Incidental Mutation 'IGL01459:Kif2b'
ID87937
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Kif2b
Ensembl Gene ENSMUSG00000046755
Gene Namekinesin family member 2B
Synonyms1700063D03Rik
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.700) question?
Stock #IGL01459
Quality Score
Status
Chromosome11
Chromosomal Location91575315-91577558 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 91577023 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Glutamic Acid at position 145 (K145E)
Ref Sequence ENSEMBL: ENSMUSP00000058084 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061019]
Predicted Effect possibly damaging
Transcript: ENSMUST00000061019
AA Change: K145E

PolyPhen 2 Score 0.654 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000058084
Gene: ENSMUSG00000046755
AA Change: K145E

DomainStartEndE-ValueType
low complexity region 55 70 N/A INTRINSIC
low complexity region 90 103 N/A INTRINSIC
low complexity region 151 176 N/A INTRINSIC
KISc 211 549 2.34e-134 SMART
low complexity region 588 603 N/A INTRINSIC
coiled coil region 640 664 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp2a2 A G 5: 122,469,652 S265P probably benign Het
Brwd1 A G 16: 96,047,420 F520L probably damaging Het
Cdh5 A T 8: 104,137,817 D470V probably damaging Het
Cdr2l A G 11: 115,390,552 R41G probably damaging Het
Csrnp1 C T 9: 119,972,958 C345Y probably damaging Het
Dscaml1 T A 9: 45,742,683 Y1419* probably null Het
Entpd3 T C 9: 120,561,941 S420P probably damaging Het
Epb41 A G 4: 131,964,128 probably benign Het
Erg A G 16: 95,361,282 S322P probably damaging Het
Fndc3b T A 3: 27,461,740 H639L probably benign Het
Grwd1 C T 7: 45,830,410 probably null Het
Kbtbd8 A G 6: 95,122,808 N356D probably benign Het
Kif15 A G 9: 122,975,755 E189G probably damaging Het
Kif5c A G 2: 49,735,557 D613G probably benign Het
Lipe T G 7: 25,383,542 Q457P probably damaging Het
Lrp1b A T 2: 40,860,714 I2946N probably damaging Het
Mtf2 C T 5: 108,080,943 P42S probably damaging Het
Neb A G 2: 52,176,792 S5886P probably damaging Het
Nmu A G 5: 76,358,349 probably null Het
Nup153 T C 13: 46,712,926 E214G possibly damaging Het
Olfr301 A C 7: 86,412,551 N104T probably damaging Het
Olfr792 G A 10: 129,540,541 M1I probably null Het
Paqr3 T C 5: 97,095,937 D306G probably benign Het
Plxna2 A G 1: 194,764,570 D796G probably benign Het
Prkra A G 2: 76,630,436 L306S probably damaging Het
Psg20 T A 7: 18,682,713 E159D probably damaging Het
Ptchd3 G T 11: 121,830,420 V40L probably benign Het
Rfx5 T C 3: 94,957,775 probably benign Het
Rimbp2 A G 5: 128,788,211 probably null Het
Slc22a4 C A 11: 53,986,477 probably null Het
Tars A G 15: 11,391,854 V265A possibly damaging Het
Tatdn2 T A 6: 113,710,031 probably null Het
Tenm4 C T 7: 96,729,385 P399L probably damaging Het
Tmem135 A T 7: 89,151,438 D325E probably damaging Het
Tmprss7 A T 16: 45,663,343 I556N probably benign Het
Tom1l2 C T 11: 60,280,269 G23S probably damaging Het
Ubr2 A G 17: 46,930,509 probably benign Het
Vmn1r197 T C 13: 22,328,071 I54T probably benign Het
Vmn2r116 T C 17: 23,384,929 C43R probably damaging Het
Vps33a A G 5: 123,535,308 L405P probably benign Het
Zfp473 C T 7: 44,739,563 D45N probably damaging Het
Other mutations in Kif2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00834:Kif2b APN 11 91576380 missense probably damaging 1.00
IGL01468:Kif2b APN 11 91576365 missense probably damaging 1.00
IGL02897:Kif2b APN 11 91576219 missense probably damaging 1.00
R0076:Kif2b UTSW 11 91575909 missense probably damaging 1.00
R0488:Kif2b UTSW 11 91576972 missense probably benign 0.00
R0524:Kif2b UTSW 11 91575724 missense probably benign 0.00
R0549:Kif2b UTSW 11 91576584 missense probably damaging 1.00
R0893:Kif2b UTSW 11 91575594 missense probably benign 0.16
R1677:Kif2b UTSW 11 91575972 missense probably damaging 1.00
R2025:Kif2b UTSW 11 91577346 missense probably damaging 0.99
R2185:Kif2b UTSW 11 91576971 frame shift probably null
R2290:Kif2b UTSW 11 91575696 missense probably benign 0.00
R4697:Kif2b UTSW 11 91576846 missense probably benign 0.01
R4785:Kif2b UTSW 11 91576428 missense probably benign 0.07
R5429:Kif2b UTSW 11 91577229 missense probably benign 0.03
R5555:Kif2b UTSW 11 91575460 missense probably benign 0.00
R5652:Kif2b UTSW 11 91575830 missense possibly damaging 0.86
R5765:Kif2b UTSW 11 91577242 missense probably benign 0.28
R6101:Kif2b UTSW 11 91575988 missense probably benign 0.00
R6105:Kif2b UTSW 11 91575988 missense probably benign 0.00
R6450:Kif2b UTSW 11 91576366 missense probably damaging 0.99
R6862:Kif2b UTSW 11 91575915 missense probably damaging 1.00
R7097:Kif2b UTSW 11 91576824 missense probably benign 0.00
R7189:Kif2b UTSW 11 91577137 missense probably benign 0.01
R7507:Kif2b UTSW 11 91577443 missense probably benign
R7742:Kif2b UTSW 11 91576585 missense possibly damaging 0.85
R7818:Kif2b UTSW 11 91576126 missense probably damaging 1.00
R7820:Kif2b UTSW 11 91577274 missense probably benign 0.01
R7946:Kif2b UTSW 11 91575745 missense probably benign 0.00
R8378:Kif2b UTSW 11 91576375 missense possibly damaging 0.95
R8442:Kif2b UTSW 11 91576314 missense possibly damaging 0.54
Z1176:Kif2b UTSW 11 91576264 nonsense probably null
Posted On2013-11-18