Incidental Mutation 'IGL01459:Or6c66b'
ID 87932
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or6c66b
Ensembl Gene ENSMUSG00000094496
Gene Name olfactory receptor family 6 subfamily C member 66B
Synonyms Olfr792, MOR108-2, GA_x6K02T2PULF-11219415-11220350
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # IGL01459
Quality Score
Status
Chromosome 10
Chromosomal Location 129376408-129377343 bp(+) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) G to A at 129376410 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 1 (M1I)
Ref Sequence ENSEMBL: ENSMUSP00000149872 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076575] [ENSMUST00000215436]
AlphaFold Q7TRH9
Predicted Effect probably null
Transcript: ENSMUST00000076575
AA Change: M1I

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000096707
Gene: ENSMUSG00000094496
AA Change: M1I

DomainStartEndE-ValueType
Pfam:7tm_4 28 306 1.9e-53 PFAM
Pfam:7tm_1 39 288 4.7e-25 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000215436
AA Change: M1I

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp2a2 A G 5: 122,607,715 (GRCm39) S265P probably benign Het
Brwd1 A G 16: 95,848,620 (GRCm39) F520L probably damaging Het
Cdh5 A T 8: 104,864,449 (GRCm39) D470V probably damaging Het
Cdr2l A G 11: 115,281,378 (GRCm39) R41G probably damaging Het
Csrnp1 C T 9: 119,802,024 (GRCm39) C345Y probably damaging Het
Dscaml1 T A 9: 45,653,981 (GRCm39) Y1419* probably null Het
Entpd3 T C 9: 120,391,007 (GRCm39) S420P probably damaging Het
Epb41 A G 4: 131,691,439 (GRCm39) probably benign Het
Erg A G 16: 95,162,141 (GRCm39) S322P probably damaging Het
Fndc3b T A 3: 27,515,889 (GRCm39) H639L probably benign Het
Grwd1 C T 7: 45,479,834 (GRCm39) probably null Het
Kbtbd8 A G 6: 95,099,789 (GRCm39) N356D probably benign Het
Kif15 A G 9: 122,804,820 (GRCm39) E189G probably damaging Het
Kif2b T C 11: 91,467,849 (GRCm39) K145E possibly damaging Het
Kif5c A G 2: 49,625,569 (GRCm39) D613G probably benign Het
Lipe T G 7: 25,082,967 (GRCm39) Q457P probably damaging Het
Lrp1b A T 2: 40,750,726 (GRCm39) I2946N probably damaging Het
Mtf2 C T 5: 108,228,809 (GRCm39) P42S probably damaging Het
Neb A G 2: 52,066,804 (GRCm39) S5886P probably damaging Het
Nmu A G 5: 76,506,196 (GRCm39) probably null Het
Nup153 T C 13: 46,866,402 (GRCm39) E214G possibly damaging Het
Or14c44 A C 7: 86,061,759 (GRCm39) N104T probably damaging Het
Paqr3 T C 5: 97,243,796 (GRCm39) D306G probably benign Het
Plxna2 A G 1: 194,446,878 (GRCm39) D796G probably benign Het
Prkra A G 2: 76,460,780 (GRCm39) L306S probably damaging Het
Psg20 T A 7: 18,416,638 (GRCm39) E159D probably damaging Het
Ptchd3 G T 11: 121,721,246 (GRCm39) V40L probably benign Het
Rfx5 T C 3: 94,865,086 (GRCm39) probably benign Het
Rimbp2 A G 5: 128,865,275 (GRCm39) probably null Het
Slc22a4 C A 11: 53,877,303 (GRCm39) probably null Het
Tars1 A G 15: 11,391,940 (GRCm39) V265A possibly damaging Het
Tatdn2 T A 6: 113,686,992 (GRCm39) probably null Het
Tenm4 C T 7: 96,378,592 (GRCm39) P399L probably damaging Het
Tmem135 A T 7: 88,800,646 (GRCm39) D325E probably damaging Het
Tmprss7 A T 16: 45,483,706 (GRCm39) I556N probably benign Het
Tom1l2 C T 11: 60,171,095 (GRCm39) G23S probably damaging Het
Ubr2 A G 17: 47,241,435 (GRCm39) probably benign Het
Vmn1r197 T C 13: 22,512,241 (GRCm39) I54T probably benign Het
Vmn2r116 T C 17: 23,603,903 (GRCm39) C43R probably damaging Het
Vps33a A G 5: 123,673,371 (GRCm39) L405P probably benign Het
Zfp473 C T 7: 44,388,987 (GRCm39) D45N probably damaging Het
Other mutations in Or6c66b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01285:Or6c66b APN 10 129,376,711 (GRCm39) missense probably benign 0.07
IGL02090:Or6c66b APN 10 129,377,176 (GRCm39) missense probably damaging 1.00
IGL03338:Or6c66b APN 10 129,376,925 (GRCm39) missense probably damaging 0.99
R0382:Or6c66b UTSW 10 129,376,883 (GRCm39) missense probably benign 0.01
R1672:Or6c66b UTSW 10 129,376,561 (GRCm39) missense probably benign 0.00
R2285:Or6c66b UTSW 10 129,376,537 (GRCm39) missense probably benign 0.22
R2938:Or6c66b UTSW 10 129,376,484 (GRCm39) missense probably damaging 1.00
R3498:Or6c66b UTSW 10 129,376,778 (GRCm39) missense probably damaging 1.00
R5309:Or6c66b UTSW 10 129,377,134 (GRCm39) missense probably benign 0.01
R5312:Or6c66b UTSW 10 129,377,134 (GRCm39) missense probably benign 0.01
R6004:Or6c66b UTSW 10 129,376,759 (GRCm39) missense probably benign 0.31
R6800:Or6c66b UTSW 10 129,377,132 (GRCm39) missense probably damaging 1.00
R7127:Or6c66b UTSW 10 129,376,936 (GRCm39) missense probably damaging 1.00
R7167:Or6c66b UTSW 10 129,376,607 (GRCm39) missense possibly damaging 0.88
R7763:Or6c66b UTSW 10 129,377,324 (GRCm39) missense probably benign
R7819:Or6c66b UTSW 10 129,376,562 (GRCm39) missense probably benign 0.01
R8104:Or6c66b UTSW 10 129,376,826 (GRCm39) missense probably benign
R8189:Or6c66b UTSW 10 129,377,122 (GRCm39) missense probably damaging 0.99
R8672:Or6c66b UTSW 10 129,376,596 (GRCm39) missense probably damaging 0.99
Z1189:Or6c66b UTSW 10 129,377,246 (GRCm39) missense probably benign 0.44
Posted On 2013-11-18