Incidental Mutation 'R1079:Olfr287'
Institutional Source Beutler Lab
Gene Symbol Olfr287
Ensembl Gene ENSMUSG00000090129
Gene Nameolfactory receptor 287
SynonymsMOR286-1, GA_x6K02T2NBG7-5548201-5549154
MMRRC Submission 039165-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.079) question?
Stock #R1079 (G1)
Quality Score225
Status Validated
Chromosomal Location98206971-98221056 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 98208342 bp
Amino Acid Change Valine to Glycine at position 14 (V14G)
Ref Sequence ENSEMBL: ENSMUSP00000129271 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000142443] [ENSMUST00000170618]
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132068
Predicted Effect probably benign
Transcript: ENSMUST00000142443
SMART Domains Protein: ENSMUSP00000119026
Gene: ENSMUSG00000075427

low complexity region 19 34 N/A INTRINSIC
Pfam:7tm_1 38 287 1.2e-32 PFAM
Pfam:7tm_4 136 280 3.9e-34 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000142443
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145768
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155603
SMART Domains Protein: ENSMUSP00000118682
Gene: ENSMUSG00000090129

Pfam:7tm_1 7 205 2.5e-30 PFAM
Pfam:7tm_4 105 209 4.5e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000170618
AA Change: V14G

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000129271
Gene: ENSMUSG00000090129
AA Change: V14G

Pfam:7tm_4 37 313 1e-50 PFAM
Pfam:7tm_1 47 296 6e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205339
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206224
Meta Mutation Damage Score 0.7456 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.6%
  • 20x: 95.6%
Validation Efficiency 98% (46/47)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2200002J24Rik T C 7: 30,699,784 M1T probably null Het
Adam25 T C 8: 40,755,476 V593A possibly damaging Het
Agrn C T 4: 156,177,225 C536Y probably damaging Het
Amigo3 T C 9: 108,053,852 M158T probably benign Het
Arsa G A 15: 89,474,225 probably benign Het
Baz1a T A 12: 54,895,000 I1474L possibly damaging Het
Cfap65 G A 1: 74,902,447 A1776V probably damaging Het
Cfap65 A G 1: 74,905,713 V1455A probably damaging Het
Cnot6 G T 11: 49,685,103 D176E probably benign Het
Crot A T 5: 8,993,504 probably null Het
Cryba2 A T 1: 74,890,558 V140E probably damaging Het
Dennd4b G A 3: 90,271,178 R516K probably benign Het
Dst C A 1: 34,186,863 T1697N possibly damaging Het
Eftud2 G T 11: 102,840,044 Y837* probably null Het
Evpl G T 11: 116,230,068 T447K possibly damaging Het
Fam183b A G 11: 58,801,794 Y36H probably benign Het
Fndc3a A T 14: 72,589,807 M146K possibly damaging Het
Folh1 G T 7: 86,771,881 T80K probably damaging Het
Gm4922 T A 10: 18,784,338 Y212F probably damaging Het
Gtf2i T G 5: 134,242,894 probably benign Het
Hipk3 A G 2: 104,471,698 F50L probably benign Het
Ifit1bl2 T A 19: 34,619,485 T244S probably benign Het
Ikzf2 T C 1: 69,539,105 D341G possibly damaging Het
Kif3a G C 11: 53,570,581 V17L possibly damaging Het
Lgr6 C T 1: 134,994,010 A199T probably damaging Het
Lzts2 T A 19: 45,023,544 N137K probably damaging Het
Mphosph8 T A 14: 56,674,259 D246E probably damaging Het
Myh14 T C 7: 44,630,002 E918G probably damaging Het
N6amt1 T C 16: 87,356,198 V52A probably damaging Het
Npr2 A C 4: 43,643,654 T561P probably damaging Het
Nudt12 G A 17: 59,011,037 probably benign Het
Olfr1054 T A 2: 86,332,841 R172W probably damaging Het
Olfr1151 A G 2: 87,857,355 Y60C probably damaging Het
Olfr430 A T 1: 174,069,466 H56L possibly damaging Het
Pan2 A G 10: 128,318,238 T1050A probably damaging Het
Rad17 G T 13: 100,633,899 D213E probably benign Het
Sall2 T A 14: 52,313,203 H843L probably benign Het
Sdk2 C T 11: 113,838,646 silent Het
Sema3e A T 5: 14,225,655 N258I probably benign Het
Siglec1 G A 2: 131,079,377 R625* probably null Het
Slc15a3 T C 19: 10,855,980 S454P probably benign Het
Sp110 G A 1: 85,589,104 probably benign Het
Spatc1l T C 10: 76,563,907 S88P probably damaging Het
Ssh3 A C 19: 4,266,549 L143R probably damaging Het
Ttn C T 2: 76,756,996 probably benign Het
Vps35 A G 8: 85,279,054 L306S probably damaging Het
Zfp729a T C 13: 67,619,675 I812V possibly damaging Het
Other mutations in Olfr287
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01368:Olfr287 APN 15 98207500 missense probably damaging 0.99
IGL02952:Olfr287 APN 15 98207589 missense probably damaging 1.00
PIT4378001:Olfr287 UTSW 15 98207571 missense probably damaging 1.00
R5932:Olfr287 UTSW 15 98207415 makesense probably null
Predicted Primers PCR Primer

Sequencing Primer
Posted On2013-11-18