Incidental Mutation 'IGL01463:Vmn2r93'
ID 88039
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r93
Ensembl Gene ENSMUSG00000079698
Gene Name vomeronasal 2, receptor 93
Synonyms EG627132
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # IGL01463
Quality Score
Status
Chromosome 17
Chromosomal Location 18518543-18546703 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 18525150 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 269 (N269K)
Ref Sequence ENSEMBL: ENSMUSP00000156230 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079206] [ENSMUST00000231879] [ENSMUST00000231938]
AlphaFold L7N1Z9
Predicted Effect probably damaging
Transcript: ENSMUST00000079206
AA Change: N269K

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000078200
Gene: ENSMUSG00000079698
AA Change: N269K

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:ANF_receptor 82 453 5.9e-40 PFAM
Pfam:NCD3G 509 562 2.6e-21 PFAM
Pfam:7tm_3 594 830 1.5e-50 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000231879
AA Change: N269K

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000231938
AA Change: N269K

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 13 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam22 T C 5: 8,142,790 (GRCm39) D773G probably damaging Het
Clvs1 A G 4: 9,429,818 (GRCm39) T274A probably benign Het
Cyp2c50 G T 19: 40,079,422 (GRCm39) C172F probably damaging Het
Fam83h G T 15: 75,875,637 (GRCm39) R567S possibly damaging Het
Fastkd1 A G 2: 69,520,405 (GRCm39) probably null Het
Gmds A T 13: 32,418,341 (GRCm39) Y48N probably damaging Het
Mov10 C T 3: 104,707,640 (GRCm39) R578H probably damaging Het
Pcna A T 2: 132,093,349 (GRCm39) Y133N probably damaging Het
Rhag T C 17: 41,139,646 (GRCm39) I126T probably damaging Het
Sdr16c6 C T 4: 4,063,238 (GRCm39) G179D probably damaging Het
Sv2b C T 7: 74,786,203 (GRCm39) G406S probably damaging Het
Tiparp G T 3: 65,460,030 (GRCm39) G442* probably null Het
Vmn2r4 A T 3: 64,313,816 (GRCm39) N388K probably damaging Het
Other mutations in Vmn2r93
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00743:Vmn2r93 APN 17 18,546,504 (GRCm39) missense probably damaging 1.00
IGL01326:Vmn2r93 APN 17 18,536,906 (GRCm39) missense possibly damaging 0.92
IGL01328:Vmn2r93 APN 17 18,545,819 (GRCm39) missense probably benign 0.00
IGL01360:Vmn2r93 APN 17 18,525,510 (GRCm39) missense possibly damaging 0.71
IGL01382:Vmn2r93 APN 17 18,533,578 (GRCm39) nonsense probably null
IGL02057:Vmn2r93 APN 17 18,546,032 (GRCm39) missense probably damaging 1.00
IGL02257:Vmn2r93 APN 17 18,545,770 (GRCm39) unclassified probably benign
IGL02686:Vmn2r93 APN 17 18,533,526 (GRCm39) missense possibly damaging 0.89
IGL02720:Vmn2r93 APN 17 18,525,296 (GRCm39) missense probably damaging 1.00
IGL03328:Vmn2r93 APN 17 18,525,220 (GRCm39) missense probably damaging 1.00
PIT4576001:Vmn2r93 UTSW 17 18,533,473 (GRCm39) missense probably benign
R0067:Vmn2r93 UTSW 17 18,546,672 (GRCm39) missense probably benign 0.00
R0067:Vmn2r93 UTSW 17 18,546,672 (GRCm39) missense probably benign 0.00
R0240:Vmn2r93 UTSW 17 18,525,061 (GRCm39) missense probably benign 0.00
R0240:Vmn2r93 UTSW 17 18,525,061 (GRCm39) missense probably benign 0.00
R0488:Vmn2r93 UTSW 17 18,546,311 (GRCm39) missense probably damaging 1.00
R0667:Vmn2r93 UTSW 17 18,546,503 (GRCm39) missense probably damaging 1.00
R0668:Vmn2r93 UTSW 17 18,518,667 (GRCm39) missense probably benign 0.00
R0850:Vmn2r93 UTSW 17 18,525,279 (GRCm39) missense possibly damaging 0.93
R0924:Vmn2r93 UTSW 17 18,524,443 (GRCm39) missense probably benign
R0947:Vmn2r93 UTSW 17 18,524,343 (GRCm39) missense probably benign 0.06
R1124:Vmn2r93 UTSW 17 18,518,710 (GRCm39) missense probably benign 0.00
R1584:Vmn2r93 UTSW 17 18,525,413 (GRCm39) missense possibly damaging 0.84
R1943:Vmn2r93 UTSW 17 18,546,063 (GRCm39) missense probably benign 0.04
R2012:Vmn2r93 UTSW 17 18,536,840 (GRCm39) missense probably benign 0.01
R2018:Vmn2r93 UTSW 17 18,546,324 (GRCm39) missense probably damaging 1.00
R2196:Vmn2r93 UTSW 17 18,525,428 (GRCm39) missense probably damaging 1.00
R2373:Vmn2r93 UTSW 17 18,518,665 (GRCm39) missense probably benign
R2864:Vmn2r93 UTSW 17 18,546,323 (GRCm39) missense probably damaging 1.00
R4276:Vmn2r93 UTSW 17 18,525,092 (GRCm39) missense possibly damaging 0.47
R4446:Vmn2r93 UTSW 17 18,524,312 (GRCm39) missense possibly damaging 0.93
R4537:Vmn2r93 UTSW 17 18,525,194 (GRCm39) missense possibly damaging 0.86
R4674:Vmn2r93 UTSW 17 18,525,255 (GRCm39) missense probably benign 0.34
R4726:Vmn2r93 UTSW 17 18,536,960 (GRCm39) missense probably damaging 1.00
R4936:Vmn2r93 UTSW 17 18,524,327 (GRCm39) missense possibly damaging 0.95
R4984:Vmn2r93 UTSW 17 18,533,389 (GRCm39) splice site probably null
R5111:Vmn2r93 UTSW 17 18,546,326 (GRCm39) missense probably damaging 0.99
R5749:Vmn2r93 UTSW 17 18,518,546 (GRCm39) missense probably benign 0.06
R5918:Vmn2r93 UTSW 17 18,546,030 (GRCm39) missense probably damaging 1.00
R5921:Vmn2r93 UTSW 17 18,546,030 (GRCm39) missense probably damaging 1.00
R6091:Vmn2r93 UTSW 17 18,545,958 (GRCm39) missense probably benign 0.06
R6283:Vmn2r93 UTSW 17 18,524,366 (GRCm39) missense probably benign 0.02
R6680:Vmn2r93 UTSW 17 18,536,920 (GRCm39) nonsense probably null
R6876:Vmn2r93 UTSW 17 18,525,450 (GRCm39) missense probably benign 0.00
R6963:Vmn2r93 UTSW 17 18,536,849 (GRCm39) missense probably damaging 1.00
R6996:Vmn2r93 UTSW 17 18,524,903 (GRCm39) missense probably damaging 1.00
R7027:Vmn2r93 UTSW 17 18,533,548 (GRCm39) missense probably benign 0.01
R7034:Vmn2r93 UTSW 17 18,546,672 (GRCm39) missense probably benign 0.00
R7036:Vmn2r93 UTSW 17 18,546,672 (GRCm39) missense probably benign 0.00
R7246:Vmn2r93 UTSW 17 18,546,012 (GRCm39) missense possibly damaging 0.89
R7258:Vmn2r93 UTSW 17 18,525,403 (GRCm39) missense probably benign 0.32
R7323:Vmn2r93 UTSW 17 18,533,497 (GRCm39) nonsense probably null
R7325:Vmn2r93 UTSW 17 18,524,249 (GRCm39) missense probably benign 0.01
R7390:Vmn2r93 UTSW 17 18,525,329 (GRCm39) missense probably damaging 1.00
R7427:Vmn2r93 UTSW 17 18,546,672 (GRCm39) missense probably benign 0.00
R7428:Vmn2r93 UTSW 17 18,546,672 (GRCm39) missense probably benign 0.00
R7448:Vmn2r93 UTSW 17 18,546,248 (GRCm39) missense probably benign 0.19
R7453:Vmn2r93 UTSW 17 18,533,580 (GRCm39) missense probably benign 0.10
R7562:Vmn2r93 UTSW 17 18,518,731 (GRCm39) missense probably benign 0.01
R7662:Vmn2r93 UTSW 17 18,525,631 (GRCm39) missense probably benign 0.00
R7682:Vmn2r93 UTSW 17 18,525,583 (GRCm39) missense probably benign 0.03
R7704:Vmn2r93 UTSW 17 18,536,910 (GRCm39) missense probably benign 0.01
R7772:Vmn2r93 UTSW 17 18,533,482 (GRCm39) missense probably damaging 0.99
R7957:Vmn2r93 UTSW 17 18,545,954 (GRCm39) nonsense probably null
R8276:Vmn2r93 UTSW 17 18,525,649 (GRCm39) critical splice donor site probably null
R8290:Vmn2r93 UTSW 17 18,524,291 (GRCm39) missense probably damaging 1.00
R8362:Vmn2r93 UTSW 17 18,546,353 (GRCm39) missense probably benign 0.02
R8376:Vmn2r93 UTSW 17 18,525,230 (GRCm39) missense probably damaging 1.00
R8870:Vmn2r93 UTSW 17 18,525,320 (GRCm39) missense possibly damaging 0.91
R8925:Vmn2r93 UTSW 17 18,546,500 (GRCm39) missense probably damaging 0.99
R8927:Vmn2r93 UTSW 17 18,546,500 (GRCm39) missense probably damaging 0.99
R8954:Vmn2r93 UTSW 17 18,546,252 (GRCm39) missense probably damaging 0.99
R9038:Vmn2r93 UTSW 17 18,524,471 (GRCm39) missense probably benign
R9131:Vmn2r93 UTSW 17 18,546,143 (GRCm39) missense probably damaging 0.99
R9205:Vmn2r93 UTSW 17 18,524,281 (GRCm39) missense probably damaging 1.00
R9530:Vmn2r93 UTSW 17 18,518,562 (GRCm39) missense probably damaging 0.96
Z1088:Vmn2r93 UTSW 17 18,546,665 (GRCm39) missense probably damaging 1.00
Z1177:Vmn2r93 UTSW 17 18,525,600 (GRCm39) missense probably damaging 1.00
Posted On 2013-11-18