Incidental Mutation 'IGL01467:Olfr165'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr165
Ensembl Gene ENSMUSG00000050158
Gene Nameolfactory receptor 165
SynonymsMOR279-1, GA_x54KRFPKG5P-15855164-15854223
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.065) question?
Stock #IGL01467
Quality Score
Chromosomal Location19406244-19423134 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 19407789 bp
Amino Acid Change Threonine to Alanine at position 77 (T77A)
Ref Sequence ENSEMBL: ENSMUSP00000146100 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052516] [ENSMUST00000206110] [ENSMUST00000206410]
Predicted Effect probably benign
Transcript: ENSMUST00000052516
AA Change: T76A

PolyPhen 2 Score 0.238 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000062079
Gene: ENSMUSG00000050158
AA Change: T76A

Pfam:7tm_4 29 309 5.6e-48 PFAM
Pfam:7TM_GPCR_Srsx 36 306 6e-10 PFAM
Pfam:7tm_1 42 291 4e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000103984
Predicted Effect probably benign
Transcript: ENSMUST00000206110
AA Change: T76A

PolyPhen 2 Score 0.238 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000206410
AA Change: T77A

PolyPhen 2 Score 0.238 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam1a A G 5: 121,519,728 C501R probably damaging Het
Atxn1 C T 13: 45,567,193 V409I probably damaging Het
Cdkn2aip T C 8: 47,711,212 R489G probably damaging Het
Cgn A G 3: 94,779,588 S135P probably damaging Het
Cpne3 C A 4: 19,553,737 C98F probably benign Het
Cyp2c23 T C 19: 44,015,073 N221S possibly damaging Het
Dnah8 A G 17: 30,779,916 N3525S probably damaging Het
Efr3b T C 12: 3,969,597 E560G probably damaging Het
Eif2b5 C A 16: 20,508,964 C154* probably null Het
Eps8l2 A G 7: 141,361,601 E595G probably damaging Het
Gm8394 A G 10: 85,314,122 noncoding transcript Het
Gm9839 A T 1: 32,519,951 I350N probably damaging Het
Hdlbp A T 1: 93,417,698 probably benign Het
Il18rap A T 1: 40,548,639 I466F probably damaging Het
Itpr1 T A 6: 108,488,496 I2123N probably damaging Het
Jakmip2 A G 18: 43,582,287 I58T probably benign Het
Kdm2a A G 19: 4,324,407 S899P probably damaging Het
Mmp15 T A 8: 95,366,331 F113I probably benign Het
Neb T C 2: 52,159,487 H6448R possibly damaging Het
Olfr340 C T 2: 36,452,644 R20* probably null Het
Pdgfc A G 3: 81,209,091 T251A probably damaging Het
Pdgfra T C 5: 75,185,631 probably null Het
Pdpk1 A G 17: 24,088,170 S269P probably damaging Het
Pip4k2c A T 10: 127,199,629 F347L probably benign Het
Platr26 T C 2: 71,723,312 noncoding transcript Het
Pnisr C T 4: 21,874,650 probably benign Het
Rab3gap1 T A 1: 127,930,384 probably null Het
Scn10a C T 9: 119,658,412 V619I probably benign Het
Slc38a11 T A 2: 65,316,856 T426S probably benign Het
Son T C 16: 91,657,277 S971P possibly damaging Het
Stk33 T A 7: 109,329,589 I239L probably damaging Het
Tiparp G T 3: 65,552,609 G442* probably null Het
Tmem270 G T 5: 134,901,961 probably benign Het
Vmn2r4 A T 3: 64,406,395 N388K probably damaging Het
Zfp750 A T 11: 121,512,941 C369* probably null Het
Other mutations in Olfr165
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01353:Olfr165 APN 16 19407583 missense probably benign 0.03
IGL01355:Olfr165 APN 16 19407583 missense probably benign 0.03
IGL01363:Olfr165 APN 16 19407583 missense probably benign 0.03
IGL02267:Olfr165 APN 16 19407164 missense possibly damaging 0.80
R1194:Olfr165 UTSW 16 19407180 missense possibly damaging 0.75
R1624:Olfr165 UTSW 16 19407704 missense probably benign 0.06
R2248:Olfr165 UTSW 16 19407194 missense probably damaging 0.98
R4865:Olfr165 UTSW 16 19407301 missense probably damaging 0.98
R4988:Olfr165 UTSW 16 19407110 missense probably benign 0.00
R5384:Olfr165 UTSW 16 19407797 missense probably damaging 1.00
R5858:Olfr165 UTSW 16 19407225 missense possibly damaging 0.91
R5997:Olfr165 UTSW 16 19407944 missense probably benign 0.10
R6301:Olfr165 UTSW 16 19407417 missense possibly damaging 0.96
R6570:Olfr165 UTSW 16 19407318 missense probably benign 0.00
R6703:Olfr165 UTSW 16 19407372 missense probably benign 0.03
R6953:Olfr165 UTSW 16 19407528 missense probably benign 0.04
R7424:Olfr165 UTSW 16 19407194 missense probably damaging 0.98
R7975:Olfr165 UTSW 16 19407551 missense probably damaging 1.00
R8312:Olfr165 UTSW 16 19407237 missense probably benign 0.11
Z1176:Olfr165 UTSW 16 19407735 missense probably benign
Posted On2013-11-18