Incidental Mutation 'IGL01459:Olfr792'
ID87932
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr792
Ensembl Gene ENSMUSG00000094496
Gene Nameolfactory receptor 792
SynonymsGA_x6K02T2PULF-11219415-11220350, MOR108-2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.109) question?
Stock #IGL01459
Quality Score
Status
Chromosome10
Chromosomal Location129539162-129542534 bp(+) (GRCm38)
Type of Mutationstart codon destroyed
DNA Base Change (assembly) G to A at 129540541 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Isoleucine at position 1 (M1I)
Ref Sequence ENSEMBL: ENSMUSP00000149872 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076575] [ENSMUST00000215436]
Predicted Effect probably null
Transcript: ENSMUST00000076575
AA Change: M1I

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000096707
Gene: ENSMUSG00000094496
AA Change: M1I

DomainStartEndE-ValueType
Pfam:7tm_4 28 306 1.9e-53 PFAM
Pfam:7tm_1 39 288 4.7e-25 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000215436
AA Change: M1I

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp2a2 A G 5: 122,469,652 S265P probably benign Het
Brwd1 A G 16: 96,047,420 F520L probably damaging Het
Cdh5 A T 8: 104,137,817 D470V probably damaging Het
Cdr2l A G 11: 115,390,552 R41G probably damaging Het
Csrnp1 C T 9: 119,972,958 C345Y probably damaging Het
Dscaml1 T A 9: 45,742,683 Y1419* probably null Het
Entpd3 T C 9: 120,561,941 S420P probably damaging Het
Epb41 A G 4: 131,964,128 probably benign Het
Erg A G 16: 95,361,282 S322P probably damaging Het
Fndc3b T A 3: 27,461,740 H639L probably benign Het
Grwd1 C T 7: 45,830,410 probably null Het
Kbtbd8 A G 6: 95,122,808 N356D probably benign Het
Kif15 A G 9: 122,975,755 E189G probably damaging Het
Kif2b T C 11: 91,577,023 K145E possibly damaging Het
Kif5c A G 2: 49,735,557 D613G probably benign Het
Lipe T G 7: 25,383,542 Q457P probably damaging Het
Lrp1b A T 2: 40,860,714 I2946N probably damaging Het
Mtf2 C T 5: 108,080,943 P42S probably damaging Het
Neb A G 2: 52,176,792 S5886P probably damaging Het
Nmu A G 5: 76,358,349 probably null Het
Nup153 T C 13: 46,712,926 E214G possibly damaging Het
Olfr301 A C 7: 86,412,551 N104T probably damaging Het
Paqr3 T C 5: 97,095,937 D306G probably benign Het
Plxna2 A G 1: 194,764,570 D796G probably benign Het
Prkra A G 2: 76,630,436 L306S probably damaging Het
Psg20 T A 7: 18,682,713 E159D probably damaging Het
Ptchd3 G T 11: 121,830,420 V40L probably benign Het
Rfx5 T C 3: 94,957,775 probably benign Het
Rimbp2 A G 5: 128,788,211 probably null Het
Slc22a4 C A 11: 53,986,477 probably null Het
Tars A G 15: 11,391,854 V265A possibly damaging Het
Tatdn2 T A 6: 113,710,031 probably null Het
Tenm4 C T 7: 96,729,385 P399L probably damaging Het
Tmem135 A T 7: 89,151,438 D325E probably damaging Het
Tmprss7 A T 16: 45,663,343 I556N probably benign Het
Tom1l2 C T 11: 60,280,269 G23S probably damaging Het
Ubr2 A G 17: 46,930,509 probably benign Het
Vmn1r197 T C 13: 22,328,071 I54T probably benign Het
Vmn2r116 T C 17: 23,384,929 C43R probably damaging Het
Vps33a A G 5: 123,535,308 L405P probably benign Het
Zfp473 C T 7: 44,739,563 D45N probably damaging Het
Other mutations in Olfr792
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01285:Olfr792 APN 10 129540842 missense probably benign 0.07
IGL02090:Olfr792 APN 10 129541307 missense probably damaging 1.00
IGL03338:Olfr792 APN 10 129541056 missense probably damaging 0.99
R0382:Olfr792 UTSW 10 129541014 missense probably benign 0.01
R1672:Olfr792 UTSW 10 129540692 missense probably benign 0.00
R2285:Olfr792 UTSW 10 129540668 missense probably benign 0.22
R2938:Olfr792 UTSW 10 129540615 missense probably damaging 1.00
R3498:Olfr792 UTSW 10 129540909 missense probably damaging 1.00
R5309:Olfr792 UTSW 10 129541265 missense probably benign 0.01
R5312:Olfr792 UTSW 10 129541265 missense probably benign 0.01
R6004:Olfr792 UTSW 10 129540890 missense probably benign 0.31
R6800:Olfr792 UTSW 10 129541263 missense probably damaging 1.00
R7127:Olfr792 UTSW 10 129541067 missense probably damaging 1.00
R7167:Olfr792 UTSW 10 129540738 missense possibly damaging 0.88
R7763:Olfr792 UTSW 10 129541455 missense probably benign
R7819:Olfr792 UTSW 10 129540693 missense probably benign 0.01
Posted On2013-11-18