Incidental Mutation 'R1065:Ppp1r3g'
ID 85975
Institutional Source Beutler Lab
Gene Symbol Ppp1r3g
Ensembl Gene ENSMUSG00000050423
Gene Name protein phosphatase 1, regulatory subunit 3G
Synonyms 1600032L17Rik
MMRRC Submission 039151-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R1065 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 36142822-36154371 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 36153418 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 279 (D279E)
Ref Sequence ENSEMBL: ENSMUSP00000153702 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000132661] [ENSMUST00000225537]
AlphaFold Q9CW07
Predicted Effect probably benign
Transcript: ENSMUST00000132661
AA Change: D279E

PolyPhen 2 Score 0.074 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000122712
Gene: ENSMUSG00000050423
AA Change: D279E

DomainStartEndE-ValueType
low complexity region 88 102 N/A INTRINSIC
Pfam:CBM_21 202 339 9.2e-29 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000172766
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223592
Predicted Effect probably benign
Transcript: ENSMUST00000225537
AA Change: D279E

PolyPhen 2 Score 0.074 (Sensitivity: 0.93; Specificity: 0.85)
Meta Mutation Damage Score 0.1085 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.6%
  • 20x: 95.5%
Validation Efficiency 97% (36/37)
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cd300ld2 T C 11: 114,904,586 (GRCm39) T94A probably damaging Het
Cdc42bpg G A 19: 6,372,856 (GRCm39) S1515N probably damaging Het
Ckb T C 12: 111,637,681 (GRCm39) E150G probably benign Het
Clec2m A G 6: 129,300,013 (GRCm39) I155T possibly damaging Het
Cobl T A 11: 12,204,327 (GRCm39) M785L possibly damaging Het
Col6a5 T C 9: 105,758,982 (GRCm39) N2075D probably damaging Het
Commd7 G C 2: 153,461,447 (GRCm39) probably benign Het
Corin G A 5: 72,458,993 (GRCm39) R927* probably null Het
Dync2i1 C T 12: 116,219,696 (GRCm39) R82H probably damaging Het
Ift122 A T 6: 115,852,286 (GRCm39) probably null Het
Il1b G A 2: 129,209,927 (GRCm39) T83I probably benign Het
Ints4 T C 7: 97,157,099 (GRCm39) probably null Het
Msh6 T G 17: 88,295,891 (GRCm39) probably benign Het
Mtmr3 T C 11: 4,442,859 (GRCm39) K392E probably damaging Het
Or5t9 A G 2: 86,659,888 (GRCm39) H264R probably damaging Het
Pde3a T C 6: 141,422,458 (GRCm39) probably benign Het
Pde6h A C 6: 136,936,368 (GRCm39) K37T probably damaging Het
Plat C A 8: 23,266,879 (GRCm39) D290E probably damaging Het
Polk A C 13: 96,644,760 (GRCm39) L122R probably damaging Het
Ptpru T C 4: 131,535,651 (GRCm39) E370G possibly damaging Het
Ralgapa2 T C 2: 146,292,478 (GRCm39) Y187C probably benign Het
Rps6ka2 C T 17: 7,549,157 (GRCm39) probably benign Het
Slit3 T C 11: 35,012,462 (GRCm39) S41P possibly damaging Het
Smarca5 A T 8: 81,431,343 (GRCm39) L958Q probably damaging Het
Snx9 T C 17: 5,952,636 (GRCm39) probably benign Het
Stkld1 A T 2: 26,830,050 (GRCm39) N72I probably damaging Het
Strc C A 2: 121,197,132 (GRCm39) D1532Y probably damaging Het
Sucla2 C T 14: 73,798,074 (GRCm39) probably benign Het
Svil T G 18: 5,063,777 (GRCm39) probably benign Het
Traf3ip1 T A 1: 91,428,506 (GRCm39) D122E unknown Het
Vmn2r7 A T 3: 64,614,559 (GRCm39) D509E possibly damaging Het
Vps52 C A 17: 34,180,213 (GRCm39) Q306K probably benign Het
Zfp407 C T 18: 84,577,898 (GRCm39) A1072T probably benign Het
Zfp418 C A 7: 7,184,561 (GRCm39) Q175K probably benign Het
Zxdc T C 6: 90,355,885 (GRCm39) S465P probably damaging Het
Other mutations in Ppp1r3g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01946:Ppp1r3g APN 13 36,152,978 (GRCm39) missense possibly damaging 0.90
IGL02890:Ppp1r3g APN 13 36,153,314 (GRCm39) missense probably damaging 0.98
R0413:Ppp1r3g UTSW 13 36,153,331 (GRCm39) missense probably damaging 1.00
R4497:Ppp1r3g UTSW 13 36,153,603 (GRCm39) missense probably benign 0.15
R5677:Ppp1r3g UTSW 13 36,153,245 (GRCm39) missense probably damaging 1.00
R6705:Ppp1r3g UTSW 13 36,152,880 (GRCm39) missense probably benign 0.08
R8832:Ppp1r3g UTSW 13 36,153,143 (GRCm39) nonsense probably null
R9127:Ppp1r3g UTSW 13 36,152,621 (GRCm39) missense probably benign
R9287:Ppp1r3g UTSW 13 36,152,834 (GRCm39) missense possibly damaging 0.92
R9626:Ppp1r3g UTSW 13 36,153,612 (GRCm39) missense probably benign 0.08
X0027:Ppp1r3g UTSW 13 36,153,206 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCAACGATGCCTGATCCTCTCTTG -3'
(R):5'- ATCGCTCCACGCTCTGTCAATG -3'

Sequencing Primer
(F):5'- GACAGCGAGTGTGCCTG -3'
(R):5'- TCTGTGGAGCACACATAGC -3'
Posted On 2013-11-18