Incidental Mutation 'IGL01467:Tmem270'
ID88134
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem270
Ensembl Gene ENSMUSG00000040576
Gene Nametransmembrane protein 270
Synonyms1700111I05Rik, Wbscr28
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.050) question?
Stock #IGL01467
Quality Score
Status
Chromosome5
Chromosomal Location134901593-134906733 bp(-) (GRCm38)
Type of Mutationintron
DNA Base Change (assembly) G to T at 134901961 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000144496 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047305] [ENSMUST00000201316]
Predicted Effect unknown
Transcript: ENSMUST00000047305
AA Change: N177K
SMART Domains Protein: ENSMUSP00000045190
Gene: ENSMUSG00000040576
AA Change: N177K

DomainStartEndE-ValueType
Pfam:WBS28 1 181 3.8e-76 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000201316
SMART Domains Protein: ENSMUSP00000144496
Gene: ENSMUSG00000040576

DomainStartEndE-ValueType
Pfam:WBS28 1 264 1.8e-123 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam1a A G 5: 121,519,728 C501R probably damaging Het
Atxn1 C T 13: 45,567,193 V409I probably damaging Het
Cdkn2aip T C 8: 47,711,212 R489G probably damaging Het
Cgn A G 3: 94,779,588 S135P probably damaging Het
Cpne3 C A 4: 19,553,737 C98F probably benign Het
Cyp2c23 T C 19: 44,015,073 N221S possibly damaging Het
Dnah8 A G 17: 30,779,916 N3525S probably damaging Het
Efr3b T C 12: 3,969,597 E560G probably damaging Het
Eif2b5 C A 16: 20,508,964 C154* probably null Het
Eps8l2 A G 7: 141,361,601 E595G probably damaging Het
Gm8394 A G 10: 85,314,122 noncoding transcript Het
Gm9839 A T 1: 32,519,951 I350N probably damaging Het
Hdlbp A T 1: 93,417,698 probably benign Het
Il18rap A T 1: 40,548,639 I466F probably damaging Het
Itpr1 T A 6: 108,488,496 I2123N probably damaging Het
Jakmip2 A G 18: 43,582,287 I58T probably benign Het
Kdm2a A G 19: 4,324,407 S899P probably damaging Het
Mmp15 T A 8: 95,366,331 F113I probably benign Het
Neb T C 2: 52,159,487 H6448R possibly damaging Het
Olfr165 T C 16: 19,407,789 T77A probably benign Het
Olfr340 C T 2: 36,452,644 R20* probably null Het
Pdgfc A G 3: 81,209,091 T251A probably damaging Het
Pdgfra T C 5: 75,185,631 probably null Het
Pdpk1 A G 17: 24,088,170 S269P probably damaging Het
Pip4k2c A T 10: 127,199,629 F347L probably benign Het
Platr26 T C 2: 71,723,312 noncoding transcript Het
Pnisr C T 4: 21,874,650 probably benign Het
Rab3gap1 T A 1: 127,930,384 probably null Het
Scn10a C T 9: 119,658,412 V619I probably benign Het
Slc38a11 T A 2: 65,316,856 T426S probably benign Het
Son T C 16: 91,657,277 S971P possibly damaging Het
Stk33 T A 7: 109,329,589 I239L probably damaging Het
Tiparp G T 3: 65,552,609 G442* probably null Het
Vmn2r4 A T 3: 64,406,395 N388K probably damaging Het
Zfp750 A T 11: 121,512,941 C369* probably null Het
Other mutations in Tmem270
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01402:Tmem270 APN 5 134901909 splice site probably benign
R0126:Tmem270 UTSW 5 134902788 missense probably benign 0.27
R2225:Tmem270 UTSW 5 134906638 missense probably damaging 0.99
R4603:Tmem270 UTSW 5 134901628 nonsense probably null
R5523:Tmem270 UTSW 5 134902782 missense probably benign 0.16
R5859:Tmem270 UTSW 5 134902884 missense probably benign 0.03
R7226:Tmem270 UTSW 5 134901684 missense probably benign 0.43
R7883:Tmem270 UTSW 5 134902827 missense possibly damaging 0.92
R7966:Tmem270 UTSW 5 134902827 missense possibly damaging 0.92
Z1088:Tmem270 UTSW 5 134906656 missense probably damaging 0.99
Posted On2013-11-18