Incidental Mutation 'IGL01462:Olfr376'
ID88006
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr376
Ensembl Gene ENSMUSG00000063881
Gene Nameolfactory receptor 376
SynonymsGA_x6K02T2P1NL-3535075-3536028, MOR135-12
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01462
Quality Score
Status
Chromosome11
Chromosomal Location73371246-73377836 bp(+) (GRCm38)
Type of Mutationstart codon destroyed
DNA Base Change (assembly) T to C at 73374752 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Threonine at position 1 (M1T)
Ref Sequence ENSEMBL: ENSMUSP00000126073 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078952] [ENSMUST00000120401] [ENSMUST00000127789] [ENSMUST00000170592]
Predicted Effect probably benign
Transcript: ENSMUST00000078952
AA Change: M4T

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000077977
Gene: ENSMUSG00000063881
AA Change: M4T

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 3e-59 PFAM
Pfam:7TM_GPCR_Srsx 41 311 7.4e-8 PFAM
Pfam:7tm_1 47 296 2.7e-27 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000120401
AA Change: M1T

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000113236
Gene: ENSMUSG00000063881
AA Change: M1T

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 38 308 1.1e-7 PFAM
Pfam:7tm_1 44 293 7.2e-36 PFAM
Pfam:7tm_4 142 286 1.4e-46 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000127789
AA Change: M1T
SMART Domains Protein: ENSMUSP00000116228
Gene: ENSMUSG00000072709
AA Change: M1T

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 38 231 7.3e-8 PFAM
Pfam:7tm_1 44 240 2.5e-33 PFAM
Pfam:7tm_4 142 249 4.5e-35 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000170592
AA Change: M1T

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000126073
Gene: ENSMUSG00000063881
AA Change: M1T

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 38 308 1.1e-7 PFAM
Pfam:7tm_1 44 293 7.2e-36 PFAM
Pfam:7tm_4 142 286 1.4e-46 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts9 C A 6: 92,894,266 A30S probably benign Het
Aspg A G 12: 112,122,953 T392A probably benign Het
Atp8b5 C A 4: 43,368,010 Q878K possibly damaging Het
Ccdc85a G T 11: 28,576,506 H339Q probably damaging Het
Clca1 C T 3: 145,007,778 M697I probably benign Het
Cog4 C T 8: 110,866,085 T430M probably benign Het
Col6a5 A G 9: 105,946,075 Y28H unknown Het
Cth A T 3: 157,905,167 Y343N probably damaging Het
Dctn3 A T 4: 41,719,854 L84* probably null Het
Epha5 A T 5: 84,071,233 I868N probably damaging Het
Ephb2 T C 4: 136,771,370 N133D possibly damaging Het
Epor G A 9: 21,959,456 P376L probably damaging Het
Gsdme A G 6: 50,227,374 V201A possibly damaging Het
Hdgf G A 3: 87,914,524 E149K possibly damaging Het
Lrrfip2 T C 9: 111,205,849 probably null Het
Ly6g6d T C 17: 35,074,250 I40V probably benign Het
Mlh3 G A 12: 85,266,736 T892I probably benign Het
Mmp19 C T 10: 128,798,142 T304I probably damaging Het
Mmp28 T C 11: 83,443,776 D384G possibly damaging Het
Moxd1 T C 10: 24,244,388 probably null Het
Ncapg T C 5: 45,671,135 V76A probably benign Het
Nos1 C T 5: 117,867,709 R165C probably benign Het
Olfr47 A G 6: 43,235,625 T6A possibly damaging Het
Pik3c2a T A 7: 116,376,250 H694L possibly damaging Het
Psme2 A G 14: 55,589,671 L60P probably damaging Het
Ptpn23 A G 9: 110,408,107 V4A probably benign Het
Rgr G T 14: 37,044,609 T160K probably damaging Het
Serpind1 A G 16: 17,336,923 I205V probably benign Het
Skap2 T C 6: 51,921,300 Y150C probably damaging Het
Soga3 T G 10: 29,148,258 L390R probably damaging Het
Srsf9 T C 5: 115,332,128 S122P probably damaging Het
Stox1 T G 10: 62,664,682 I700L probably benign Het
Tada1 A G 1: 166,388,725 D165G probably damaging Het
Traf5 A G 1: 191,999,867 S338P probably benign Het
Trim39 G A 17: 36,263,725 probably benign Het
Wbp2 G A 11: 116,081,240 A130V possibly damaging Het
Zcchc17 T C 4: 130,337,109 K96E probably benign Het
Zfp800 G A 6: 28,242,984 L661F possibly damaging Het
Other mutations in Olfr376
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01011:Olfr376 APN 11 73375007 missense probably benign 0.03
IGL01725:Olfr376 APN 11 73375156 missense probably benign 0.39
IGL02225:Olfr376 APN 11 73375078 missense probably damaging 0.98
R0006:Olfr376 UTSW 11 73375588 missense possibly damaging 0.65
R0090:Olfr376 UTSW 11 73375576 missense probably benign 0.04
R0743:Olfr376 UTSW 11 73374889 missense probably benign 0.03
R0884:Olfr376 UTSW 11 73374889 missense probably benign 0.03
R1102:Olfr376 UTSW 11 73374874 missense probably benign 0.00
R1582:Olfr376 UTSW 11 73375264 missense probably damaging 1.00
R1765:Olfr376 UTSW 11 73375344 missense probably damaging 1.00
R1929:Olfr376 UTSW 11 73375601 missense probably damaging 1.00
R1941:Olfr376 UTSW 11 73375621 missense probably damaging 1.00
R4738:Olfr376 UTSW 11 73375350 missense possibly damaging 0.94
R4947:Olfr376 UTSW 11 73375417 nonsense probably null
R5837:Olfr376 UTSW 11 73375648 missense probably benign 0.02
R6440:Olfr376 UTSW 11 73375347 missense probably benign 0.06
R6736:Olfr376 UTSW 11 73375576 missense probably benign 0.18
R7254:Olfr376 UTSW 11 73375375 missense probably benign
R7354:Olfr376 UTSW 11 73375375 missense probably benign 0.01
R7437:Olfr376 UTSW 11 73375018 missense probably benign 0.02
Posted On2013-11-18