Incidental Mutation 'IGL01461:Or7e165'
ID |
87974 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Or7e165
|
Ensembl Gene |
ENSMUSG00000058659 |
Gene Name |
olfactory receptor family 7 subfamily E member 165 |
Synonyms |
Olfr58, MOR146-7P, IG6, GA_x6K02T2PVTD-13523015-13523944, MOR146-3 |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.059)
|
Stock # |
IGL01461
|
Quality Score |
|
Status
|
|
Chromosome |
9 |
Chromosomal Location |
19691579-19695360 bp(+) (GRCm39) |
Type of Mutation |
splice site (557 bp from exon) |
DNA Base Change (assembly) |
T to A
at 19695245 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000148538
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000079660]
[ENSMUST00000212363]
[ENSMUST00000215112]
|
AlphaFold |
Q7TRF6 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000079660
AA Change: M272K
PolyPhen 2
Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
|
SMART Domains |
Protein: ENSMUSP00000078603 Gene: ENSMUSG00000063842 AA Change: M272K
Domain | Start | End | E-Value | Type |
Pfam:7tm_4
|
31 |
308 |
1.3e-51 |
PFAM |
Pfam:7TM_GPCR_Srsx
|
35 |
303 |
8.3e-8 |
PFAM |
Pfam:7tm_1
|
41 |
290 |
4.5e-22 |
PFAM |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000212363
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000215112
AA Change: M272K
PolyPhen 2
Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 28 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
2210408I21Rik |
T |
C |
13: 77,429,214 (GRCm39) |
F767S |
probably benign |
Het |
Abca13 |
A |
G |
11: 9,353,834 (GRCm39) |
T3719A |
probably damaging |
Het |
Apob |
A |
T |
12: 8,051,884 (GRCm39) |
M1137L |
probably benign |
Het |
Brd9 |
C |
T |
13: 74,099,717 (GRCm39) |
Q445* |
probably null |
Het |
Cdh23 |
T |
C |
10: 60,244,926 (GRCm39) |
T990A |
possibly damaging |
Het |
Cenpf |
A |
G |
1: 189,389,293 (GRCm39) |
L1513S |
probably damaging |
Het |
Col27a1 |
A |
G |
4: 63,142,480 (GRCm39) |
K56R |
probably damaging |
Het |
Cryaa |
A |
G |
17: 31,900,000 (GRCm39) |
Y118C |
probably damaging |
Het |
Dtl |
T |
C |
1: 191,278,729 (GRCm39) |
T378A |
possibly damaging |
Het |
E330020D12Rik |
A |
G |
1: 153,284,105 (GRCm39) |
|
noncoding transcript |
Het |
F7 |
A |
G |
8: 13,082,245 (GRCm39) |
D145G |
possibly damaging |
Het |
Flvcr2 |
A |
G |
12: 85,849,905 (GRCm39) |
|
probably benign |
Het |
Hltf |
A |
T |
3: 20,154,103 (GRCm39) |
K680* |
probably null |
Het |
Ing1 |
T |
G |
8: 11,611,453 (GRCm39) |
F22V |
probably benign |
Het |
Ipo5 |
A |
G |
14: 121,165,945 (GRCm39) |
D330G |
probably damaging |
Het |
Itgax |
G |
T |
7: 127,734,190 (GRCm39) |
D321Y |
probably damaging |
Het |
Kel |
A |
C |
6: 41,678,845 (GRCm39) |
|
probably null |
Het |
Marchf10 |
T |
C |
11: 105,280,431 (GRCm39) |
K618R |
probably damaging |
Het |
Mast4 |
T |
A |
13: 102,890,576 (GRCm39) |
M925L |
probably damaging |
Het |
Miga1 |
C |
T |
3: 152,040,934 (GRCm39) |
E78K |
probably damaging |
Het |
Or4c106 |
G |
T |
2: 88,682,669 (GRCm39) |
C125F |
probably damaging |
Het |
Pkdrej |
T |
C |
15: 85,704,575 (GRCm39) |
I454V |
possibly damaging |
Het |
Poglut2 |
T |
C |
1: 44,150,094 (GRCm39) |
Q365R |
probably damaging |
Het |
Prpf6 |
C |
A |
2: 181,273,304 (GRCm39) |
T283N |
probably benign |
Het |
R3hdm1 |
A |
G |
1: 128,106,643 (GRCm39) |
H197R |
probably damaging |
Het |
Resf1 |
T |
C |
6: 149,233,013 (GRCm39) |
|
probably benign |
Het |
Smpd4 |
A |
C |
16: 17,439,370 (GRCm39) |
Q7P |
probably damaging |
Het |
Vmn2r84 |
A |
T |
10: 130,227,094 (GRCm39) |
I248K |
possibly damaging |
Het |
|
Other mutations in Or7e165 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01815:Or7e165
|
APN |
9 |
19,695,311 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02408:Or7e165
|
APN |
9 |
19,694,711 (GRCm39) |
missense |
probably benign |
0.31 |
IGL02644:Or7e165
|
APN |
9 |
19,695,010 (GRCm39) |
missense |
probably benign |
0.30 |
IGL03243:Or7e165
|
APN |
9 |
19,694,564 (GRCm39) |
missense |
probably damaging |
0.99 |
R0603:Or7e165
|
UTSW |
9 |
19,695,235 (GRCm39) |
missense |
probably damaging |
1.00 |
R2363:Or7e165
|
UTSW |
9 |
19,694,892 (GRCm39) |
missense |
probably benign |
0.00 |
R2570:Or7e165
|
UTSW |
9 |
19,695,305 (GRCm39) |
missense |
probably damaging |
1.00 |
R3890:Or7e165
|
UTSW |
9 |
19,695,011 (GRCm39) |
missense |
probably benign |
0.03 |
R3892:Or7e165
|
UTSW |
9 |
19,695,011 (GRCm39) |
missense |
probably benign |
0.03 |
R4163:Or7e165
|
UTSW |
9 |
19,695,086 (GRCm39) |
missense |
possibly damaging |
0.69 |
R4610:Or7e165
|
UTSW |
9 |
19,694,442 (GRCm39) |
nonsense |
probably null |
|
R4691:Or7e165
|
UTSW |
9 |
19,694,678 (GRCm39) |
missense |
probably benign |
0.33 |
R4707:Or7e165
|
UTSW |
9 |
19,694,596 (GRCm39) |
missense |
probably damaging |
1.00 |
R4825:Or7e165
|
UTSW |
9 |
19,694,872 (GRCm39) |
missense |
possibly damaging |
0.74 |
R4950:Or7e165
|
UTSW |
9 |
19,695,027 (GRCm39) |
missense |
probably benign |
|
R5185:Or7e165
|
UTSW |
9 |
19,694,672 (GRCm39) |
missense |
probably damaging |
1.00 |
R5202:Or7e165
|
UTSW |
9 |
19,694,514 (GRCm39) |
missense |
possibly damaging |
0.46 |
R5439:Or7e165
|
UTSW |
9 |
19,695,161 (GRCm39) |
missense |
probably damaging |
1.00 |
R5669:Or7e165
|
UTSW |
9 |
19,695,053 (GRCm39) |
missense |
probably benign |
0.02 |
R5672:Or7e165
|
UTSW |
9 |
19,694,507 (GRCm39) |
missense |
possibly damaging |
0.92 |
R6038:Or7e165
|
UTSW |
9 |
19,694,858 (GRCm39) |
missense |
probably benign |
|
R6038:Or7e165
|
UTSW |
9 |
19,694,858 (GRCm39) |
missense |
probably benign |
|
R6212:Or7e165
|
UTSW |
9 |
19,694,585 (GRCm39) |
missense |
probably damaging |
1.00 |
R6415:Or7e165
|
UTSW |
9 |
19,695,044 (GRCm39) |
missense |
probably damaging |
1.00 |
R7385:Or7e165
|
UTSW |
9 |
19,694,507 (GRCm39) |
missense |
possibly damaging |
0.92 |
R7669:Or7e165
|
UTSW |
9 |
19,694,839 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
Posted On |
2013-11-18 |