Incidental Mutation 'R1069:Ifitm3'
ID 86128
Institutional Source Beutler Lab
Gene Symbol Ifitm3
Ensembl Gene ENSMUSG00000025492
Gene Name interferon induced transmembrane protein 3
Synonyms mil-1, Fgls, 1110004C05Rik, fragilis, IP15
MMRRC Submission 039155-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1069 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 141009586-141010770 bp(-) (GRCm38)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 141009900 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000026565 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026565]
AlphaFold Q9CQW9
Predicted Effect probably benign
Transcript: ENSMUST00000026565
SMART Domains Protein: ENSMUSP00000026565
Gene: ENSMUSG00000025492

Pfam:CD225 47 130 7.6e-33 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.4%
Validation Efficiency 100% (33/33)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined. [provided by RefSeq, May 2012]
PHENOTYPE: Mice homozygous for a reporter allele are viable and fertile with no detectable defects in embryogenesis or germ cell development but show increased susceptibility to respiratory syncytial virus and influenza A virus infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610203C20Rik G A 9: 41,590,298 R151H possibly damaging Het
4921524L21Rik A G 18: 6,624,037 N106S probably benign Het
Akr1c21 C A 13: 4,575,334 probably benign Het
Alpk2 G A 18: 65,305,014 R1570C probably benign Het
Atp8b3 G A 10: 80,531,018 R249C probably damaging Het
Cacnb4 C A 2: 52,455,611 R252I probably damaging Het
Cars T C 7: 143,570,107 T480A probably benign Het
Ccnf A T 17: 24,223,997 C745* probably null Het
Ccr8 A G 9: 120,094,217 I133V probably benign Het
Cndp1 G A 18: 84,634,652 probably benign Het
Dgkq T C 5: 108,656,037 probably benign Het
Ecd A G 14: 20,333,436 C312R probably damaging Het
Epp13 A T 7: 6,255,922 probably null Het
Gstm1 T C 3: 108,012,748 S226G probably damaging Het
Gtf3c3 C T 1: 54,417,778 A488T probably damaging Het
Hacd4 T A 4: 88,437,502 I49L probably damaging Het
Hid1 T C 11: 115,356,765 N269S probably damaging Het
Kctd9 C T 14: 67,729,420 probably benign Het
Kif20b T C 19: 34,950,851 L1131P probably damaging Het
Kif2c T C 4: 117,178,153 T33A probably damaging Het
Lipc T C 9: 70,823,537 T38A probably benign Het
Lrguk A C 6: 34,048,883 I205L possibly damaging Het
Ncapg T A 5: 45,675,930 probably benign Het
Ptprd A G 4: 75,998,487 probably benign Het
Ptprd T A 4: 76,100,633 K635* probably null Het
Sap130 G A 18: 31,711,629 V898I probably damaging Het
Sned1 G A 1: 93,281,654 V830M possibly damaging Het
Svep1 C T 4: 58,070,239 G2516R probably damaging Het
Tas2r131 C T 6: 132,957,825 R7K probably benign Het
Tfpi A G 2: 84,453,792 probably benign Het
Trim80 T C 11: 115,448,083 C580R probably damaging Het
Ttn T A 2: 76,969,929 I312F unknown Het
Other mutations in Ifitm3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02039:Ifitm3 APN 7 141010650 utr 5 prime probably benign
IGL02478:Ifitm3 APN 7 141009874 missense possibly damaging 0.68
IGL02889:Ifitm3 APN 7 141009879 missense probably damaging 1.00
I0000:Ifitm3 UTSW 7 141010528 missense possibly damaging 0.85
R4019:Ifitm3 UTSW 7 141009859 missense possibly damaging 0.71
R4991:Ifitm3 UTSW 7 141010459 missense probably damaging 1.00
R5288:Ifitm3 UTSW 7 141010641 missense probably benign 0.00
R5385:Ifitm3 UTSW 7 141010641 missense probably benign 0.00
R5386:Ifitm3 UTSW 7 141010641 missense probably benign 0.00
R5543:Ifitm3 UTSW 7 141009817 missense unknown
R7071:Ifitm3 UTSW 7 141010524 missense probably benign 0.03
R7602:Ifitm3 UTSW 7 141010459 missense probably damaging 1.00
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2013-11-18