Incidental Mutation 'IGL01468:Prss39'
ID88186
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prss39
Ensembl Gene ENSMUSG00000026125
Gene Nameprotease, serine 39
SynonymsTesp1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.067) question?
Stock #IGL01468
Quality Score
Status
Chromosome1
Chromosomal Location34498410-34503063 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) C to T at 34499400 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000140460 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027299] [ENSMUST00000191604]
Predicted Effect probably benign
Transcript: ENSMUST00000027299
SMART Domains Protein: ENSMUSP00000027299
Gene: ENSMUSG00000026125

DomainStartEndE-ValueType
signal peptide 1 31 N/A INTRINSIC
low complexity region 35 47 N/A INTRINSIC
Tryp_SPc 67 307 7.97e-60 SMART
low complexity region 348 361 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000191604
SMART Domains Protein: ENSMUSP00000140460
Gene: ENSMUSG00000026125

DomainStartEndE-ValueType
signal peptide 1 31 N/A INTRINSIC
low complexity region 35 47 N/A INTRINSIC
Pfam:Trypsin 68 114 1.5e-12 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 G A 10: 80,003,877 V781I probably benign Het
Aldh5a1 G T 13: 24,911,553 probably benign Het
Arhgap12 T C 18: 6,057,576 T435A probably benign Het
Atrnl1 G A 19: 57,699,712 V870I probably benign Het
Cerkl A T 2: 79,343,215 probably null Het
Cntnap2 T A 6: 47,271,371 L13* probably null Het
Cr2 G A 1: 195,168,535 P208S probably damaging Het
Dapk1 A G 13: 60,760,798 D1075G probably benign Het
Dhx57 T A 17: 80,255,610 K863* probably null Het
Dnaaf5 C A 5: 139,151,480 probably null Het
Fbxw7 T A 3: 84,972,499 I336K probably benign Het
Ftcd A G 10: 76,584,587 D385G probably benign Het
Gm10153 T C 7: 142,190,041 S117G unknown Het
Gzmb T C 14: 56,260,315 Y156C probably benign Het
Herc3 T A 6: 58,854,895 D83E probably benign Het
Kif2b A G 11: 91,576,365 V364A probably damaging Het
Mknk2 A G 10: 80,667,664 probably benign Het
Olfr1352 A T 10: 78,983,862 Q24L probably damaging Het
Pgm2 A T 4: 99,962,170 N197I possibly damaging Het
Shroom3 T C 5: 92,940,342 V236A probably damaging Het
Slc17a8 C T 10: 89,592,021 probably null Het
Slc24a3 A G 2: 145,613,580 Y463C probably benign Het
Slc4a7 A G 14: 14,737,480 E149G probably damaging Het
Synj1 G A 16: 91,010,172 probably benign Het
Tas2r138 T A 6: 40,612,476 M279L probably benign Het
Terb1 A G 8: 104,482,167 probably benign Het
Tiparp G T 3: 65,552,609 G442* probably null Het
Trmt5 C T 12: 73,281,104 V442I probably benign Het
Tsc2 T C 17: 24,621,097 I383V possibly damaging Het
Uchl4 A G 9: 64,235,716 T160A possibly damaging Het
Vmn2r3 A T 3: 64,274,961 M439K possibly damaging Het
Vmn2r4 A T 3: 64,406,395 N388K probably damaging Het
Vmn2r52 A T 7: 10,158,941 L757Q probably damaging Het
Zfp518a T C 19: 40,916,031 V1468A probably benign Het
Zxdc A T 6: 90,373,779 E404V probably damaging Het
Other mutations in Prss39
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01432:Prss39 APN 1 34502135 missense probably benign 0.01
IGL01744:Prss39 APN 1 34502199 splice site probably null
IGL02224:Prss39 APN 1 34499378 missense probably damaging 1.00
R0128:Prss39 UTSW 1 34502200 unclassified probably benign
R0130:Prss39 UTSW 1 34502200 unclassified probably benign
R0269:Prss39 UTSW 1 34500198 missense probably damaging 0.96
R0617:Prss39 UTSW 1 34500198 missense probably damaging 0.96
R1078:Prss39 UTSW 1 34502086 missense probably benign 0.00
R1539:Prss39 UTSW 1 34498535 missense possibly damaging 0.85
R1796:Prss39 UTSW 1 34500033 missense possibly damaging 0.70
R4644:Prss39 UTSW 1 34502126 missense probably damaging 0.96
R5417:Prss39 UTSW 1 34500128 missense probably benign
R5496:Prss39 UTSW 1 34500261 missense possibly damaging 0.92
R5511:Prss39 UTSW 1 34502797 missense possibly damaging 0.65
R5977:Prss39 UTSW 1 34502702 missense probably damaging 1.00
R6333:Prss39 UTSW 1 34500069 missense probably benign 0.02
R6833:Prss39 UTSW 1 34498616 missense possibly damaging 0.84
R6834:Prss39 UTSW 1 34498616 missense possibly damaging 0.84
R7230:Prss39 UTSW 1 34502147 missense probably damaging 0.98
R7261:Prss39 UTSW 1 34500288 missense probably damaging 0.99
R7467:Prss39 UTSW 1 34499392 critical splice donor site probably null
R7509:Prss39 UTSW 1 34500199 missense possibly damaging 0.85
R7709:Prss39 UTSW 1 34502628 missense probably damaging 1.00
R7894:Prss39 UTSW 1 34500227 missense probably benign 0.16
R8730:Prss39 UTSW 1 34500117 missense probably damaging 1.00
Posted On2013-11-18