Incidental Mutation 'IGL01462:Trim39'
ID88035
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trim39
Ensembl Gene ENSMUSG00000045409
Gene Nametripartite motif-containing 39
SynonymsRnf23, RING-B box-coiled-coil-B30.2, RBCC-B30.2, tfp, 1100001D15Rik, E130103K13Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01462
Quality Score
Status
Chromosome17
Chromosomal Location36258873-36272247 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) G to A at 36263725 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000133529 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042717] [ENSMUST00000113706] [ENSMUST00000173369] [ENSMUST00000173665]
Predicted Effect probably benign
Transcript: ENSMUST00000042717
SMART Domains Protein: ENSMUSP00000039790
Gene: ENSMUSG00000045409

DomainStartEndE-ValueType
low complexity region 4 21 N/A INTRINSIC
RING 29 69 1.9e-10 SMART
BBOX 102 143 3.21e-8 SMART
coiled coil region 184 240 N/A INTRINSIC
PRY 306 359 2.3e-27 SMART
SPRY 360 485 1.95e-31 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000113704
Predicted Effect probably benign
Transcript: ENSMUST00000113706
SMART Domains Protein: ENSMUSP00000109336
Gene: ENSMUSG00000045409

DomainStartEndE-ValueType
low complexity region 4 21 N/A INTRINSIC
RING 29 69 1.9e-10 SMART
BBOX 102 143 3.21e-8 SMART
coiled coil region 184 240 N/A INTRINSIC
PRY 306 359 2.3e-27 SMART
SPRY 360 485 1.95e-31 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000172832
Predicted Effect probably benign
Transcript: ENSMUST00000173369
SMART Domains Protein: ENSMUSP00000133298
Gene: ENSMUSG00000045409

DomainStartEndE-ValueType
low complexity region 4 21 N/A INTRINSIC
RING 29 69 1.9e-10 SMART
BBOX 102 143 3.21e-8 SMART
coiled coil region 184 240 N/A INTRINSIC
PRY 314 367 1.23e-27 SMART
SPRY 368 493 1.95e-31 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000173665
SMART Domains Protein: ENSMUSP00000133529
Gene: ENSMUSG00000045409

DomainStartEndE-ValueType
BBOX 1 40 5.81e-6 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174197
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. This gene lies within the major histocompatibility complex class I region on chromosome 6. Alternate splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts9 C A 6: 92,894,266 A30S probably benign Het
Aspg A G 12: 112,122,953 T392A probably benign Het
Atp8b5 C A 4: 43,368,010 Q878K possibly damaging Het
Ccdc85a G T 11: 28,576,506 H339Q probably damaging Het
Clca1 C T 3: 145,007,778 M697I probably benign Het
Cog4 C T 8: 110,866,085 T430M probably benign Het
Col6a5 A G 9: 105,946,075 Y28H unknown Het
Cth A T 3: 157,905,167 Y343N probably damaging Het
Dctn3 A T 4: 41,719,854 L84* probably null Het
Epha5 A T 5: 84,071,233 I868N probably damaging Het
Ephb2 T C 4: 136,771,370 N133D possibly damaging Het
Epor G A 9: 21,959,456 P376L probably damaging Het
Gsdme A G 6: 50,227,374 V201A possibly damaging Het
Hdgf G A 3: 87,914,524 E149K possibly damaging Het
Lrrfip2 T C 9: 111,205,849 probably null Het
Ly6g6d T C 17: 35,074,250 I40V probably benign Het
Mlh3 G A 12: 85,266,736 T892I probably benign Het
Mmp19 C T 10: 128,798,142 T304I probably damaging Het
Mmp28 T C 11: 83,443,776 D384G possibly damaging Het
Moxd1 T C 10: 24,244,388 probably null Het
Ncapg T C 5: 45,671,135 V76A probably benign Het
Nos1 C T 5: 117,867,709 R165C probably benign Het
Olfr376 T C 11: 73,374,752 M1T probably null Het
Olfr47 A G 6: 43,235,625 T6A possibly damaging Het
Pik3c2a T A 7: 116,376,250 H694L possibly damaging Het
Psme2 A G 14: 55,589,671 L60P probably damaging Het
Ptpn23 A G 9: 110,408,107 V4A probably benign Het
Rgr G T 14: 37,044,609 T160K probably damaging Het
Serpind1 A G 16: 17,336,923 I205V probably benign Het
Skap2 T C 6: 51,921,300 Y150C probably damaging Het
Soga3 T G 10: 29,148,258 L390R probably damaging Het
Srsf9 T C 5: 115,332,128 S122P probably damaging Het
Stox1 T G 10: 62,664,682 I700L probably benign Het
Tada1 A G 1: 166,388,725 D165G probably damaging Het
Traf5 A G 1: 191,999,867 S338P probably benign Het
Wbp2 G A 11: 116,081,240 A130V possibly damaging Het
Zcchc17 T C 4: 130,337,109 K96E probably benign Het
Zfp800 G A 6: 28,242,984 L661F possibly damaging Het
Other mutations in Trim39
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01458:Trim39 APN 17 36263963 splice site probably benign
IGL02243:Trim39 APN 17 36260384 missense probably damaging 1.00
IGL03390:Trim39 APN 17 36260571 missense probably damaging 0.99
PIT4305001:Trim39 UTSW 17 36268970 missense possibly damaging 0.93
R0458:Trim39 UTSW 17 36261512 missense probably damaging 1.00
R0569:Trim39 UTSW 17 36263731 missense probably benign 0.36
R1565:Trim39 UTSW 17 36268854 missense probably damaging 1.00
R1769:Trim39 UTSW 17 36263940 missense probably damaging 1.00
R1969:Trim39 UTSW 17 36268753 missense probably benign 0.01
R2009:Trim39 UTSW 17 36263754 missense possibly damaging 0.92
R2568:Trim39 UTSW 17 36269164 unclassified probably benign
R5206:Trim39 UTSW 17 36260490 missense probably damaging 1.00
R5443:Trim39 UTSW 17 36260753 missense probably damaging 1.00
R6481:Trim39 UTSW 17 36268662 missense probably benign 0.03
R7132:Trim39 UTSW 17 36260655 missense probably benign 0.25
R7563:Trim39 UTSW 17 36260915 missense probably damaging 1.00
R7739:Trim39 UTSW 17 36260504 missense possibly damaging 0.50
Posted On2013-11-18