
Coding Region Coverage
  • 1x: 99.7%
  • 3x: 99.1%
  • 10x: 97.4%
  • 20x: 94.4%
Validation Efficiency 96% (53/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610010F05Rik A C 11: 23,611,762 I358S probably benign Het
9130230L23Rik T C 5: 65,988,355 T138A unknown Het
Abi3bp T C 16: 56,654,081 probably null Het
Alpk3 A T 7: 81,078,600 M493L probably benign Het
Bace2 C T 16: 97,356,860 A20V unknown Het
Bms1 T C 6: 118,405,221 D452G probably benign Het
Ccdc187 T C 2: 26,294,377 T3A probably damaging Het
Ctu2 T C 8: 122,481,499 V95A possibly damaging Het
Cyp2a5 A G 7: 26,835,541 K60E probably benign Het
Cyp4f13 T C 17: 32,925,568 H318R probably damaging Het
Dlgap5 G A 14: 47,399,566 T485M probably damaging Het
Dsp C T 13: 38,183,106 probably benign Het
Ell2 T C 13: 75,746,419 probably benign Het
Eml2 A T 7: 19,179,762 Y168F probably benign Het
Ep400 C T 5: 110,735,522 probably benign Het
Ercc4 C A 16: 13,130,197 A336D probably benign Het
Fam189a2 T A 19: 23,973,575 R547S probably benign Het
Fat4 T C 3: 38,983,086 L3629S probably benign Het
Gabbr2 C T 4: 46,664,833 R925H probably damaging Het
Gfi1b A T 2: 28,613,865 W108R probably damaging Het
Gtse1 C T 15: 85,862,307 P108L probably damaging Het
Hfm1 A T 5: 106,878,830 F140I probably damaging Het
Hyal2 T A 9: 107,572,246 H400Q probably benign Het
Igfn1 A G 1: 135,974,847 Y371H probably damaging Het
Iltifb T G 10: 118,290,151 *180C probably null Het
Kdm2b T C 5: 122,961,541 T118A possibly damaging Het
Lama5 A T 2: 180,179,764 probably benign Het
Lgr6 C T 1: 134,994,010 A199T probably damaging Het
Lmo7 C T 14: 101,920,474 probably benign Het
Lrrc37a G T 11: 103,497,631 P2323T unknown Het
Lrrc38 A G 4: 143,350,518 Y117C probably benign Het
Myo1e T C 9: 70,383,999 V1024A probably benign Het
Myrfl T C 10: 116,776,732 N904S possibly damaging Het
Olfr103 T A 17: 37,337,026 I69F probably damaging Het
Olfr1297 T C 2: 111,621,345 H243R probably damaging Het
Pld4 A T 12: 112,763,442 I53F probably benign Het
Plekhg4 T A 8: 105,381,677 C1117* probably null Het
Prss39 G A 1: 34,502,086 E224K probably benign Het
Psme1 G T 14: 55,580,650 G149V probably damaging Het
Soat2 T A 15: 102,153,138 probably null Het
Stab2 C T 10: 86,907,133 probably null Het
Tcf7l2 A G 19: 55,743,195 T127A probably benign Het
Tcp1 T C 17: 12,923,204 probably benign Het
Thbs4 G A 13: 92,762,926 probably benign Het
Tmf1 T C 6: 97,173,300 D482G probably damaging Het
Trim66 G T 7: 109,472,319 P591H probably damaging Het
Umodl1 T C 17: 30,959,373 S108P probably benign Het
Unc79 T G 12: 103,074,853 M715R probably benign Het
Usp34 C A 11: 23,433,175 probably benign Het
Utrn T G 10: 12,455,566 probably null Het
Zfp830 T C 11: 82,765,339 probably null Het
Other mutations in Olfr1015
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00902:Olfr1015 APN 2 85786117 missense probably benign 0.21
IGL01716:Olfr1015 APN 2 85786143 missense probably damaging 0.97
IGL03196:Olfr1015 APN 2 85786021 missense possibly damaging 0.63
IGL03374:Olfr1015 APN 2 85785709 missense probably damaging 1.00
R0329:Olfr1015 UTSW 2 85785803 nonsense probably null
R0330:Olfr1015 UTSW 2 85785803 nonsense probably null
R0714:Olfr1015 UTSW 2 85786399 missense probably damaging 1.00
R0965:Olfr1015 UTSW 2 85786299 missense probably damaging 1.00
R3826:Olfr1015 UTSW 2 85786215 nonsense probably null
R5031:Olfr1015 UTSW 2 85785718 nonsense probably null
R5239:Olfr1015 UTSW 2 85785658 missense probably damaging 1.00
R6120:Olfr1015 UTSW 2 85786341 missense probably damaging 1.00
R6177:Olfr1015 UTSW 2 85785660 missense probably damaging 0.99
R6726:Olfr1015 UTSW 2 85785562 missense possibly damaging 0.51
R6954:Olfr1015 UTSW 2 85786382 nonsense probably null
R7766:Olfr1015 UTSW 2 85785658 missense probably damaging 1.00
Z1176:Olfr1015 UTSW 2 85786120 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTAGCCCATTGCTCTATTCAAGCATC -3'
(R):5'- TGTCTATAAGCGAGTTTTGAACAGCCC -3'

Sequencing Primer
(F):5'- ATTGCTCTATTCAAGCATCATGTC -3'
(R):5'- CTCTCCAGGGAGTAGTTGGAAC -3'
Posted On2013-11-18