Incidental Mutation 'R1078:Tcp1'
ID 85758
Institutional Source Beutler Lab
Gene Symbol Tcp1
Ensembl Gene ENSMUSG00000068039
Gene Name t-complex protein 1
Synonyms c-cpn, TRic, p63, Ccta, Tp63, CCT, Cct1, Tcp-1
MMRRC Submission 039164-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.940) question?
Stock # R1078 (G1)
Quality Score 214
Status Validated
Chromosome 17
Chromosomal Location 13135216-13143954 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to C at 13142091 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000125454 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043923] [ENSMUST00000089024] [ENSMUST00000151287] [ENSMUST00000143961] [ENSMUST00000160378]
AlphaFold P11983
Predicted Effect probably benign
Transcript: ENSMUST00000043923
SMART Domains Protein: ENSMUSP00000045912
Gene: ENSMUSG00000062480

DomainStartEndE-ValueType
Pfam:Thiolase_N 8 267 2.9e-97 PFAM
Pfam:Thiolase_C 274 396 1.3e-52 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000082703
Predicted Effect noncoding transcript
Transcript: ENSMUST00000083171
Predicted Effect probably benign
Transcript: ENSMUST00000089024
SMART Domains Protein: ENSMUSP00000086418
Gene: ENSMUSG00000068039

DomainStartEndE-ValueType
Pfam:Cpn60_TCP1 1 486 1.9e-132 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129632
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133003
Predicted Effect probably benign
Transcript: ENSMUST00000151287
SMART Domains Protein: ENSMUSP00000116108
Gene: ENSMUSG00000068039

DomainStartEndE-ValueType
Pfam:Cpn60_TCP1 28 535 6.3e-156 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138709
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137289
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151715
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160921
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134665
Predicted Effect probably benign
Transcript: ENSMUST00000143961
SMART Domains Protein: ENSMUSP00000116511
Gene: ENSMUSG00000068039

DomainStartEndE-ValueType
Pfam:Cpn60_TCP1 28 103 1.2e-29 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000160378
SMART Domains Protein: ENSMUSP00000125454
Gene: ENSMUSG00000062480

DomainStartEndE-ValueType
Pfam:Thiolase_N 5 248 5.6e-91 PFAM
Coding Region Coverage
  • 1x: 99.7%
  • 3x: 99.1%
  • 10x: 97.4%
  • 20x: 94.4%
Validation Efficiency 96% (53/55)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010]
PHENOTYPE: There are two electrophoretic alleles known; allele a occurs in all complete t haplotype chromosomes and allele b in wild-type strains. There are multiple changes between the amino acid sequences of the TCP1A and TCP1B proteins encoded by the two alleles. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130230L23Rik T C 5: 66,145,698 (GRCm39) T138A unknown Het
Abi3bp T C 16: 56,474,444 (GRCm39) probably null Het
Alpk3 A T 7: 80,728,348 (GRCm39) M493L probably benign Het
Bace2 C T 16: 97,158,060 (GRCm39) A20V unknown Het
Bms1 T C 6: 118,382,182 (GRCm39) D452G probably benign Het
Ccdc187 T C 2: 26,184,389 (GRCm39) T3A probably damaging Het
Ctu2 T C 8: 123,208,238 (GRCm39) V95A possibly damaging Het
Cyp2a5 A G 7: 26,534,966 (GRCm39) K60E probably benign Het
Cyp4f13 T C 17: 33,144,542 (GRCm39) H318R probably damaging Het
Dlgap5 G A 14: 47,637,023 (GRCm39) T485M probably damaging Het
Dsp C T 13: 38,367,082 (GRCm39) probably benign Het
Ell2 T C 13: 75,894,538 (GRCm39) probably benign Het
Eml2 A T 7: 18,913,687 (GRCm39) Y168F probably benign Het
Entrep1 T A 19: 23,950,939 (GRCm39) R547S probably benign Het
Ep400 C T 5: 110,883,388 (GRCm39) probably benign Het
Ercc4 C A 16: 12,948,061 (GRCm39) A336D probably benign Het
Fat4 T C 3: 39,037,235 (GRCm39) L3629S probably benign Het
Gabbr2 C T 4: 46,664,833 (GRCm39) R925H probably damaging Het
Gfi1b A T 2: 28,503,877 (GRCm39) W108R probably damaging Het
Gtse1 C T 15: 85,746,508 (GRCm39) P108L probably damaging Het
Hfm1 A T 5: 107,026,696 (GRCm39) F140I probably damaging Het
Hyal2 T A 9: 107,449,445 (GRCm39) H400Q probably benign Het
Igfn1 A G 1: 135,902,585 (GRCm39) Y371H probably damaging Het
Il22b T G 10: 118,126,056 (GRCm39) *180C probably null Het
Kdm2b T C 5: 123,099,604 (GRCm39) T118A possibly damaging Het
Lama5 A T 2: 179,821,557 (GRCm39) probably benign Het
Lgr6 C T 1: 134,921,748 (GRCm39) A199T probably damaging Het
Lmo7 C T 14: 102,157,910 (GRCm39) probably benign Het
Lrrc37a G T 11: 103,388,457 (GRCm39) P2323T unknown Het
Lrrc38 A G 4: 143,077,088 (GRCm39) Y117C probably benign Het
Myo1e T C 9: 70,291,281 (GRCm39) V1024A probably benign Het
Myrfl T C 10: 116,612,637 (GRCm39) N904S possibly damaging Het
Or12d13 T A 17: 37,647,917 (GRCm39) I69F probably damaging Het
Or4k47 T C 2: 111,451,690 (GRCm39) H243R probably damaging Het
Or9g4b T C 2: 85,616,437 (GRCm39) V194A possibly damaging Het
Pld4 A T 12: 112,729,876 (GRCm39) I53F probably benign Het
Plekhg4 T A 8: 106,108,309 (GRCm39) C1117* probably null Het
Prss39 G A 1: 34,541,167 (GRCm39) E224K probably benign Het
Psme1 G T 14: 55,818,107 (GRCm39) G149V probably damaging Het
Sanbr A C 11: 23,561,762 (GRCm39) I358S probably benign Het
Soat2 T A 15: 102,061,573 (GRCm39) probably null Het
Stab2 C T 10: 86,742,997 (GRCm39) probably null Het
Tcf7l2 A G 19: 55,731,627 (GRCm39) T127A probably benign Het
Thbs4 G A 13: 92,899,434 (GRCm39) probably benign Het
Tmf1 T C 6: 97,150,261 (GRCm39) D482G probably damaging Het
Trim66 G T 7: 109,071,526 (GRCm39) P591H probably damaging Het
Umodl1 T C 17: 31,178,347 (GRCm39) S108P probably benign Het
Unc79 T G 12: 103,041,112 (GRCm39) M715R probably benign Het
Usp34 C A 11: 23,383,175 (GRCm39) probably benign Het
Utrn T G 10: 12,331,310 (GRCm39) probably null Het
Zfp830 T C 11: 82,656,165 (GRCm39) probably null Het
Other mutations in Tcp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01624:Tcp1 APN 17 13,138,812 (GRCm39) missense probably benign 0.00
IGL01859:Tcp1 APN 17 13,141,571 (GRCm39) missense possibly damaging 0.95
IGL02635:Tcp1 APN 17 13,142,296 (GRCm39) missense probably benign 0.35
R0164:Tcp1 UTSW 17 13,141,634 (GRCm39) unclassified probably benign
R0308:Tcp1 UTSW 17 13,139,306 (GRCm39) missense probably benign 0.14
R0452:Tcp1 UTSW 17 13,143,239 (GRCm39) missense probably benign 0.14
R0661:Tcp1 UTSW 17 13,142,200 (GRCm39) missense probably benign 0.02
R0674:Tcp1 UTSW 17 13,142,131 (GRCm39) missense probably damaging 1.00
R1434:Tcp1 UTSW 17 13,141,493 (GRCm39) splice site probably null
R1678:Tcp1 UTSW 17 13,139,310 (GRCm39) missense probably benign
R1801:Tcp1 UTSW 17 13,141,089 (GRCm39) nonsense probably null
R2063:Tcp1 UTSW 17 13,139,699 (GRCm39) missense probably damaging 0.99
R4061:Tcp1 UTSW 17 13,139,750 (GRCm39) missense probably benign
R4078:Tcp1 UTSW 17 13,136,970 (GRCm39) missense probably benign 0.05
R5516:Tcp1 UTSW 17 13,143,221 (GRCm39) missense probably damaging 0.98
R5620:Tcp1 UTSW 17 13,138,224 (GRCm39) splice site probably null
R5764:Tcp1 UTSW 17 13,135,489 (GRCm39) missense probably benign 0.10
R6729:Tcp1 UTSW 17 13,142,140 (GRCm39) missense probably damaging 1.00
R7112:Tcp1 UTSW 17 13,136,760 (GRCm39) missense probably damaging 0.99
R7614:Tcp1 UTSW 17 13,141,540 (GRCm39) missense possibly damaging 0.83
R7718:Tcp1 UTSW 17 13,141,049 (GRCm39) missense probably damaging 1.00
R8194:Tcp1 UTSW 17 13,141,621 (GRCm39) critical splice donor site probably null
R8239:Tcp1 UTSW 17 13,139,738 (GRCm39) missense probably benign 0.00
R8781:Tcp1 UTSW 17 13,143,263 (GRCm39) missense probably damaging 1.00
R9065:Tcp1 UTSW 17 13,139,210 (GRCm39) missense probably damaging 0.99
R9231:Tcp1 UTSW 17 13,136,761 (GRCm39) missense probably damaging 1.00
R9347:Tcp1 UTSW 17 13,136,687 (GRCm39) missense probably benign 0.00
R9402:Tcp1 UTSW 17 13,141,505 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- AGACATTGTTCCTGGTGCCTTATGC -3'
(R):5'- ACCCTATGCCTTTGAAAGCAGCC -3'

Sequencing Primer
(F):5'- cgtgtagccctgactgtcc -3'
(R):5'- TATATGGACAGGGCAGCTTCTAC -3'
Posted On 2013-11-18