Mutagenetix > Incidental Mutation

Incidental Mutation 'R1069:Tas2r131'

86126

Institutional Source

Beutler Lab

Gene Symbol

Tas2r131

Ensembl Gene

ENSMUSG00000057699

Gene Name

taste receptor, type 2, member 131

Synonyms

mGR31, Tas2r31, mt2r61, T2R31

MMRRC Submission

039155-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1069 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

132956884-132957919 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 132957825 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Lysine at position 7 (R7K)

Ref Sequence

ENSEMBL: ENSMUSP00000080736 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000082085]

AlphaFold

Q7M708

Predicted Effect

probably benign
Transcript: ENSMUST00000082085
AA Change: R7K

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)

SMART Domains

Protein: ENSMUSP00000080736
Gene: ENSMUSG00000057699
AA Change: R7K

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	293	1.2e-66	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.4%
3x: 98.8%
10x: 97.5%
20x: 95.4%

Validation Efficiency

100% (33/33)

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610203C20Rik	G	A	9: 41,590,298	R151H	possibly damaging	Het
4921524L21Rik	A	G	18: 6,624,037	N106S	probably benign	Het
Akr1c21	C	A	13: 4,575,334		probably benign	Het
Alpk2	G	A	18: 65,305,014	R1570C	probably benign	Het
Atp8b3	G	A	10: 80,531,018	R249C	probably damaging	Het
Cacnb4	C	A	2: 52,455,611	R252I	probably damaging	Het
Cars	T	C	7: 143,570,107	T480A	probably benign	Het
Ccnf	A	T	17: 24,223,997	C745*	probably null	Het
Ccr8	A	G	9: 120,094,217	I133V	probably benign	Het
Cndp1	G	A	18: 84,634,652		probably benign	Het
Dgkq	T	C	5: 108,656,037		probably benign	Het
Ecd	A	G	14: 20,333,436	C312R	probably damaging	Het
Epp13	A	T	7: 6,255,922		probably null	Het
Gstm1	T	C	3: 108,012,748	S226G	probably damaging	Het
Gtf3c3	C	T	1: 54,417,778	A488T	probably damaging	Het
Hacd4	T	A	4: 88,437,502	I49L	probably damaging	Het
Hid1	T	C	11: 115,356,765	N269S	probably damaging	Het
Ifitm3	A	T	7: 141,009,900		probably benign	Het
Kctd9	C	T	14: 67,729,420		probably benign	Het
Kif20b	T	C	19: 34,950,851	L1131P	probably damaging	Het
Kif2c	T	C	4: 117,178,153	T33A	probably damaging	Het
Lipc	T	C	9: 70,823,537	T38A	probably benign	Het
Lrguk	A	C	6: 34,048,883	I205L	possibly damaging	Het
Ncapg	T	A	5: 45,675,930		probably benign	Het
Ptprd	A	G	4: 75,998,487		probably benign	Het
Ptprd	T	A	4: 76,100,633	K635*	probably null	Het
Sap130	G	A	18: 31,711,629	V898I	probably damaging	Het
Sned1	G	A	1: 93,281,654	V830M	possibly damaging	Het
Svep1	C	T	4: 58,070,239	G2516R	probably damaging	Het
Tfpi	A	G	2: 84,453,792		probably benign	Het
Trim80	T	C	11: 115,448,083	C580R	probably damaging	Het
Ttn	T	A	2: 76,969,929	I312F	unknown	Het

Other mutations in Tas2r131

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00592:Tas2r131	APN	6	132957196	missense	probably damaging	1.00
IGL00795:Tas2r131	APN	6	132957591	missense	possibly damaging	0.94
IGL01023:Tas2r131	APN	6	132957801	missense	probably damaging	1.00
IGL02439:Tas2r131	APN	6	132957769	missense	probably damaging	1.00
R0335:Tas2r131	UTSW	6	132957829	missense	probably benign
R0523:Tas2r131	UTSW	6	132957451	missense	possibly damaging	0.71
R1056:Tas2r131	UTSW	6	132957067	missense	possibly damaging	0.68
R4073:Tas2r131	UTSW	6	132957839	nonsense	probably null
R4719:Tas2r131	UTSW	6	132956973	missense	probably damaging	1.00
R5002:Tas2r131	UTSW	6	132957151	missense	probably benign	0.00
R5049:Tas2r131	UTSW	6	132957577	missense	probably damaging	1.00
R5635:Tas2r131	UTSW	6	132957608	missense	probably benign	0.27
R5905:Tas2r131	UTSW	6	132957676	missense	probably benign	0.02
R6028:Tas2r131	UTSW	6	132957676	missense	probably benign	0.02
R6229:Tas2r131	UTSW	6	132957022	missense	probably damaging	1.00
R7115:Tas2r131	UTSW	6	132957604	missense	probably benign	0.07
R7561:Tas2r131	UTSW	6	132956958	missense	probably benign	0.26
R7741:Tas2r131	UTSW	6	132957475	missense	possibly damaging	0.60
R7810:Tas2r131	UTSW	6	132957742	missense	probably benign	0.11
R8878:Tas2r131	UTSW	6	132957504	missense	probably damaging	1.00
R9506:Tas2r131	UTSW	6	132957061	missense	possibly damaging	0.94
X0025:Tas2r131	UTSW	6	132957538	missense	probably damaging	1.00
Z1177:Tas2r131	UTSW	6	132956997	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GCAGGTGGCAAGCCATGTTGATAG -3'
(R):5'- ACAGAGTGCAGTGTTTCAGGTGAG -3'

Sequencing Primer
(F):5'- ATAGAAATGAGGCGCTAGTTCTTG -3'
(R):5'- CATCAATGGGAATTTTGAAGGCAC -3'

Posted On

2013-11-18